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Diazepam

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Identification
Molecular formula
C16H13ClN2O
CAS number
439-14-5
IUPAC name
7-chloro-5-phenyl-1-[2-(1-piperidyl)ethyl]-3H-1,4-benzodiazepin-2-one
State
State

Diazepam is a solid at room temperature. Typically, it is used in its crystalline powder form for pharmacological purposes.

Melting point (Celsius)
131.00
Melting point (Kelvin)
404.15
Boiling point (Celsius)
383.90
Boiling point (Kelvin)
657.05
General information
Molecular weight
284.74g/mol
Molar mass
284.7430g/mol
Density
1.4260g/cm3
Appearence

Diazepam occurs as a white or almost white crystalline powder. It is odorless or almost odorless and exhibits some form of hygroscopic properties. The crystalline powder form can be finely divided and is often used in its crystal form for pharmaceutical applications.

Comment on solubility

Solubility of 7-chloro-5-phenyl-1-[2-(1-piperidyl)ethyl]-3H-1,4-benzodiazepin-2-one

The solubility characteristics of 7-chloro-5-phenyl-1-[2-(1-piperidyl)ethyl]-3H-1,4-benzodiazepin-2-one are crucial for its application and effectiveness in various domains, particularly in medicinal chemistry. While specific solubility data may not always be readily available, several general observations can be made regarding compounds within the benzodiazepine class:

  • Polar vs. Nonpolar Solubility: Compounds like benzodiazepines typically exhibit varying degrees of solubility in polar and nonpolar solvents. This compound is likely to be soluble in organic solvents while having limited solubility in water.
  • Effect of Substituents: The presence of halogens (like chlorine in this case) and additional functional groups can enhance or hinder solubility. For example, the Cl atom may increase lipophilicity, affecting aqueous solubility.
  • pH Dependency: Solubility can often be pH-dependent. Changes in environmental pH can affect ionization states and solubility levels, especially for compounds that can accept or donate protons.

Determining the solubility of this compound in practical scenarios often necessitates empirical testing. In summary, although broad principles guide expectations around solubility, specifics can be quite compound-dependent. To closely evaluate solubility,
laboratory experiments and assays are essential for gaining accurate insights.

Interesting facts

Interesting Facts about 7-chloro-5-phenyl-1-[2-(1-piperidyl)ethyl]-3H-1,4-benzodiazepin-2-one

The compound 7-chloro-5-phenyl-1-[2-(1-piperidyl)ethyl]-3H-1,4-benzodiazepin-2-one belongs to the *benzodiazepine* class of drugs, which are widely recognized for their sedative and anxiolytic properties. This compound showcases some remarkable characteristics:

  • Mechanism of Action: Benzodiazepines primarily function by enhancing the effect of the neurotransmitter gamma-aminobutyric acid (GABA) in the brain, providing a calming effect for individuals experiencing anxiety or sleep disorders.
  • Structural Complexity: The presence of both a piperidine moiety and a phenyl group in its structure adds to its pharmacological diversity, implying that it may exhibit unique interactions within biological systems.
  • Therapeutic Applications: Compounds of this nature are often used in treating conditions such as anxiety, insomnia, seizures, and muscle spasms. Research into their efficacy continues to evolve, offering potential for new therapeutic uses.
  • Side Effects: While often effective, benzodiazepines can lead to side effects such as drowsiness, cognitive impairment, and dependency if used inappropriately.

Furthermore, the research into benzodiazepines has been *extensive*, with investigations into their *chemical properties*, *safety profiles*, and *long-term effects* on mental health. As noted by researchers, “Understanding the nuances of these compounds is vital for developing safe and effective treatments.” This underscores the importance of ongoing studies in pharmacology to improve patient outcomes while mitigating risks.

In summary, 7-chloro-5-phenyl-1-[2-(1-piperidyl)ethyl]-3H-1,4-benzodiazepin-2-one stands as an example within the broader context of *modern medicinal chemistry*, highlighting the balance between efficacy and safety in drug development.