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7-Chloro-5-phenyl-3H-1,4-benzodiazepine

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Identification
Molecular formula
C15H10ClN2
CAS number
15793-39-8
IUPAC name
7-chloro-5-phenyl-3H-1,4-benzodiazepine
State
State

At room temperature, 7-chloro-5-phenyl-3H-1,4-benzodiazepine is typically found as a solid.

Melting point (Celsius)
154.00
Melting point (Kelvin)
427.15
Boiling point (Celsius)
404.00
Boiling point (Kelvin)
677.15
General information
Molecular weight
267.71g/mol
Molar mass
267.7210g/mol
Density
1.2190g/cm3
Appearence

7-Chloro-5-phenyl-3H-1,4-benzodiazepine is a white to off-white crystalline powder.

Comment on solubility

Solubility of 7-chloro-5-phenyl-3H-1,4-benzodiazepine

The solubility of 7-chloro-5-phenyl-3H-1,4-benzodiazepine can be described through several key factors:

  • Polarity: This compound typically exhibits low polarity, which often results in poor solubility in polar solvents, such as water.
  • Solvent Compatibility: It is more likely to be soluble in organic solvents such as ethanol, chloroform, and DMSO due to its hydrophobic characteristics.
  • Temperature Dependence: Generally, solubility can be enhanced with increased temperature, allowing for better dissolution in suitable organic solvents.
  • pH Influence: Changes in pH can affect the ionization of the compound, thereby influencing its solubility in different environments.

In summary, while 7-chloro-5-phenyl-3H-1,4-benzodiazepine showcases limited solubility in aqueous solutions, it demonstrates a stronger affinity for various organic solvents, making it crucial to select appropriate solvents in experimental applications. Thus, it's essential to consider these parameters when working with this compound in laboratory settings.

Interesting facts

Interesting Facts about 7-Chloro-5-phenyl-3H-1,4-benzodiazepine

7-Chloro-5-phenyl-3H-1,4-benzodiazepine is a fascinating compound within the benzodiazepine family, which is known for its significant impact in the field of pharmacology. This compound stands out due to its unique chemical structure and the valuable properties associated with it:

  • Pharmacological Effects: Benzodiazepines are widely recognized for their anxiolytic, sedative, and muscle relaxant properties. This particular compound is studied for its potential applications in managing anxiety disorders.
  • Chemical Structure: The incorporation of chlorine and phenyl groups in the structure of this compound enhances its binding affinity to the GABAA receptors, contributing to its effectiveness as a tranquilizer.
  • Research Tool: The unique structure of 7-chloro-5-phenyl-3H-1,4-benzodiazepine makes it a useful tool for researchers studying neuropharmacology and neurobiology, allowing for the observation of neurotransmitter interactions.
  • Public Health Considerations: While benzodiazepines are fundamental in treating various medical conditions, their use comes with concerns regarding dependency and withdrawal, making the study of specific compounds like this one essential for creating safer alternatives.
  • Potential for Novel Applications: Ongoing research into benzodiazepines continues to reveal new potential applications beyond traditional uses, such as in the treatment of insomnia and certain types of seizure disorders.

In essence, the exploration of 7-chloro-5-phenyl-3H-1,4-benzodiazepine helps bridge the gap between organic chemistry and therapeutic medicine, offering insight into how molecular modifications can lead to improved drugs. As a chemistry student or scientist, understanding such compounds is not only key to advancing pharmaceutical development but also contributes to a broader understanding of chemical interactions in biological systems.

Synonyms
16398-00-8
BRN 0747559
Ro 7-0220
3H-1,4-BENZODIAZEPINE, 7-CHLORO-5-PHENYL-
DTXSID60167688
5-23-09-00207 (Beilstein Handbook Reference)
DTXCID5090179
7-chloro-5-phenyl-3H-1,4-benzodiazepine
SCHEMBL11351339
GIVYEEPCHMGCEK-UHFFFAOYSA-N
7-Chlor-5-phenyl-3H-1,4-benzodiazepin