Interesting facts
Interesting Facts about 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one
The compound 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one is a fascinating member of the benzodiazepine family, which is well-known for its anxiolytic, sedative, and muscle-relaxing properties. Here are some intriguing points to consider:
- Pharmacological Applications: This compound, like many benzodiazepines, plays a significant role in medicine. Benzodiazepines are primarily used to treat anxiety, insomnia, and certain types of seizures.
- Chlorine Substituents: The presence of chlorine atoms in its structure enhances its pharmacological activity and potency. This highlights the importance of molecular modifications in drug design.
- Hydroxy Group Influence: The hydroxy group at position 3 is crucial; it often influences the compound's interaction with biological targets and enhances its solubility.
- Synthetic Interest: Chemists are continuously exploring various synthetic routes to develop derivatives of this compound, aiming to improve efficacy and minimize side effects.
- Structure-Activity Relationship (SAR): The study of this compound exemplifies SAR in medicinal chemistry, providing insights on how structural changes can affect biological activity.
This compound embodies the delicate balance between chemistry and pharmacology, illustrating how modifications at the molecular level lead to significant therapeutic benefits. As a student or researcher, understanding the complexities of such compounds can enhance your knowledge of drug development and the intricate workings of medicinal chemistry.
In the words of a well-known chemist, "The beauty of chemistry lies in its structure and the stories it tells about interactions and functions." This compound is a perfect example of such stories, bridging the gap between chemical structure and biological function.
Synonyms
lorazepam
Ativan
846-49-1
o-Chloroxazepam
o-Chlorooxazepam
Temesta
Loraz
Bonatranquan
Anxiedin
Lorabenz
Sedatival
Orfidal
Punktyl
Quait
Tavor
Delormetazepam
Almazine
Aplacasse
Aplacassee
Azurogen
Duralozam
Efasedan
Emotival
Kalmalin
Lorazene
Lorazepam Intensol
Lorsedal
Novhepar
Renaquil
Rocosgen
Sedizepan
Tranqipam
Anxira
Anzepam
Aripax
Bonton
Equitam
Larpose
Laubeel
Lorapam
Lorazep
Lorazin
Lorenin
Loridem
Lozepam
Merlit
Sidenar
Silence
Stapam
Trapax
Loram
Lorat
Lorax
Wypax
Upan
Apo-Lorazepam
Nervistop L
Lorazepamum
Nervistopl
Norlormetazepam
Novolorazem
Emotion
Lomesta
Lorafen
Lorazon
Lorivan
Vigiten
Lopam
Lorans
Lorzem
Lorazepam Fabra
Lorazepam-Efeka
Lorazepan Chobet
Lorazepan Richet
Wy-4036
Max Pax
Demethyllormetazepam
Lorazepam Genericon
Lorazepam Lannacher
Wy 4036
Lorazepam preservative free
(+/-)-Lorazepam
Lorazepam civ
7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one
Lorazepamum [INN-Latin]
2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-
NSC 289758
EINECS 212-687-6
UNII-O26FZP769L
BRN 0759084
Idalprem
O26FZP769L
DTXSID7023225
LOREEV XR
7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one
7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one
Sinestron
NSC289758
Donix
Tolid
CHEMBL580
7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1H-1,4-benzodiazepin-2(3H)-one
Lorazepam Medical
Nu Loraz
DTXCID303225
Somagerol
5-25-02-00248 (Beilstein Handbook Reference)
Lorazepam [USAN:USP:INN:BAN:JAN]
NSC-289758
NCGC00159439-02
Lorsilan
Securit
Sedazin
Lorazepamum (INN-Latin)
Pro dorm
LORAZEPAM (MART.)
LORAZEPAM [MART.]
