Interesting facts
Interesting Facts about 7-Chloro-3-hydroxy-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one
The compound 7-chloro-3-hydroxy-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one is a fascinating member of the benzodiazepine family, which is well known for its psychoactive properties. This compound stands out for several reasons:
- Psychoactive Potential: Benzodiazepines are primarily recognized for their role as anxiolytics, sedatives, and muscle relaxants. Given the structure of this compound, it may exhibit potential properties in mental health and therapeutic applications.
- Structural Complexity: The presence of both a hydroxyl group and a chloro substituent contributes to its pharmacological profile. The complex structure allows for diverse interactions with biological targets.
- Research Relevance: Compounds like this one are of great interest in medicinal chemistry. They are often studied for their interaction with GABAA receptors, which play a crucial role in inhibitory neurotransmission across the brain.
- Pharmaceutical Applications: There is ongoing research into how derivatives of benzodiazepines can be optimized for better efficacy, fewer side effects, and potential applications in conditions like anxiety, insomnia, and seizures.
- Innovative Synthesis: The synthesis of benzodiazepines often involves intricate multi-step organic reactions, making them a popular subject of study for students and chemists alike.
As one delves into the chemistry of this compound, it's evident that the intersection of structure and function offers invaluable insights into drug development. As Nobel Prize winner Mario Molina once said, “Chemistry knows no borders,” and the exploration of diverse compounds like this one certainly embodies that spirit!
Whether you're a budding chemistry student or an experienced researcher, the realm of benzodiazepines continues to present remarkable opportunities for discovery and innovation.
Synonyms
oxazepam
Serax
604-75-1
Tazepam
Adumbran
Droxacepam
Zaxopam
Ansioxacepam
Durazepam
Noctazepam
Psiquiwas
Quilibrex
Anxiolit
Aplakil
Astress
Drimuel
Limbial
Murelax
Nesontil
Pacienx
Praxiten
Sedigoa
Serenid
Serepax
Seresta
Bonare
Isodin
Propax
Rondar
Serpax
Sobril
Vaben
Azutranquil
Hi-Long
Psicopax
Sigacalm
Uskan
(RS)-Oxazepam
Nortemazepam
Tarchomin
Nozepam
Serenid-D
(+-)-Oxazepam
Oxazepamum
Abboxapam
Alepam
Anxiolit retard
QUEN
Tranquo-buscopan-wirkstoff
WY-3498
Z10-Tr
N-Desmethyltemazepam
Ossazepam
Oxozepam
Tacepam
Ro 5-6789
Z 10 tr
CB 8092
Oxazepam civ
Oxazepamum [INN-Latin]
2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-3-hydroxy-5-phenyl-
Wy 3498
7-Chloro-3-hydroxy-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
CCRIS 488
7-Chloro-1,3-dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one
HSDB 3140
UNII-6GOW6DWN2A
6GOW6DWN2A
EINECS 210-076-9
NSC 169448
NSC-169448
CHEBI:7823
DTXSID1021087
7-chloro-3-hydroxy-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one
J3.308A
1,3-Dihydro-7-chloro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one
DTXCID301087
Lederpam
NIOSH/DF2371850
Oxanid
Oxa-puren
NSC169448
Oxazepam [USAN:USP:INN:BAN:JAN]
Ossazepam [DCIT]
NCGC00159323-02
NCGC00159323-03
Oxazipam
Hilong
OXAZEPAM (IARC)
OXAZEPAM [IARC]
Oxazepamum (INN-Latin)
DF23718500
1,3-Dihydro-7-chloro-3-hydroxy-5-phenyl-3H-1,4-benzodiazepin-2-one
7-Chloro-1,3-dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepine-2-one
OXAZEPAM (MART.)
OXAZEPAM [MART.]
