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Diazepam

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Identification
Molecular formula
C16H13ClFN3O
CAS number
439-14-5
IUPAC name
7-chloro-5-(2-fluorophenyl)-1-[3-(methylamino)propyl]-4,5-dihydro-3H-1,4-benzodiazepin-2-one
State
State

At room temperature, diazepam is a solid. In its pure form, it is a crystalline powder, but it is often processed into liquid solutions or compressed into tablets for pharmaceutical use.

Melting point (Celsius)
132.00
Melting point (Kelvin)
405.15
Boiling point (Celsius)
301.00
Boiling point (Kelvin)
574.15
General information
Molecular weight
284.74g/mol
Molar mass
284.7440g/mol
Density
1.3060g/cm3
Appearence

Diazepam typically appears as a fine powder or crystalline solid. It is often white to slightly yellow in color. The compound is odorless and has a bitter taste. It may also appear in various forms in pharmaceutical preparations such as tablets and injectable solutions.

Comment on solubility

Solubility of 7-chloro-5-(2-fluorophenyl)-1-[3-(methylamino)propyl]-4,5-dihydro-3H-1,4-benzodiazepin-2-one

The solubility of 7-chloro-5-(2-fluorophenyl)-1-[3-(methylamino)propyl]-4,5-dihydro-3H-1,4-benzodiazepin-2-one can be influenced by a variety of factors, particularly its chemical structure and intermolecular interactions. Here are a few key points to consider:

  • Polarity: The compound exhibits a balance of polar and non-polar characteristics due to the presence of various functional groups, which can affect its solubility in water and organic solvents.
  • Solvent Interaction: It is important to note that the solubility may be higher in polar organic solvents such as methanol and dimethyl sulfoxide (DMSO) compared to non-polar solvents.
  • Acid-Base Properties: The presence of the methylamino group might allow for protonation, which could enhance solubility in acidic conditions.
  • Temperature Dependence: Like many organic compounds, solubility may increase with temperature, meaning higher temperatures may facilitate dissolution.

Overall, understanding the solubility of this compound requires a comprehensive approach, taking into account both its molecular structure and the properties of the solvent used.

Interesting facts

Interesting Facts about 7-Chloro-5-(2-fluorophenyl)-1-[3-(methylamino)propyl]-4,5-dihydro-3H-1,4-benzodiazepin-2-one

7-Chloro-5-(2-fluorophenyl)-1-[3-(methylamino)propyl]-4,5-dihydro-3H-1,4-benzodiazepin-2-one is a fascinating compound in the realm of medicinal chemistry, particularly known for its potential therapeutic applications:

  • Benzodiazepine Structure: This compound belongs to the benzodiazepine class, which is renowned for their psychoactive properties. The benzodiazepine core provides a rich avenue for drug design, contributing to anxiolytic, anticonvulsant, and sedative effects.
  • Cl and F Substituents: The presence of both chlorine and fluorine atoms in the structure often enhances the lipophilicity and biological activity of compounds. The 7-chloro and 2-fluorophenyl substitutions can significantly influence how the compound interacts with biological targets.
  • Methylamino Group: The 3-(methylamino)propyl side chain is noteworthy as the addition of amino groups can improve binding affinity to neuroreceptors, possibly leading to improved efficacy of the compound in clinical settings.
  • Potential in Pharmacology: Research continues to explore this compound's potential use as a therapeutic agent for various conditions, particularly in the management of anxiety disorders and insomnia.

As a student of chemistry, you may find it intriguing to consider how modifications to the molecular structure can lead to significant changes in pharmacological profile and activity. It is also worth noting that the exploration of compounds like this encourages innovative approaches to drug discovery, emphasizing the critical role of aromatic and saturated systems in medicinal chemistry.

“The details in molecular structure often hold the key to therapeutic success,” is a critical takeaway when analyzing compounds in this field. By studying such intricate structures, scientists are paving the way for advancements in drug design and therapeutic applications.