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7-Chloro-3,4-dihydro-1H-2,3-benzoxazine

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Identification
Molecular formula
C8H8ClNO
CAS number
2918-97-2
IUPAC name
7-chloro-3,4-dihydro-1H-2,3-benzoxazine
State
State

At room temperature, 7-Chloro-3,4-dihydro-1H-2,3-benzoxazine is typically a solid. It is stable under normal conditions but should be stored in a cool, dry place to maintain its structural integrity.

Melting point (Celsius)
89.50
Melting point (Kelvin)
362.65
Boiling point (Celsius)
295.00
Boiling point (Kelvin)
568.15
General information
Molecular weight
169.61g/mol
Molar mass
169.6010g/mol
Density
1.2473g/cm3
Appearence

The compound typically appears as a solid with crystalline form. The exact color can vary slightly depending on the specific conditions and purity of the sample, but it is usually white or off-white.

Comment on solubility

Solubility of 7-chloro-3,4-dihydro-1H-2,3-benzoxazine

7-chloro-3,4-dihydro-1H-2,3-benzoxazine exhibits intriguing solubility properties that can be influenced by various factors.

Solubility Characteristics:

  • Polarity: The presence of both chloro groups and benzoxazine moieties suggests a moderate polarity. This can enhance solubility in polar solvents.
  • Solvent Compatibility: It is often more soluble in organic solvents like ethanol and acetone compared to nonpolar solvents.
  • Temperature Influence: Solubility may increase with temperature, a common characteristic observed in many organic compounds.
  • pH Dependency: Changes in pH can also affect solubility, particularly if ionizable groups are present.

In summary, while the solubility of 7-chloro-3,4-dihydro-1H-2,3-benzoxazine is not universally high, its solubility in various solvents can be optimized under specific conditions. Understanding these properties is essential for its application in chemical processes and formulations.

Interesting facts

Interesting Facts about 7-Chloro-3,4-dihydro-1H-2,3-benzoxazine

7-Chloro-3,4-dihydro-1H-2,3-benzoxazine is a fascinating compound that falls within the realm of heterocyclic chemistry. This class of compounds is characterized by their unique structure, containing atoms of at least two different elements as part of a ring. Here are some intriguing points about this specific compound:

  • Pharmaceutical Potential: Benzoxazines, including this compound, have shown promising results in medicinal chemistry, often being explored for their anti-inflammatory and antimicrobial properties.
  • Synthetic Utility: The synthesis of this compound involves innovative chemical strategies, making it a subject of interest for organic chemists interested in developing novel synthetic methods.
  • Structural Features: The fused benzene and oxazine rings provide distinct reactivity patterns, which can lead to a variety of chemical transformations.
  • Research Interest: There is ongoing research regarding the derivatives of benzoxazine, with many studies aimed at modifying their structure to enhance biological activity or to tailor them for specific industrial applications.

According to a recent study, "the versatility of benzoxazines allows for substantial modification of their structure while maintaining core biological activity," emphasizing their potential as lead compounds in drug development.

In conclusion, the exploration of 7-chloro-3,4-dihydro-1H-2,3-benzoxazine serves not just as a journey into synthetic chemistry but also opens doors to understanding its implications in various fields, including pharmacology and material science. As the field advances, compounds like these continue to inspire scientists worldwide.

Synonyms
7-Chloro-3,4-dihydro-1H-2,3-benzoxazine
21977-12-8
BRN 1103558
1H-2,3-BENZOXAZINE, 3,4-DIHYDRO-7-CHLORO-
1H-2,3-Benzoxazine, 7-chloro-3,4-dihydro-
DTXSID30176383
RefChem:237280
DTXCID7098874