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Diazepam

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Identification
Molecular formula
C16H13ClN2O1
CAS number
439-14-5
IUPAC name
7-chloro-5-ethoxy-1-phenyl-3H-1,4-benzodiazepin-2-one
State
State

At room temperature, diazepam is typically encountered as a solid. It can sometimes be found in tablet form as well for pharmaceutical uses.

Melting point (Celsius)
131.00
Melting point (Kelvin)
404.00
Boiling point (Celsius)
309.80
Boiling point (Kelvin)
582.95
General information
Molecular weight
284.75g/mol
Molar mass
284.7440g/mol
Density
1.3000g/cm3
Appearence

Diazepam typically appears as a white to light yellow crystalline powder. It is odorless and has a slightly bitter taste.

Comment on solubility

Solubility of 7-chloro-5-ethoxy-1-phenyl-3H-1,4-benzodiazepin-2-one

The solubility of 7-chloro-5-ethoxy-1-phenyl-3H-1,4-benzodiazepin-2-one is an intriguing subject due to its unique structural components. Generally, the solubility of a compound is influenced by several factors, particularly its polarity and the presence of functional groups. Here are some notable points regarding this compound's solubility:

  • Polarity: The presence of the chloro and ethoxy groups can significantly affect the polarity of the compound, leading to variable solubility in different solvents.
  • Solvent Interaction: Many benzodiazepines exhibit moderate solubility in organic solvents like ethanol and chloroform, while showing low solubility in water.
  • pH Dependence: The solubility may increase in acidic or basic conditions due to potential ionization of the compound.
  • Temperature Effects: Solubility can also change with temperature; generally, an increase in temperature results in better solubility for many organic compounds.

In conclusion, while specific solubility data for 7-chloro-5-ethoxy-1-phenyl-3H-1,4-benzodiazepin-2-one may not be readily available, understanding the properties of similar compounds suggests that its solubility is likely influenced by a combination of its chemical structure and the nature of the solvent utilized. As is often said in chemistry, "like dissolves like", so anticipating its solubility behavior requires a careful look at its molecular characteristics.

Interesting facts

Interesting Facts about 7-Chloro-5-ethoxy-1-phenyl-3H-1,4-benzodiazepin-2-one

7-Chloro-5-ethoxy-1-phenyl-3H-1,4-benzodiazepin-2-one is a fascinating compound belonging to the benzodiazepine class, recognized for its distinctive chemical structure and pharmacological properties. Here are some intriguing aspects to consider:

  • Benzodiazepine Family: This compound is part of a larger family known for their sedative, anxiolytic, muscle relaxant, and anticonvulsant effects. Benzodiazepines alter the effect of a neurotransmitter called gamma-aminobutyric acid (GABA), leading to enhanced calmness and relaxation.
  • Chlorine Substituent: The presence of chlorine in its structure significantly influences the compound's activity and potency, showcasing how small modifications can lead to substantial changes in biochemical interactions.
  • Ethoxy Group: The ethoxy group also plays a vital role in determining the lipophilicity of the compound, which impacts its ability to penetrate cellular membranes and interact with biological targets.
  • Potential Applications: Compounds similar to this one are often explored for various medical applications, including their potential use in treating anxiety disorders, insomnia, and seizure disorders.
  • Research Scope: Ongoing studies into the effects and mechanisms of benzodiazepines contribute to our understanding of the central nervous system and can lead to the development of safer and more effective therapeutic alternatives.

In summary, 7-chloro-5-ethoxy-1-phenyl-3H-1,4-benzodiazepin-2-one represents a combination of intricate chemical design and significant therapeutic potential, making it a compelling subject of study in the field of medicinal chemistry. As stated in many scientific inquiries, "The details matter in drug design," unearthing how even slight changes can lead to innovative therapeutic solutions.

Synonyms
20430-81-3
BRN 0756391
3H-1,4-BENZODIAZEPIN-2(1H)-ONE, 7-CHLORO-5-ETHOXY-1-PHENYL-
7-Chloro-5-ethoxy-1-phenyl-3H-1,4-benzodiazepin-2(1H)-one
DTXSID80174379
CHEMBL3277022
DTXCID3096870
7-Chloro-5-ethoxy-1-phenyl-1H-1,4-benzodiazepin-2(3H)-one
DB-307332
7-Chloro-5-ethoxy-1-phenyl -1h-1,4-benzodiazepin-2(3h)-one