OXAZEPAM CIV (USP-RS)
OXAZEPAM CIV [USP-RS]
OXAZEPAM (EP MONOGRAPH)
OXAZEPAM [EP MONOGRAPH]
OXAZEPAM (USP MONOGRAPH)
OXAZEPAM [USP MONOGRAPH]
Oxazepam (USAN:USP:INN:BAN:JAN)
3H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-3-hydroxy-5-phenyl-
2H-1,4-BENZODIAZEPIN-2-ONE, 7-CHLORO-1,3-DIHYDRO-3-HYDROXY-5-PHENYL-, (+/-)-
CAS-604-75-1
TEMAZEPAM IMPURITY B (EP IMPURITY)
TEMAZEPAM IMPURITY B [EP IMPURITY]
Serax (TN)
Oxazepam (JAN/USP/INN)
DEA No. 2835
OXAZEPAM [HSDB]
OXAZEPAM [USAN]
OXAZEPAM [INN]
OXAZEPAM [JAN]
OXAZEPAM [MI]
OXAZEPAM [VANDF]
(.+/-.)-Oxazepam
CHEMBL568
OXAZEPAM [WHO-DD]
(+-)-7-Chloro-1,3-dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one
Oprea1_501459
SCHEMBL27435
Temazepam impurity, oxazepam-
DivK1c_000986
OXAZEPAM [ORANGE BOOK]
GTPL7253
ADIMAYPTOBDMTL-UHFFFAOYSA-
BDBM85031
HMS503E13
KBio1_000986
N05BA04
Oxazepam 0.1 mg/ml in Methanol
Oxazepam 1.0 mg/ml in Methanol
NINDS_000986
Oxazepam, 1mg/ml in Acetonitrile
52432-54-9
NSC_4616
Tox21_111572
Tox21_112819
Tox21_200700
Tox21_303501
7-Chloro-1,4-benzodiazepine-2-one
AKOS016347293
DB00842
FO26616
2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-3-hydroxy-5-phenyl-, (+-)-
IDI1_000986
WLN: T67 GMV JN IHJ CG IQ KR
NCGC00159323-04
NCGC00257352-01
NCGC00258254-01
CAS_604-75-1
DB-242912
NS00007748
C07359
D00464
Q412299
SR-01000942251
2H-1, 7-chloro-1,3-dihydro-3-hydroxy-5-phenyl-
7-chloro-5-phenyl-3H-1,4-benzodiazepine-2,3-diol
SR-01000942251-1
TEMAZEPAM IMPURITY, OXAZEPAM- [USP IMPURITY]
TEMAZEPAM IMPURITY, OXAZEPAM-(USP IMPURITY)
7-Chloro-3-hydroxy-5-phenyl-1,4-benzodiazepin-2-one
BRD-A50049929-001-01-9
Oxazepam, European Pharmacopoeia (EP) Reference Standard
3-hydroxy-1,3-dihydro-7-chloro-5-phenyl-2H-1,4-benzodiazepin-2-one
3-hydroxy-5-phenyl-7-chloro-2,3-dihydro-1H-1,4-benzodiazepin-2-one
7-Chloro-3-hydroxy-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one
7-chloro-3-hydroxy-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one
(+/-)-7-CHLORO-1,3-DIHYDRO-3-HYDROXY-5-PHENYL-2H-1,4-BENZODIAZEPIN-2-ONE
Oxazepam for peak identification, European Pharmacopoeia (EP) Reference Standard
210-076-9
InChI=1/C15H11ClN2O2/c16-10-6-7-12-11(8-10)13(9-4-2-1-3-5-9)18-15(20)14(19)17-12/h1-8,15,20H,(H,17,19)
Solubility of 7-chloro-3-hydroxy-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one
The solubility of 7-chloro-3-hydroxy-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one (C16H11ClN4O2) can be influenced by several factors that are crucial for understanding its behavior in various solvents.
Solubility Characteristics
This compound is known to exhibit some intriguing solubility properties:
In general, it is expected that 7-chloro-3-hydroxy-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one would be moderately soluble in water due to its structure, while being more soluble in organic solvents. This dual-solubility profile allows it to be used in diverse chemical environments.
To summarize: The solubility of the compound is intricately tied to its molecular structure, and understanding these relationships is essential for various applications in both research and industry.