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Clonazolam

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Identification
Molecular formula
C17H12ClN5O1
CAS number
33887-02-4
IUPAC name
7-chloro-4-hydroxy-5-phenyl-3H-1,4-benzodiazepin-2-imine
State
State

At room temperature, clonazolam is a solid substance. It is usually handled as a powder or a crystalline solid in laboratory settings.

Melting point (Celsius)
140.00
Melting point (Kelvin)
413.00
Boiling point (Celsius)
580.00
Boiling point (Kelvin)
853.00
General information
Molecular weight
353.16g/mol
Molar mass
353.1570g/mol
Density
1.3400g/cm3
Appearence

Clonazolam is typically found as a white to light yellow crystalline powder. It may also appear as a colorless solid in its pure form.

Comment on solubility

Solubility of 7-chloro-4-hydroxy-5-phenyl-3H-1,4-benzodiazepin-2-imine

The solubility of 7-chloro-4-hydroxy-5-phenyl-3H-1,4-benzodiazepin-2-imine in various solvents plays a significant role in its pharmaceutical applications. Here are some key points regarding its solubility:

  • Polar Solvents: It tends to have higher solubility in polar solvents such as water and methanol, indicating the potential for good bioavailability.
  • Non-Polar Solvents: Less soluble in non-polar solvents like hexane, which may affect its interactions in lipid-rich environments.
  • pH Dependence: The solubility may vary considerably with changes in pH due to the presence of the –OH group, which can participate in ionization, influencing its solubility behavior.
  • Complex Formation: It has the potential to form complexes with other compounds that may either enhance or inhibit its solubility.

In conclusion, the solubility of 7-chloro-4-hydroxy-5-phenyl-3H-1,4-benzodiazepin-2-imine is multifaceted and affected by several factors, which must be considered in formulations and biological assessments. Achieving optimal solubility is crucial for maximizing its effectiveness in therapeutic applications.

Interesting facts

Interesting Facts about 7-Chloro-4-Hydroxy-5-Phenyl-3H-1,4-Benzodiazepin-2-Imine

This fascinating compound is a member of the benzodiazepine family, which is renowned for its psychoactive properties. Benzodiazepines primarily act as central nervous system depressants, making them widely used in medical settings, particularly for treating anxiety, insomnia, and seizures. Here are some intriguing aspects of this specific compound:

  • Structure significance: The presence of both the chloro and hydroxy substituents on the benzodiazepine scaffold contributes to its pharmacological properties. These functional groups can significantly affect how the compound interacts with biological targets.
  • Potential applications: Compounds like this one have been researched for their potential in developing new anxiolytics or sedatives, aiming to create medications with fewer side effects compared to traditional benzodiazepines.
  • Mechanism of action: Benzodiazepines typically enhance the effect of the neurotransmitter GABA at the GABAA receptor. This action can lead to increased neuronal inhibition, which underlies their calming effects.
  • Synthetic pathways: The synthesis of 7-chloro-4-hydroxy-5-phenyl-3H-1,4-benzodiazepin-2-imine involves multi-step reactions, showcasing the complexity and creativity required in organic chemistry.
  • Research potential: This compound is a subject of ongoing research, with studies focusing on its efficacy and safety profile as an alternative therapeutic agent.

As a scientist or a student in chemistry, understanding the nuances of compounds like 7-chloro-4-hydroxy-5-phenyl-3H-1,4-benzodiazepin-2-imine is essential not only for their application in medicine but also for appreciating the intricate relationships between molecular structure and biological activity.

In summary, the exploration of this compound opens up avenues for further research and innovation in pharmacotherapy, with the potential to enhance the lives of individuals suffering from various psychological disorders.

Synonyms
7722-15-8
Norchlordiazepoxide
N-Demethylchlordiazepoxide
N-Desmethylchlordiazepoxide
Desmethylchlordiazepoxide
3H-1,4-Benzodiazepin-2-amine, 7-chloro-5-phenyl-, 4-oxide
Ro 5-0883
F7P2N4H0H2
Demethylchlordiazepoxide
7-chloro-4-hydroxy-5-phenyl-3H-1,4-benzodiazepin-2-imine
3H-1,4-Benzodiazepine, 2-amino-7-chloro-5-phenyl-, 4-oxide
DTXSID10227968
2-Amino-7-chloro-5-phenyl-3H-1,4-benzodiazepine 4-oxide
7-Chloro-2-amino-5-phenyl-3H-1,4-benzodiazepine 4-oxide
7-Chloro-5-phenyl-3H-1,4-benzodiazepin-2-amine 4-oxide
J14.781H
RO-5-0883
(2z)-7-chloro-2-imino-5-phenyl-2,3-dihydro-4h-1,4-benzodiazepin-4-ol
RO 5-0883/1
3H-1,4-BENZODIAZEPIN-2-AMINE, 7-CHLORO-5-PHENYL-, 4-OXIDE, HYDROCHLORIDE
DTXCID40206802
N-Demethyl Chlordiazepoxide
UNII-F7P2N4H0H2
N-Demethyl Chlordiazepoxide (1.0 mg/mL in 20% DMSO in Acetonitrile)
DEMETHYL-CHLORDIAZEPOXIDE
CHEMBL2260845
Q27277770