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Clonazepam

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Identification
Molecular formula
C15H10ClFN2O
CAS number
1622-61-3
IUPAC name
7-chloro-5-(2-fluorophenyl)-1-(3-piperazin-1-ylpropyl)-3H-1,4-benzodiazepin-2-one
State
State

Clonazepam is typically found in a solid state at room temperature. It is prescribed in tablet form due to its solid crystalline structure, which allows it to be easily processed and packed for pharmaceutical use.

Melting point (Celsius)
236.50
Melting point (Kelvin)
509.70
Boiling point (Celsius)
743.70
Boiling point (Kelvin)
1 016.90
General information
Molecular weight
315.72g/mol
Molar mass
315.7180g/mol
Density
1.3000g/cm3
Appearence

Clonazepam appears as a light yellow to pale yellow crystalline powder. It is an odorless compound and is notable for its high potency as a psychiatric medication.

Comment on solubility

Solubility of 7-chloro-5-(2-fluorophenyl)-1-(3-piperazin-1-ylpropyl)-3H-1,4-benzodiazepin-2-one

The solubility of 7-chloro-5-(2-fluorophenyl)-1-(3-piperazin-1-ylpropyl)-3H-1,4-benzodiazepin-2-one can be influenced by multiple factors such as temperature, pH, and the presence of solvents. It's essential to understand that:

  • Such compounds often show varying degrees of solubility in organic solvents compared to water.
  • A lower solubility in water and higher solubility in alcohols or dimethyl sulfoxide (DMSO) is common.
  • Factors like ionic interactions and hydrophobic effects can significantly impact solubility.
  • The presence of substituents, such as the chloro and fluoro groups in this compound, may also alter solubility characteristics by influencing the compound's overall polarity.

In conclusion, the solubility of this benzodiazepine derivative reflects its complex structure, making it crucial to utilize appropriate solvents for desired applications in research and drug formulation. As a general guideline, always refer to specific solubility data under controlled conditions for accurate assessments.

Interesting facts

Interesting Facts about 7-chloro-5-(2-fluorophenyl)-1-(3-piperazin-1-ylpropyl)-3H-1,4-benzodiazepin-2-one

This compound is a member of the benzodiazepine family, which is well-known for its pharmacological activity and therapeutic applications. Benzodiazepines are commonly used as anxiolytics, sedatives, and muscle relaxants. Here are some notable facts about this specific compound:

  • Targeted Therapeutics: Due to its unique structure, this compound may target specific GABAA receptors in the brain, enhancing the effects of the neurotransmitter gamma-aminobutyric acid (GABA). This can lead to increased anxiety relief and sedation.
  • Structural Significance: The presence of the chlorine and fluorophenyl groups significantly alters the compound's pharmacokinetics, potentially enhancing its potency and selectivity compared to other benzodiazepines.
  • Piperazine Link: The incorporation of a piperazine moiety allows for increased affinity to various receptors, which might contribute to the compound's effectiveness in treating a wider range of disorders.
  • Research Potential: This compound is of significant interest in medicinal chemistry for developing novel therapeutics, particularly in treating anxiety disorders, depression, and epilepsy.
  • Synergistic Effects: Investigations into its combinations with other compounds may reveal synergistic effects that could enhance therapeutic outcomes while minimizing side effects.

It's fascinating how modifications in chemical structure can lead to profound differences in biological activity. As research continues, compounds like this one pave the way for innovative treatments and a better understanding of neuropharmacology.