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Diazepam

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Identification
Molecular formula
C16H13ClN2O
CAS number
439-14-5
IUPAC name
7-chloro-5-phenyl-1-(2-pyrrolidin-1-ylethyl)-3H-1,4-benzodiazepin-2-one
State
State

Diazepam is found in a solid, crystalline state at room temperature. It is commonly available in tablet or crystal form for medical use.

Melting point (Celsius)
131.00
Melting point (Kelvin)
404.15
Boiling point (Celsius)
275.60
Boiling point (Kelvin)
548.75
General information
Molecular weight
284.71g/mol
Molar mass
284.7050g/mol
Density
1.3200g/cm3
Appearence

Diazepam is typically a white to yellow crystalline powder. It is odorless or may have a faint characteristic odor.

Comment on solubility

Solubility of 7-chloro-5-phenyl-1-(2-pyrrolidin-1-ylethyl)-3H-1,4-benzodiazepin-2-one

The solubility of 7-chloro-5-phenyl-1-(2-pyrrolidin-1-ylethyl)-3H-1,4-benzodiazepin-2-one can significantly influence its behavior in various formulations and biological systems. Understanding its solubility properties is essential for assessing its therapeutic potential and application.

Factors Affecting Solubility

Several factors can affect the solubility of this compound:

  • Polarity: The presence of polar functional groups in the molecule can lead to increased solubility in polar solvents.
  • pH: The solubility may vary with changes in pH, particularly if the compound has acidic or basic sites that ionize.
  • Temperature: Generally, solubility increases with temperature for most organic compounds.
  • Solvent type: Solubility is highly dependent on the solvent used; hence, a non-polar solvent may not dissolve the compound effectively.

General Observations

While specific solubility data for this compound might not be readily available, it is often observed that:

  • **Organic compounds like this are more soluble in organic solvents** such as ethanol, dimethyl sulfoxide (DMSO), or methanol than in water.
  • The lipophilicity of the benzodiazepine structure suggests potential for moderate solubility in lipid-based solvents.

In conclusion, understanding the solubility of this compound is critical, as it affects its absorption, distribution, and overall pharmacological activity. Engaging in experimental solubility determinations may yield valuable insights for its practical applications.

Interesting facts

Interesting Facts about 7-chloro-5-phenyl-1-(2-pyrrolidin-1-ylethyl)-3H-1,4-benzodiazepin-2-one

This compound belongs to the benzodiazepine class, a group of medications known for their anxiolytic, sedative, and hypnotic properties. Benzodiazepines often target the GABAA receptor in the brain, leading to increased inhibitory neurotransmission. Here are some fascinating details about this compound:

  • Clinical Uses: While the specific clinical application of this compound may vary, derivatives of benzodiazepines are widely used to treat anxiety, insomnia, and muscle spasticity.
  • Molecular Modifications: The presence of the pyrrolidine ring may enhance its pharmacological properties compared to traditional benzodiazepines, making it a subject of interest in medicinal chemistry.
  • Research Potential: Compounds like this one are often studied for their potential in developing safer and more effective therapies, particularly for patients with anxiety disorders who may not respond well to conventional treatments.
  • Structure-Activity Relationship (SAR): The modification of phenyl and chloro groups in its structure illustrates the importance of SAR in designing compounds that provide desired therapeutic effects with fewer side effects.

As researchers continue to explore the vast landscape of benzodiazepines, compounds like 7-chloro-5-phenyl-1-(2-pyrrolidin-1-ylethyl)-3H-1,4-benzodiazepin-2-one serve as vital links between chemical structure and biological activity.

Ultimately, understanding such complex molecules not only enhances our knowledge of pharmacology but also paves the way for innovative therapeutic strategies in neuropharmacology.