2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-
LORAZEPAM (EP IMPURITY)
LORAZEPAM [EP IMPURITY]
LORAZEPAM CIV (USP-RS)
LORAZEPAM CIV [USP-RS]
LORAZEPAM (EP MONOGRAPH)
LORAZEPAM [EP MONOGRAPH]
LORAZEPAM (USP MONOGRAPH)
LORAZEPAM [USP MONOGRAPH]
Lorazepam (USAN:USP:INN:BAN:JAN)
(+/-)-7-CHLORO-5-(O-CHLOROPHENYL)-1,3-DIHYDRO-3-HYDROXY-2H-1,4-BENZODIAZEPIN-2-ONE
7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one
Lorazepam (1.0 mg/mL in Acetonitrile)
Lorazepam (100 ug/mL in Acetonitrile)
2H-1,4-BENZODIAZEPIN-2-ONE, 7-CHLORO-5-(2-CHLOROPHENYL)-1,3-DIHYDRO-3-HYDROXY-, (+/-)-
Ativan (TN)
Loracepam
DEA No. 2885
LORAZEPAM [INN]
LORAZEPAM [JAN]
LORAZEPAM [MI]
LORAZEPAM [USAN]
(.+/-.)-Lorazepam
LORAZEPAM [VANDF]
LORAZEPAM [WHO-DD]
(+-)-7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one
SCHEMBL26961
MLS001424236
DivK1c_000965
Lorazepam (JP18/USP/INN)
CHEBI:6539
GTPL5884
LORAZEPAM [ORANGE BOOK]
HMS503A11
KBio1_000965
N05BA06
NINDS_000965
HMS2052H07
HMS3394H07
Lorazepam, 1mg/ml in Acetonitrile
BCP13713
Tox21_111669
BDBM50292627
Lorazepam 0.1 mg/ml in Acetonitrile
Lorazepam 1.0 mg/ml in Acetonitrile
AKOS015904303
CCG-101170
DB00186
FL24937
NC00420
2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-, (+-)-
IDI1_000965
CAS-846-49-1
SMR000058410
WLN: T67 GMV JN IHJ CG IQ KR BG
NS00000034
D00365
A840886
Q408265
7-Chloro-5-(o-chlorophenyl)-1,4-benzodiazepin-2-one
BRD-A11990600-001-01-8
BRD-A11990600-001-03-4
Lorazepam, British Pharmacopoeia (BP) Reference Standard
Lorazepam, European Pharmacopoeia (EP) Reference Standard
2H-1, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-
2H-1, 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-
Lorazepam, United States Pharmacopeia (USP) Reference Standard
O-Chloroxazepam; O-Chlorooxazepam; Almazine; WY 4036; WY-4036; WY4036
(3RS)-7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one
7-chloranyl-5-(2-chlorophenyl)-3-oxidanyl-1,3-dihydro-1,4-benzodiazepin-2-one
7-chloro-3-hydroxy-5-(2'-chloro-phenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-one
7-chloro-3-hydroxy-5-(2'-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-one
7-Chloro-5-(2-chloro-phenyl)-3-hydroxy-1,3-dihydro-benzo[e][1,4]diazepin-2-one
7-Chloro-5-(2-chlorophenyl)-1, 3-Dihydro-3-Hydroxy-1,4-Benzodiazepin-2-one
7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one #
7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1H-benzo[e][1,4]diazepin-2(3H)-one
7-chloro-5-(2-chlorophenyl)-3-hydroxy-2,3-dihydro-1H-1,4-benzodiazepin-2-one
Lorazepam for system suitability, European Pharmacopoeia (EP) Reference Standard
LORAZEPAM7-Chloro-5-(2-chloro-phenyl)-3-hydroxy-1,3-dihydro-benzo[e][1,4]diazepin-2-one
(RS)-9-chloro-6-(2-chlorophenyl)-4-hydroxy-2,5-diazabicyclo[5.4.0]undeca-5,8,10,12-tetraen-3-one
212-687-6
7-Chloro-5-(2-chloro-phenyl)-3-hydroxy-1,3-dihydro-benzo[e][1,4]diazepin-2-one (lorazepam)
7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one;Ativan;Emotival
Solubility of 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one
The solubility of 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one, with chemical formula C15H10Cl2N2O2, can exhibit some interesting characteristics. Understanding the solubility behavior of this compound is crucial for its applications in medicinal chemistry and pharmacology.
Key Factors Affecting Solubility
The solubility of this compound can be influenced by various factors:
General Observations
Although specific quantitative solubility data for this compound is not readily available, general trends suggest that:
In conclusion, while precise solubility values could provide deeper insights, the solubility properties of C15H10Cl2N2O2 are subject to the interplay of structural features and solvent interactions. Understanding these parameters remains vital for practical applications in research and industry.