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Diazepam

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Identification
Molecular formula
C16H13ClFN3O1
CAS number
439-14-5
IUPAC name
7-chloro-5-(2-fluorophenyl)-1-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]-3H-1,4-benzodiazepin-2-one
State
State

At room temperature, diazepam is in a solid state. It is typically encountered as a crystalline compound that remains stable under ambient conditions, though sensitive to light.

Melting point (Celsius)
131.00
Melting point (Kelvin)
404.15
Boiling point (Celsius)
550.00
Boiling point (Kelvin)
823.15
General information
Molecular weight
284.75g/mol
Molar mass
284.7480g/mol
Density
1.3000g/cm3
Appearence

Diazepam is typically seen as a solid, crystalline substance that is colorless to light yellow in appearance. It can be found in the form of tablets or a powder that may have a slight off-white shade.

Comment on solubility

Solubility of 7-chloro-5-(2-fluorophenyl)-1-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]-3H-1,4-benzodiazepin-2-one

The solubility of 7-chloro-5-(2-fluorophenyl)-1-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]-3H-1,4-benzodiazepin-2-one can be influenced by several factors, primarily its chemical structure and the presence of functional groups. Understanding the solubility characteristics of this compound is essential for its practical application in fields such as pharmaceuticals.

Key Factors Influencing Solubility:

  • Polar Functional Groups: The presence of polar functional groups, such as hydroxyl (–OH), can enhance solubility in polar solvents.
  • Hydrophobic Regions: Hydrophobic aromatic rings may reduce solubility in water but can improve solubility in organic solvents.
  • Ionization: The degree of ionization of the compound in solution plays a critical role, particularly in aqueous environments.

In general, benzodiazepines like this compound tend to exhibit varied solubility:

  1. Highly soluble in organic solvents (e.g., ethanol, DMSO).
  2. Variable solubility in water, largely influenced by pH and the ionic state of the compound.

As a result, it is often quoted that the "solubility behavior of complex organic molecules" offers a unique challenge for formulation scientists. Therefore, it is crucial to conduct precise solubility studies to ensure optimal formulation and therapeutic efficacy. Understanding these nuances allows for the development of effective dosage forms that can significantly impact the pharmacokinetics of the compound.

Interesting facts

Interesting Facts about 7-Chloro-5-(2-fluorophenyl)-1-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]-3H-1,4-benzodiazepin-2-one

This compound is a notable member of the benzodiazepine family, which is widely recognized for its therapeutic applications. Here are some fascinating aspects of this chemical:

  • Pharmacological Significance: As a benzodiazepine derivative, this compound exhibits potential anxiolytic, sedative, and muscle relaxant properties. Benzodiazepines are commonly used in the treatment of anxiety disorders and insomnia, showcasing the relevance of compounds like this in medicinal chemistry.
  • Structural Complexity: The molecule features a unique structure with multiple functional groups, including a piperazine ring and a fluorophenyl moiety. This complexity contributes to its biological activity and highlights the importance of structural variations in drug design.
  • Developmental Insights: Research suggests that modifications to the benzodiazepine core can lead to enhanced binding affinity to the gamma-aminobutyric acid (GABA) receptor, increasing the effectiveness of the compound as a central nervous system depressant.
  • Potential for Novel Therapies: Scientists are continuously investigating compounds like this for their potential role in treating various medical conditions, ranging from anxiety and depression to neurodegenerative diseases.
  • Synergistic Effects: The presence of the 2-hydroxyethyl group may offer opportunities for synergistic pharmacological effects when combined with other therapeutic agents in polypharmacy treatments, improving patient outcomes.

In conclusion, the intricacies of 7-chloro-5-(2-fluorophenyl)-1-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]-3H-1,4-benzodiazepin-2-one illustrate the captivating world of medicinal chemistry where innovation and research continue to pave the way for advanced therapeutic solutions.