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Diazepam

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Identification
Molecular formula
C16H12ClFN2O
CAS number
439-14-5
IUPAC name
7-chloro-5-(2-fluorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one
State
State

At room temperature, Diazepam is typically found in a solid state, often in the form of a crystalline powder. It is stable under normal handling and storage conditions.

Melting point (Celsius)
131.00
Melting point (Kelvin)
404.15
Boiling point (Celsius)
350.30
Boiling point (Kelvin)
623.45
General information
Molecular weight
284.71g/mol
Molar mass
284.7050g/mol
Density
1.3060g/cm3
Appearence

Diazepam usually appears as a fine crystalline powder. It is typically white or off-white in color. The compound may also be available in various pharmaceutical forms, such as tablets or as a liquid for intramuscular or intravenous injection.

Comment on solubility

Solubility of 7-chloro-5-(2-fluorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one

The solubility of 7-chloro-5-(2-fluorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one can be influenced by several factors, making it a compound of interest in the field of medicinal chemistry. Understanding its solubility is crucial for its potential applications. Here are some key points regarding its solubility:

  • Polarity: The presence of both chloro and hydroxy groups likely increases the compound's polarity, enhancing its solubility in polar solvents.
  • Solvent Interaction: It may exhibit higher solubility in aqueous solutions due to hydrogen bonding opportunities provided by the hydroxy group.
  • Structural Considerations: Steric hindrance from the attached phenyl group could alter solubility characteristics, potentially making it less soluble in non-polar solvents.
  • pH Dependence: The solubility may change with pH levels, as ionization of the hydroxy group can affect overall solubility.

In summary, while specific solubility data is essential for exact formulations, the interactions of chemical functional groups, solvent types, and environmental conditions play significant roles in determining the solubility profile of 7-chloro-5-(2-fluorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one.

Interesting facts

Interesting Facts About 7-chloro-5-(2-fluorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one

This compound belongs to the benzodiazepine family, known for their numerous applications in medicine, particularly as anxiolytics, sedatives, and muscle relaxants. Here are some key points to consider:

  • Pharmacological Importance: Compounds in the benzodiazepine class are widely studied for their effects on the central nervous system. This particular compound has intriguing modifications that could potentially enhance its therapeutic profile.
  • Structural Features: The presence of both a chloro and a fluoro substituent offers unique properties, as halogens can significantly influence the compound's activity and binding affinity at receptors.
  • Potential Applications: Research is ongoing into the anxiety-relieving properties and possible neuroprotective effects of derivatives such as this one. The hydroxy group adds to the compound's complexity and might play a role in its biological interactions.
  • Synthetic Routes: The synthesis of such complex structures often involves multi-step processes, showcasing the innovation of synthetic organic chemistry. Scientists consistently seek efficient pathways to improve yield and reduce costs.

The study of benzodiazepines like 7-chloro-5-(2-fluorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one raises fascinating questions about structure-activity relationships (SAR) and how minor structural changes can lead to significant variations in pharmacological effects. As a scientist, understanding these relationships is crucial for developing more effective drugs with fewer side effects.

In conclusion, this compound is a prime example of how synthetic chemistry intersects with pharmacology, demonstrating the importance of chemical innovation in developing next-generation therapies.

Synonyms
17617-60-6
HDOQ
OX 164F
7-chloro-5-(2-fluorophenyl)-1,3-dihydro-3-hydroxy-2h-1,4-benzodiazepin-2-one
Ro 7-5205
2H-1,4-BENZODIAZEPIN-2-ONE, 1,3-DIHYDRO-7-CHLORO-5-(o-FLUOROPHENYL)-3-HYDROXY-
CM 40095
2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-3-hydroxy-
7-chloro-5-(2-fluorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one
1,3-Dihydro-7-chloro-5-(o-fluorophenyl)-3-hydroxy-2H-1,4-benzodiazepin-2-one
2H-1,4-Benzodiazepin-2-one,7-chloro-5-(2-fluorophenyl)-1,3-dihydro-3-hydroxy-
7-Chloro-5-(2-fluorophenyl)-3-hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one
BRN 0759083
3-Hydroxy desalkylflurazepam
CHEMBL64755
orb2814687
SCHEMBL7329203
DTXSID50874637
2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(o-fluorophenyl)-1,3-dihydro-3-hydroxy-
PD213398
HY-171028
AA-504/34481048
7-CL-1,3-H2-3-OH-5(2-FLPH)-1,4-DIAZEPIN-2-ONE
3-hydroxy-1,3-dihydro-7-chloro-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-one