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Clonazepam

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Identification
Molecular formula
C15H10ClN3O2
CAS number
1622-61-3
IUPAC name
7-chloro-5-phenyl-1,3,4,5-tetrahydro-1,4-benzodiazepin-2-one
State
State

At room temperature, clonazepam is in a solid state. It is commonly found in the form of oral tablets for medicinal use.

Melting point (Celsius)
239.00
Melting point (Kelvin)
512.00
Boiling point (Celsius)
410.60
Boiling point (Kelvin)
683.80
General information
Molecular weight
315.72g/mol
Molar mass
315.7150g/mol
Density
1.4270g/cm3
Appearence

Clonazepam typically appears as a white to light yellow powder. It is odorless and has a crystalline structure. It is often pressed into tablets for pharmaceutical use.

Comment on solubility

Solubility of 7-chloro-5-phenyl-1,3,4,5-tetrahydro-1,4-benzodiazepin-2-one

The solubility of the compound 7-chloro-5-phenyl-1,3,4,5-tetrahydro-1,4-benzodiazepin-2-one can be influenced by various factors, including solvent choice, temperature, and molecular interactions. Notably, this compound belongs to the class of benzodiazepines, which typically present certain solubility characteristics:

  • Polar Solvents: The presence of polar functional groups may enhance solubility in polar solvents like water, but overall, benzodiazepines often exhibit limited solubility in water.
  • Organic Solvents: Compounds in this class usually dissolve well in organic solvents such as ethanol or dimethyl sulfoxide (DMSO), which can solvate the hydrophobic regions effectively.
  • Temperature Influence: Increasing temperature can increase the solubility of many organic compounds, including benzodiazepines, allowing for better dissolution in solvents.

In summary, while 7-chloro-5-phenyl-1,3,4,5-tetrahydro-1,4-benzodiazepin-2-one may exhibit limited solubility in water, its interaction with organic solvents could provide a more favorable outcome. Thus, understanding the specific solubility behavior and optimal conditions is essential for practical applications.

Interesting facts

Interesting Facts about 7-chloro-5-phenyl-1,3,4,5-tetrahydro-1,4-benzodiazepin-2-one

This compound belongs to the benzodiazepine class, which is well-known for its applications in medicine, particularly as anxiolytics, sedatives, and anticonvulsants. Here are some captivating aspects of this chemical:

  • Structural Significance: The unique structure of this compound incorporates a chloro group and a phenyl ring, which contribute to its biological activity.
  • Therapeutic Applications: Compounds in the benzodiazepine family are often employed in treating anxiety disorders, insomnia, and muscle tension.
  • Mechanism of Action: These compounds enhance the effect of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABAA receptor, resulting in sedative and anxiolytic effects.
  • Research Interest: Due to its structural characteristics, this compound serves as a vital point of interest for researchers aiming to develop new drugs with improved efficacy and fewer side effects.
  • Potential for Modification: The presence of functional groups like the chloro and phenyl allows for various synthetic modifications, which can lead to derivatives with diverse pharmacological properties.

Overall, 7-chloro-5-phenyl-1,3,4,5-tetrahydro-1,4-benzodiazepin-2-one serves as an excellent example of how a specific molecular structure influences biological activity and therapeutic potential, making it a subject of ongoing scientific exploration and interest.

Synonyms
1824-69-7
1-Demethyl-4,5-dihydrodiazepam
7-Chloro-1,3,4,5-tetrahydro-5-phenyl-2H-1,4-benzodiazepin-2-one
NSC 46079
UNII-BI385574RG
BRN 0753609
BI385574RG
NSC-46079
1,3,4,5-Tetrahydro-7-chloro-5-phenyl-2H-1,4-benzodiazepin-2-one
2H-1,4-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-7-chloro-5-phenyl-
2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3,4,5-tetrahydro-5-phenyl-
5-24-04-00149 (Beilstein Handbook Reference)
2H-1,4-BENZODIAZEPIN-2-ONE, 7-CHLORO-5-PHENYL-1,3,4,5-TETRAHYDRO-
7-chloro-5-phenyl-2,3,4,5-tetrahydro-1h-1,4-benzodiazepin-2-one
7-CHLORO-2-OXO-5-PHENYL-1,2,4,5-TETRAHYDRO-3H-1,4-BENZODIAZEPINE
7-CHLORO-4,5-DIHYDRO-5-PHENYL-1H-BENZO(E)(1,4)DIAZEPIN-2(3H)-ONE
7-CHLORO-4,5-DIHYDRO-5-PHENYL-3H-1,4-BENZODIAZEPIN-2(1H)-ONE
7-CHLORO-5-PHENYL-1,2,3,4-TETRAHYDRO-5H-1,4-BENZODIAZEPIN-2-ONE
2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3,4,5-tetrahydro-5-phenyl-(8CI)
2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3,4,5-tetrahydro-5-phenyl-(8CI)(9CI)
7-chloro-5-phenyl-1,3,4,5-tetrahydro-1,4-benzodiazepin-2-one
Ro 5-2181
GYQOYYFIHYKFEO-UHFFFAOYSA-N
NSC46079
SCHEMBL1421019
DTXSID101306474
STL037898
STL282776
WLN: T67 GMV JM&TJ CG KR
AKOS001209288
AKOS005691523
AKOS016400822
AB00980566-01
2H-1, 7-chloro-1,3,4,5-tetrahydro-5-phenyl-
2H-1, 7-chloro-5-phenyl-1,3,4,5-tetrahydro-
Q27274668
Z56891911
7-chloro-5-phenyl-4,5-dihydro-3H-1,4-benzodiazepin-2-ol
5-phenyl-7-chloro-1,3,4,5-tetrahydro-2H-1,4-benzodiazepine-2-one
7-Chloro-1,4,5-tetrahydro-5-phenyl-2H-1,4-benzodiazepin-2-one
7-chloro-5-phenyl-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one
7-chloro-5-phenyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one