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Diazepam

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Identification
Molecular formula
C16H13ClN2O
CAS number
439-14-5
IUPAC name
7-chloro-5-phenyl-1-(2-piperazin-1-ylethyl)-3H-1,4-benzodiazepin-2-one
State
State

At room temperature, diazepam is generally in a solid crystalline state used in tablets. It can also be found in a liquid solution for intravenous use.

Melting point (Celsius)
131.00
Melting point (Kelvin)
404.15
Boiling point (Celsius)
309.90
Boiling point (Kelvin)
583.05
General information
Molecular weight
284.74g/mol
Molar mass
284.7380g/mol
Density
1.3003g/cm3
Appearence

Diazepam is a colorless to light yellow crystal, often found in powder form for pharmaceutical formulations. It can also be available in solution form, which appears as a clear, colorless to pale yellow liquid.

Comment on solubility

Solubility of 7-chloro-5-phenyl-1-(2-piperazin-1-ylethyl)-3H-1,4-benzodiazepin-2-one

The solubility of the compound 7-chloro-5-phenyl-1-(2-piperazin-1-ylethyl)-3H-1,4-benzodiazepin-2-one can be quite interesting due to its unique structure. Here are some key points to consider:

  • Polar vs. Non-Polar: This compound contains both polar (chlorine and piperazine group) and non-polar (phenyl and benzodiazepine structures) components, which can lead to variable solubility in different solvents.
  • Aqueous Solubility: It is likely to have moderate to low solubility in water, primarily due to the bulky phenyl and benzodiazepine ring that limits interaction with water molecules.
  • Organic Solvents: It may show better solubility in organic solvents such as ethanol or DMSO, where non-polar interactions can be more favorable.
  • Influence of pH: The solubility could be significantly affected by the pH of the solution, as the piperazine group can be protonated.

In summary, the solubility of 7-chloro-5-phenyl-1-(2-piperazin-1-ylethyl)-3H-1,4-benzodiazepin-2-one exhibits complexity due to its dual nature. As stated, "the structure dictates solubility," making it essential to consider the solvent and conditions when predicting its behavior in solution.

Interesting facts

Interesting Facts about 7-Chloro-5-phenyl-1-(2-piperazin-1-ylethyl)-3H-1,4-benzodiazepin-2-one

7-Chloro-5-phenyl-1-(2-piperazin-1-ylethyl)-3H-1,4-benzodiazepin-2-one is a member of the benzodiazepine class, widely recognized for their **therapeutic applications**. Here are some noteworthy points about this intriguing compound:

  • Pharmacological significance: Benzodiazepines, including this compound, are primarily used for their **anxiolytic**, **sedative**, and **muscle relaxant** properties. They interact with the central nervous system, promoting relaxation and reducing anxiety.
  • Mechanism of action: This compound acts on the **GABAA receptor**, enhancing the inhibitory effects of the neurotransmitter GABA. This promotes a calming effect on the brain and can be beneficial in treating conditions such as anxiety and insomnia.
  • Research opportunities: The unique piperazine moiety in its structure allows for modification and exploration in the development of new **therapeutic agents**. Scientists continue to investigate derivatives of benzodiazepines for improved efficacy and reduced side effects.
  • Historical context: The discovery of benzodiazepines dates back to the mid-20th century, revolutionizing the treatment landscape for mental health disorders. Compounds like this one mark a significant milestone in pharmacology.
  • Challenges and considerations: While benzodiazepines are effective, they also pose risks of **dependence** and **withdrawal symptoms**. Researching ways to mitigate these risks while maintaining therapeutic efficacy is a focus in the field of medicinal chemistry.
  • Structural diversity: The presence of the chloro and phenyl groups in the structure contributes to its biological activity, opening avenues for designing **specific analogs** that might offer enhanced or selective pharmacological properties.

In summary, 7-Chloro-5-phenyl-1-(2-piperazin-1-ylethyl)-3H-1,4-benzodiazepin-2-one serves as a vital link in understanding the interactions and potential clinical applications of benzodiazepines, emphasizing the continuous need for research in this significant field of chemistry.