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Clobazam

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Identification
Molecular formula
C16H13ClN2O2
CAS number
22316-47-8
IUPAC name
7-chloro-5-ethoxy-1-methyl-3H-1,4-benzodiazepin-2-one
State
State

At room temperature, Clobazam is in a solid state. It is stable under normal conditions and should be stored in a dry place at room temperature to maintain its crystalline integrity.

Melting point (Celsius)
178.00
Melting point (Kelvin)
451.15
Boiling point (Celsius)
542.80
Boiling point (Kelvin)
815.95
General information
Molecular weight
300.74g/mol
Molar mass
300.7510g/mol
Density
1.2890g/cm3
Appearence

Clobazam typically appears as a white to light yellow crystalline powder. It is odorless and has a slightly bitter taste. The compound can be visually identified by its crystalline form and coloration, which is consistent with many other benzodiazepines.

Comment on solubility

Solubility of 7-chloro-5-ethoxy-1-methyl-3H-1,4-benzodiazepin-2-one

The solubility of 7-chloro-5-ethoxy-1-methyl-3H-1,4-benzodiazepin-2-one can be described as follows:

  • Polar solvents: This compound exhibits moderate solubility in polar solvents such as methanol and ethanol.
  • Non-polar solvents: Its solubility tends to decrease in non-polar solvents, thus indicating a preference for polar environments.
  • Water solubility: The solubility in water is limited, which could be attributed to the overall hydrophobic character of the benzodiazepine structure.

Factors affecting the solubility include:

  • Molecular structure: The presence of chlorine and ethoxy groups influences hydrogen bonding and dipole interactions with the solvent.
  • Temperature: Increasing temperature often enhances solubility, leading to better dissolution in suitable solvents.
  • pH levels: The ionization state at different pH levels can also significantly impact solubility.

The variability in solubility underscores the importance of solvent selection for applications involving 7-chloro-5-ethoxy-1-methyl-3H-1,4-benzodiazepin-2-one.

In conclusion, understanding this compound's solubility characteristics is crucial for effective formulation and utilization in various chemical processes.

Interesting facts

Interesting Facts about 7-chloro-5-ethoxy-1-methyl-3H-1,4-benzodiazepin-2-one

7-chloro-5-ethoxy-1-methyl-3H-1,4-benzodiazepin-2-one belongs to the benzodiazepine class of compounds, which are widely recognized for their ability to modulate neurotransmitter activity in the brain. This compound, like others in its class, is known for its potential therapeutic applications and unique chemical structure.

Key Features:

  • Benzodiazepine Structure: The presence of a benzene ring fused to a diazepine moiety is characteristic of benzodiazepines, contributing to their biological activity.
  • Chlorine Atom: The chlorine substituent at position 7 significantly influences the compound’s pharmacological properties, enhancing its efficacy in certain therapeutic scenarios.
  • Ethoxy Group: The ethoxy substituent at position 5 may aid in increasing lipophilicity, potentially affecting absorption and metabolism.
  • Medical Usage: Compounds in this classification are commonly utilized in managing anxiety, insomnia, and other related disorders, showcasing their importance in psychopharmacology.

The synthesis of this compound typically involves established methods for creating benzodiazepine derivatives, utilizing reagents and conditions that promote controlled reactivity. Researchers continue to investigate the diverse effects and potential applications of 7-chloro-5-ethoxy-1-methyl-3H-1,4-benzodiazepin-2-one within various therapeutic frameworks.

As one might consider its therapeutic potential, it is essential to be aware of the risks associated with benzodiazepines, such as dependency and withdrawal symptoms. Hence, the exploration of compounds like this one often incorporates efforts to balance efficacy with safety.

Overall, the study of 7-chloro-5-ethoxy-1-methyl-3H-1,4-benzodiazepin-2-one not only illustrates the complexities of medicinal chemistry but also emphasizes the continuous evolution of drug development aimed at improving patient outcomes.

Synonyms
20430-79-9
BRN 0752180
3H-1,4-BENZODIAZEPIN-2(1H)-ONE, 7-CHLORO-5-ETHOXY-1-METHYL-
7-Chloro-5-ethoxy-1-methyl-3H-1,4-benzodiazepin-2(1H)-one
DTXSID60174377
CHEMBL3277010
DTXCID9096868
DB-307331
7-Chloro-5-ethoxy-1-methyl -1h-1,4-benzodiazepin-2(3h)-one