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Chlortalidone

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Identification
Molecular formula
C14H11ClN2O4S
CAS number
77-36-1
IUPAC name
7-chloro-3-methyl-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine 1,1-dioxide
State
State
Chlortalidone is a solid at room temperature.
Melting point (Celsius)
228.00
Melting point (Kelvin)
501.15
Boiling point (Celsius)
376.60
Boiling point (Kelvin)
649.80
General information
Molecular weight
338.77g/mol
Molar mass
338.7700g/mol
Density
1.2673g/cm3
Appearence

Chlortalidone is a white to yellowish-white, crystalline powder.

Comment on solubility

Solubility of 7-chloro-3-methyl-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine 1,1-dioxide

The solubility of 7-chloro-3-methyl-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine 1,1-dioxide (C14H11ClN2O4S) can be influenced by several factors:

  • Polarity: The presence of polar functional groups such as chlorine and sulfonyl (SO2) groups enhances the compound's ability to interact with polar solvents.
  • Solvent Type: This compound is generally more soluble in polar aprotic solvents like dimethyl sulfoxide (DMSO) and dimethylformamide (DMF) rather than in nonpolar solvents.
  • Temperature: Solubility can increase with temperature, as higher kinetic energy usually helps disrupt solute-solute interactions.

It is important to note that while solubility can vary between different solvents, it is often observed that benzothiadiazine derivatives exhibit limited water solubility, making them challenging to formulate in aqueous systems. As such, when working with this compound, appropriate consideration should be given to the choice of solvents for desired applications.

In summary, understanding the solubility characteristics of this compound plays a crucial role in its practical applications, as well as its behavior in biological systems.

Interesting facts

Interesting Facts about 7-Chloro-3-methyl-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine 1,1-dioxide

7-Chloro-3-methyl-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine 1,1-dioxide, commonly referred to as a type of benzothiadiazine, is a fascinating compound with several intriguing properties and applications:

  • Pharmacological Potential: This compound is particularly notable for its role in medicinal chemistry. Various derivatives of benzothiadiazines have been studied for their therapeutic potential, particularly as diuretics and antihypertensives.
  • Structural Uniqueness: The unique structure of this compound, characterized by the presence of both a chlorine atom and a methyl group attached to the benzothiadiazine core, contributes to its chemical reactivity and biological activity. The positioning of these substituents makes it an interesting subject for structure-activity relationship studies.
  • Environmental Relevance: Compounds like 7-chloro-3-methyl-3,4-dihydro-benzothiadiazines can have significant environmental implications, particularly in agricultural applications as herbicides or as part of plant protection solutions.
  • Research Interest: Ongoing research into the compound and its derivatives continues to yield important findings that could impact drug development and agricultural science. Scientists are particularly keen on exploring its interaction with various biological targets.
  • Mechanism of Action: Insight into its mechanism of action reveals that compounds from this class often operate through inhibiting specific enzymes or receptors, which furthers the understanding of their roles in physiological processes.

As an engaging area of study, the exploration of 7-chloro-3-methyl-3,4-dihydro-benzothiadiazine opens avenues for both fundamental research and practical applications. It remains a vital compound in the continuous advancement of chemistry and its applications in health and the environment.

Synonyms
22503-72-6
Idra-21
idra 21
7-Chloro-3-methyl-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide
7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide
7-Chloro-3,4-dihydro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
689UW7PT68
C8H9ClN2O2S
IDRA21
163936-78-5
163936-79-6
MFCD00270874
7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide
7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-S,S-dioxide
7-chloro-3-methyl-3-4-dihydro-2h-1,2,4 benzothiadiazine s,s-dioxide
2H-1,2,4-Benzothiadiazine, 7-chloro-3,4-dihydro-3-methyl-, 1,1-dioxide
7-chloro-3-methyl-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-1,1-dione
7-chloro-3-methyl-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine 1,1-dioxide
7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-BENZO(E)(1,2,4)THIADIAZINE 1,1-DIOXIDE
7-Chloro-3,4-dihydro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-Dioxide;
7-chloro-3-methyl-3,4-dihydro-2H-1$l^(6),2,4-benzothiadiazine-1,1-dione
(+)-IDRA-21
(-)-IDRA-21
Biomol-NT_000225
CHEMBL77862
SCHEMBL195328
UNII-689UW7PT68
BPBio1_001088
GTPL4219
DTXSID70936887
EX-A737
CHEBI:111162
HMS3267D13
HMS3412O19
HMS3676O19
BCP19065
HB0334
s2434
AKOS024456473
IDRA 21, >=98%
2H-1,2,4-Benzothiadiazine, 7-chloro-3,4-dihydro-3-methyl-, 1,1-dioxide, (+)-
2H-1,2,4-Benzothiadiazine, 7-chloro-3,4-dihydro-3-methyl-, 1,1-dioxide, (-)-
NCGC00025050-02
DA-49967
DS-11824
SY105342
HY-101528
CS-0021632
SR-01000597374
Q5970086
SR-01000597374-1
BRD-A14344385-001-01-6
BRD-A14344385-001-02-4
BRD-A14344385-001-03-2
7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine
S 18986;S18986;IDRA-21;IDRA21;IDRA 21;AMPAKINE
7-Chloro-3-methyl-3,4-dihydro-1lambda6,2,4-benzothiadiazine-1,1(2H)-dione, (+)-
7-chloro-3-methyl-3,4-dihydro-2H-1$l^{6,2,4-benzothiadiazine 1,1-dioxide
839-213-6