Skip to main content

7-Chloro-5-phenyl-1,4-benzodiazepine

ADVERTISEMENT
Identification
Molecular formula
C16H13ClN2
CAS number
27443-44-3
IUPAC name
7-chloro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepine
State
State

This compound exists as a solid under standard room temperature and pressure conditions.

Melting point (Celsius)
161.50
Melting point (Kelvin)
434.65
Boiling point (Celsius)
355.50
Boiling point (Kelvin)
628.65
General information
Molecular weight
274.74g/mol
Molar mass
274.7330g/mol
Density
1.2400g/cm3
Appearence

7-Chloro-5-phenyl-1,4-benzodiazepine is typically a crystalline solid, often appearing as white to off-white crystals.

Comment on solubility

Solubility of 7-chloro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepine

The solubility of 7-chloro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepine exhibits specific characteristics influenced by its chemical structure. Understanding the solubility of this compound involves considering various factors:

  • Polarity: As a benzodiazepine derivative, this compound is likely to possess moderate polarity due to its chlorine and phenyl substituents. This affects its solubility in different solvents.
  • Solvent Compatibility: It may show better solubility in organic solvents such as DMSO (Dimethyl Sulfoxide) or ethanol rather than in polar solvents like water.
  • Temperature Dependence: Like many organic compounds, solubility can increase with temperature. Thus, heating the solvent may improve the dissolution rate.
  • Complex Formation: Interaction with solvents may lead to solvate formation, complicating the solubility dynamics.

In summary, while the solubility of 7-chloro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepine may not be extensively documented, it can be anticipated that its solubility will be higher in non-polar or low polarity solvents. This information could prove crucial for its application in various chemical contexts and research.

Interesting facts

Interesting Facts about 7-Chloro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepine

7-Chloro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepine is a fascinating compound that belongs to the class of benzodiazepines. These compounds are primarily known for their psychoactive properties and are widely utilized in pharmacology.

Key Highlights

  • Pharmacological Importance: Benzodiazepines are essential in the treatment of anxiety, insomnia, and seizures.
  • Mechanism of Action: This compound functions by enhancing the effect of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABAA receptor, leading to sedative and anxiolytic effects.
  • Structural Significance: The unique structure of 7-chloro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepine contributes to its biological activity, making it a compound of interest in medicinal chemistry.
  • Research Applications: This compound is often studied for its potential in developing new therapeutics that may have fewer side effects compared to traditional benzodiazepines.

"The discovery of benzodiazepines transformed the treatment landscape for anxiety and sleep disorders."

Future Directions

As research continues, scientists are exploring the possibility of designing novel benzodiazepine derivatives that retain efficacy but offer improved safety profiles. This compound serves as a valuable lead structure for such developments. The ongoing studies aim to elucidate the specific interactions at the molecular level, enhancing our understanding of benzodiazepine pharmacodynamics.

Overall, 7-chloro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepine reflects the complexity and potential of chemical compounds in shaping medicinal therapies, emphasizing the profound impact that structural chemistry has on pharmacological outcomes.

Synonyms
Desmethylmedazepam
1694-78-6
Ro 5-2925
BRN 0749048
N-Desmethyl-medazepam
1H-1,4-BENZODIAZEPINE, 7-CHLORO-2,3-DIHYDRO-5-PHENYL
DTXSID90168709
5-23-09-00035 (Beilstein Handbook Reference)
DTXCID7091200
jzwokdtxypejew-uhfffaoysa-n
7-Chloro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepine
Normedazepam
7-chloro-2,3-dihydro-5-phenyl-1H-1,4-benzodiazepine
7-Chloro-2,3-dihydro-5-phenyl-1H-1,4-benzodiazepine; 7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepine; 7-Chloro-5-phenyl-1,2-dihydro-3H-1,4-benzodiazepine; Desmethylmedazepam; N-Desmethylmedazepam; Ro 5-2925
SCHEMBL11460470
BAA69478
7-chloro-5-phenyl-2,3-dihydro-1H-[1,4]benzodiazepine
7-Chloro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepine #