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Clonazepam

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Identification
Molecular formula
C15H10ClFN2O
CAS number
1622-62-4
IUPAC name
7-chloro-5-phenyl-1-(2,2,2-trifluoroethyl)-3H-1,4-benzodiazepin-2-one
State
State

At room temperature, clonazepam is typically found as a crystalline solid. It is not normally encountered as a liquid or gas under standard conditions.

Melting point (Celsius)
239.00
Melting point (Kelvin)
512.00
Boiling point (Celsius)
457.40
Boiling point (Kelvin)
730.50
General information
Molecular weight
315.72g/mol
Molar mass
315.7200g/mol
Density
1.8927g/cm3
Appearence

Clonazepam appears as a white to light yellow crystalline powder, although it can also be obtained as off-white crystals. It is typically supplied in a tablet form for medical applications.

Comment on solubility

Solubility Insights for 7-chloro-5-phenyl-1-(2,2,2-trifluoroethyl)-3H-1,4-benzodiazepin-2-one

The solubility of the compound 7-chloro-5-phenyl-1-(2,2,2-trifluoroethyl)-3H-1,4-benzodiazepin-2-one can be intriguing due to its unique structural features. Understanding its solubility characteristics is essential for various applications, including pharmaceutical formulations and chemical reactions.

Key Factors Influencing Solubility:

  • Polarity: The presence of the trifluoroethyl group increases the polarity of the compound, which may enhance solubility in polar solvents, such as water or ethanol.
  • Hydrogen Bonding: The nitrogen and carbonyl functional groups can participate in hydrogen bonding, potentially increasing solubility in solvents that can form similar interactions.
  • Size and Steric Effects: The bulky phenyl group can hinder solubility in some cases, as larger structures may encounter steric hindrance with solvent molecules.

Overall, it’s anticipated that this compound will exhibit moderate to low solubility in aqueous solutions while possibly being more soluble in organic solvents. This dual behavior can be crucial in drug design, making it essential for scientists to perform comprehensive solubility assays to determine optimal conditions for use.

In summary, exploring the solubility of 7-chloro-5-phenyl-1-(2,2,2-trifluoroethyl)-3H-1,4-benzodiazepin-2-one requires a careful balancing of its molecular characteristics, solvent properties, and environmental factors.

Interesting facts

Interesting Facts about 7-Chloro-5-phenyl-1-(2,2,2-trifluoroethyl)-3H-1,4-benzodiazepin-2-one

This compound is a member of the benzodiazepine family, which are widely recognized for their therapeutic effects. Here are some intriguing insights into this particular benzodiazepine:

  • Therapeutic Uses: Compounds like this one have been explored for their anxiolytic, sedative, and muscle-relaxing properties. They are often prescribed to manage anxiety disorders and sleep disturbances.
  • Structure-Activity Relationship: The specific functional groups present in this compound, such as the chloro and trifluoroethyl groups, can significantly influence its biological activity and pharmacokinetics, making it a point of interest for medicinal chemists.
  • Synthetic Pathways: The synthesis of such compounds can involve complex reactions, including nucleophilic substitutions and cyclization processes, offering rich grounds for research in organic chemistry.
  • Research Potential: Due to its unique structure, compounds like this one hold potential for new drug development, particularly in enhancing efficacy while minimizing side effects traditionally associated with benzodiazepines.
  • Fluorine in Drug Design: The incorporation of fluorine atoms often improves the metabolic stability of pharmaceutical compounds, making this trifluoroethyl group particularly valuable in drug design.

The exploration of benzodiazepines remains an active and dynamic area in pharmacology, reflecting ongoing advancements and challenges in developing safe, effective therapeutic agents. As such, studying compounds like 7-chloro-5-phenyl-1-(2,2,2-trifluoroethyl)-3H-1,4-benzodiazepin-2-one not only contributes to our understanding of medicinal chemistry but also highlights the intricate relationship between chemical structure and biological function.

In the words of Dr. Emile Zola, “If you ask me what I came into this life to do, I will tell you: I came to live out loud.” Such is the message of chemical research—a commitment to unravel the mysteries of compounds that can profoundly impact human health.

Synonyms
Halazepam
Paxipam
Pacinone
23092-17-3
Sch 12041
Halazepamum
Sch-12041
Halazepam civ
Alapryl
7-Chloro-1,3-dihydro-5-phenyl-1-(2,2,2-trifluoroethyl)-2H-1,4-benzodiazepin-2-one
2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-5-phenyl-1-(2,2,2-trifluoroethyl)-
320YC168LF
DTXSID5023118
7-chloro-5-phenyl-1-(2,2,2-trifluoroethyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one
alazepam
RefChem:58717
DTXCID003118
N05BA13
245-425-4
Halazepamum [INN-Latin]
Schering 12041
7-chloro-5-phenyl-1-(2,2,2-trifluoroethyl)-3H-1,4-benzodiazepin-2-one
7-Chloro-5-phenyl-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-phenyl-1-(2,2,2-trifluoroethyl)-
Halazepam (1.0mg/ml in Acetonitrile)
Paxipam (TN)
Halazepam (USAN/INN)
EINECS 245-425-4
BRN 0898553
Halezepam
UNII-320YC168LF
DEA No. 2762
Halazepam [USAN:USP:INN:BAN]
HALAZEPAM [INN]
HALAZEPAM [MI]
HALAZEPAM [USAN]
HALAZEPAM [VANDF]
CHEMBL970
HALAZEPAM [MART.]
HALAZEPAM [WHO-DD]
SCHEMBL78995
5-24-04-00303 (Beilstein Handbook Reference)
CHEBI:5603
GTPL7195
HALAZEPAM [ORANGE BOOK]
SCHEMBL29375979
BDBM50408018
DB00801
NS00007779
D00338
Q5641126
7-Chloro-5-phenyl-1-(2,2,2-trifluorethyl)-1H-1,4-benzodiazepin-2(3H)-on