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Diazepam

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Identification
Molecular formula
C16H14ClFN2O
CAS number
439-14-5
IUPAC name
7-chloro-5-(2-fluorophenyl)-1-[3-(methylamino)propyl]-3H-1,4-benzodiazepin-2-one;dihydrochloride
State
State

Diazepam in its dihydrochloride form is a solid at room temperature, being commonly available as a crystalline powder in pharmaceutical settings. It is relatively stable under ambient conditions.

Melting point (Celsius)
131.50
Melting point (Kelvin)
404.65
Boiling point (Celsius)
257.00
Boiling point (Kelvin)
530.15
General information
Molecular weight
284.74g/mol
Molar mass
284.7360g/mol
Density
1.0400g/cm3
Appearence

Diazepam, as its dihydrochloride salt, typically appears as a white to off-white crystalline powder. It's known for its high purity in pharmaceutical formulations and is both odorless and tasteless.

Comment on solubility

Solubility of 7-chloro-5-(2-fluorophenyl)-1-[3-(methylamino)propyl]-3H-1,4-benzodiazepin-2-one Dihydrochloride

The solubility of 7-chloro-5-(2-fluorophenyl)-1-[3-(methylamino)propyl]-3H-1,4-benzodiazepin-2-one dihydrochloride is influenced by several key factors, primarily due to its ionic nature and the presence of functional groups. Here are some notable points regarding its solubility:

  • In Water: This compound is likely to have high solubility in aqueous environments due to the presence of two hydrochloride (HCl) groups which typically enhances solubility by promoting ionization.
  • In Organic Solvents: Solubility may vary significantly in organic solvents depending on their polarity. Non-polar solvents may exhibit lower solubility.
  • pH Dependence: The solubility can vary with pH changes, particularly in acidic or basic solutions, due to the ionizable amine group which can protonate or deprotonate.
  • Temperature Influence: Warming the solution might enhance solubility as higher temperatures often increase kinetic energy, leading to improved dissolving rates for ionic solids.

In conclusion, while the compound displays a general trend of increased solubility in polar solvents, the specifics can be influenced by environmental conditions. As one expert put it, “Understanding the solubility profile of such compounds is crucial for their pharmaceutical applications.” Thus, emphasizing the importance of conducting thorough solubility assessments in different conditions.

Interesting facts

Interesting Facts about 7-Chloro-5-(2-fluorophenyl)-1-[3-(methylamino)propyl]-3H-1,4-benzodiazepin-2-one Dihydrochloride

This compound belongs to the benzodiazepine class, which is well-known for its psychoactive properties. Benzodiazepines are commonly used in medicine for their anxiolytic, sedative, and anticonvulsant effects. Here are some facts that illustrate its significance:

  • Mechanism of Action: Benzodiazepines like this compound work by enhancing the effect of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABAA receptor, leading to increased neuronal inhibition.
  • Potential Applications: This specific compound may be explored for therapeutic use in anxiety disorders, insomnia, and certain types of seizures, showcasing the versatility of benzodiazepines in clinical settings.
  • Research Insights: Studies on compounds like this can contribute to understanding the intricate balance of anxiety and depression in mental health, potentially paving the way for new treatments.
  • Safety Profile: Like other benzodiazepines, understanding the side effects and potential for dependence is crucial when considering this compound for therapeutic applications.

In conclusion, while 7-chloro-5-(2-fluorophenyl)-1-[3-(methylamino)propyl]-3H-1,4-benzodiazepin-2-one dihydrochloride might seem complex, it symbolizes the ongoing research and development in the field of medicinal chemistry. It's a reminder that every compound holds potential, both in pharmacological applications and in our quest to understand mental health.

Synonyms
4196-18-3
2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1-(3-(methylamino)propyl)-, dihydrochloride
DTXSID40884043
2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-(o-fluorophenyl)-1-(3-(methylamino)propyl)-, dihydrochloride
2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1-(3-(methylamino)propyl)-, hydrochloride (1:2)
2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(o-fluorophenyl)-1,3-dihydro-1-(3-(methylamino)propyl)-, dihydrochloride
2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1-[3-(methylamino)propyl]-, dihydrochloride
2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1-[3-(methylamino)propyl]-, hydrochloride (1:2)
DTXCID501023515
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