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Lorazepam

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Identification
Molecular formula
C15H10ClFN2O2
CAS number
846-49-1
IUPAC name
7-chloro-5-(2-fluorophenyl)-1-[2-(4-methylpiperazin-1-yl)ethyl]-3H-1,4-benzodiazepin-2-one
State
State

At room temperature, Lorazepam is in a solid state, typically found as a crystalline powder.

Melting point (Celsius)
166.00
Melting point (Kelvin)
439.15
Boiling point (Celsius)
517.30
Boiling point (Kelvin)
790.50
General information
Molecular weight
321.77g/mol
Molar mass
321.7660g/mol
Density
1.3000g/cm3
Appearence

Lorazepam is typically a white or practically white crystalline powder. It is almost odorless.

Comment on solubility

Solubility of 7-chloro-5-(2-fluorophenyl)-1-[2-(4-methylpiperazin-1-yl)ethyl]-3H-1,4-benzodiazepin-2-one

The solubility of 7-chloro-5-(2-fluorophenyl)-1-[2-(4-methylpiperazin-1-yl)ethyl]-3H-1,4-benzodiazepin-2-one can be explored from several angles. Its solubility profile is influenced by multiple factors:

  • Polarity: The presence of various functional groups such as chloro, fluoro, and piperazinyl impacts its solubility in different solvents. Generally, more polar compounds tend to be more soluble in polar solvents like water.
  • Hydrogen Bonding: The capability of the compound to engage in hydrogen bonding can enhance solubility, particularly in polar solvents.
  • Temperature: Solubility often increases with temperature, so evaluating solubility at various temperatures may yield different results.
  • pH dependence: Since it is a benzodiazepine derivative, changes in pH can affect the ionization states of the compound, thus influencing its solubility in aqueous media.

Generally speaking, compounds with similar structures may exhibit poor water solubility yet can be more soluble in organic solvents. "Hydrophobic interactions" often play a significant role for substances in biological systems, leading to variable absorption characteristics.

Overall, the solubility of this compound is a complex interplay of various physicochemical properties, making it essential to conduct experimental analysis for precise assessment.

Interesting facts

Interesting Facts about 7-chloro-5-(2-fluorophenyl)-1-[2-(4-methylpiperazin-1-yl)ethyl]-3H-1,4-benzodiazepin-2-one

This compound belongs to the benzodiazepine class of medications, which are widely recognized for their use in treating various conditions related to anxiety and insomnia. Here are some noteworthy aspects of this intriguing compound:

  • Structure and Function: The unique structure of this compound features a chlorinated benzodiazepine framework, which contributes to its pharmacological properties.
  • Pharmacological Activity: Benzodiazepines are well-known for their ability to enhance the effect of the neurotransmitter GABA, which is crucial for inhibiting neural activity and promoting relaxation.
  • Selectivity: The presence of the fluorophenyl group may augment selective binding to particular GABA receptors, potentially leading to varied psychoactive effects.
  • Research Potential: The modification of the piperazine moiety in this structure may lead to increased bioavailability and improved therapeutic profiles compared to traditional benzodiazepines.
  • Clinical Relevance: Investigations into compounds like this one are vital as they offer new insights into designing medications with reduced side effects and better safety profiles.

As noted by researchers, "The future of anxiety treatment lies in the precision of compounds like these, balancing efficacy and safety." The ongoing studies surrounding benzodiazepine derivatives enrich our understanding of their impact on mental health therapies.

In conclusion, the sophisticated design and potential applications of 7-chloro-5-(2-fluorophenyl)-1-[2-(4-methylpiperazin-1-yl)ethyl]-3H-1,4-benzodiazepin-2-one underscore the importance of innovative approaches in medicinal chemistry. Each modification in the compound can significantly affect its pharmacodynamics and pharmacokinetics, opening doors for novel therapeutic interventions.