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Clonazepam

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Identification
Molecular formula
C15H10ClFN2O
CAS number
1622-61-3
IUPAC name
7-chloro-5-(2-fluorophenyl)-1-[3-(methylamino)propyl]-3H-1,4-benzodiazepin-2-one
State
State

Clonazepam is a solid at room temperature. It is generally formulated into tablets for oral administration in clinical settings.

Melting point (Celsius)
236.50
Melting point (Kelvin)
509.60
Boiling point (Celsius)
564.30
Boiling point (Kelvin)
837.50
General information
Molecular weight
315.71g/mol
Molar mass
315.7140g/mol
Density
1.5440g/cm3
Appearence

Clonazepam typically appears as a white to light yellow crystalline powder. It is known for its purity and consistency in the pharmaceutical industry.

Comment on solubility

Solubility of 7-chloro-5-(2-fluorophenyl)-1-[3-(methylamino)propyl]-3H-1,4-benzodiazepin-2-one

The solubility of 7-chloro-5-(2-fluorophenyl)-1-[3-(methylamino)propyl]-3H-1,4-benzodiazepin-2-one is influenced by its molecular structure and the functional groups present. As a benzodiazepine derivative, its solubility can be characterized by several factors:

  • Polar vs. Non-Polar Characteristics: The presence of polar functional groups often enhances solubility in polar solvents, while hydrophobic regions may favor solubility in non-polar solvents.
  • Hydrogen Bonding: This compound's ability to form hydrogen bonds with solvents can significantly affect its overall solubility.
  • pH Dependency: The solubility may vary with pH, as ionization of the amine group can make the compound more soluble in acidic or basic solutions.
  • Solvent Choice: Common solvents used for testing solubility include water, ethanol, and dimethyl sulfoxide (DMSO). Each can yield different solubility profiles.

In general, due to its complex structure, this compound may exhibit limited solubility in aqueous environments, making organic solvents more favorable for solubility testing. As with many pharmaceutical compounds, understanding the solubility is crucial for developing effective formulations for therapeutic use. It is worth noting that, as stated, "A compound's solubility is key to its bioavailability," which emphasizes the importance of thorough investigation into solubility characteristics.

Interesting facts

Interesting Facts About 7-chloro-5-(2-fluorophenyl)-1-[3-(methylamino)propyl]-3H-1,4-benzodiazepin-2-one

This compound belongs to the class of benzodiazepines, which are widely known for their therapeutic uses. Here's what makes this particular compound noteworthy:

  • Therapeutic Applications: Like many benzodiazepines, this compound is potentially useful in the treatment of anxiety and sleep disorders. Its unique structure may provide specific benefits, including *lower side effects* or *enhanced efficacy* when compared to other compounds in the same class.
  • Structural Features: The presence of both a chlorine atom and a fluorine atom in its structure gives this compound distinct electronic properties. These halogen substitutions can influence the compound's biological activity, making it an interesting subject for drug design.
  • Research Interest: Due to its complex structure, this compound is often of interest in medicinal chemistry research. Scientists investigate how subtle changes in the molecular structure can affect pharmacodynamics and pharmacokinetics, paving the way for more effective treatments.
  • Potential Challenges: While there is strong interest in benzodiazepines, compounds like this one can also present challenges, such as the potential for dependence and withdrawal symptoms. Researchers continually evaluate the risk-benefit profile associated with using these types of medications.
  • Future Directions: The study of benzodiazepines is a dynamic field. Ongoing research aims to discover *novel derivatives* that might offer enhanced safety and effectiveness while minimizing risks. This compound could play a role in developing safer therapeutic options.

In conclusions, 7-chloro-5-(2-fluorophenyl)-1-[3-(methylamino)propyl]-3H-1,4-benzodiazepin-2-one embodies the intricate relationship between structure and function in drug development. The evolution of such compounds continues to be vital in the quest for advanced therapeutic solutions.