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Piperaquine

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Identification
Molecular formula
C29H32Cl2N6
CAS number
4085-31-8
IUPAC name
7-chloro-N-[2-[4-[2-[(7-chloro-4-quinolyl)amino]propyl]piperazin-1-yl]-1-methyl-ethyl]quinolin-4-amine
State
State

Piperaquine is in solid state at room temperature.

Melting point (Celsius)
180.00
Melting point (Kelvin)
453.15
Boiling point (Celsius)
655.60
Boiling point (Kelvin)
928.75
General information
Molecular weight
535.52g/mol
Molar mass
535.5000g/mol
Density
1.3200g/cm3
Appearence

Piperaquine is typically present as a white or almost white crystalline powder.

Comment on solubility

Solubility of 7-chloro-N-[2-[4-[2-[(7-chloro-4-quinolyl)amino]propyl]piperazin-1-yl]-1-methyl-ethyl]quinolin-4-amine

The solubility of 7-chloro-N-[2-[4-[2-[(7-chloro-4-quinolyl)amino]propyl]piperazin-1-yl]-1-methyl-ethyl]quinolin-4-amine can be quite intriguing due to its complex structure.

Factors influencing its solubility include:

  • Polarity: The presence of various functional groups may alter solubility in polar or nonpolar solvents.
  • Hydrogen Bonding: Capable of forming hydrogen bonds can enhance solubility in polar solvents.
  • Molecular Weight: Higher molecular weights typically reduce solubility in solvents.

It is important to note that this compound may exhibit:

  • Moderate to low solubility in aqueous solutions, primarily due to its bulky structure.
  • Better solubility in organic solvents like DMSO or ethanol.

As with many pharmaceutical compounds, solubility remains a critical factor influencing bioavailability. Hence, understanding its solubility characteristics is essential for dosage formulation and therapeutic efficacy.

In summary, the solubility of this compound is not a straightforward matter and must be evaluated in the context of its chemical structure and intended application.

Interesting facts

Interesting Facts about 7-Chloro-N-[2-[4-[2-[(7-chloro-4-quinolyl)amino]propyl]piperazin-1-yl]-1-methyl-ethyl]quinolin-4-amine

This compound belongs to a class of chemicals known as quinolines, which are known for their diverse biological activities. Here are some fascinating points about this particular compound:

  • Medicinal Applications: Due to its unique structure, it has been investigated for its potential use in treating various medical conditions, especially related to infectious diseases and cancer.
  • Complex Structure: Its intricate arrangement of functional groups allows it to interact with biological targets effectively, enhancing its therapeutic potential.
  • Quinoline Derivatives: As a derivative of quinoline, it bears similarity to many important drugs, suggesting that modifications to its structure could lead to new pharmaceutical developments.
  • Research Interest: Scientists focus on quinoline compounds because they can exhibit properties like anti-malarial and anti-cancer activities, making them valuable in drug discovery.
  • Importance in Chemistry: This compound exemplifies how small changes in chemical structure can significantly affect biological activity, highlighting the importance of structure-activity relationships in medicinal chemistry.

As quoted by one renowned chemist, "The beauty of chemistry lies in its complexity and the understanding that even the smallest alteration can lead to profound differences in function." This statement resonates well with the characteristics of 7-chloro-N-[2-[4-[2-[(7-chloro-4-quinolyl)amino]propyl]piperazin-1-yl]-1-methyl-ethyl]quinolin-4-amine.

In summary, the exploration of this compound not only contributes to the field of medicinal chemistry but also emphasizes the broad spectrum of possibilities that lie within chemical research.

Synonyms
10547-40-7
NSC129790
7-chloro-N-[1-[4-[2-[(7-chloroquinolin-4-yl)amino]propyl]piperazin-1-yl]propan-2-yl]quinolin-4-amine
NSC-129790
N,N'-bis-(7-Chloro-4-quinolyl)-alpha,alpha'-dimethylpiperazine-1,4-diethylamine
CHEMBL1987194
DTXSID70909556
WR-3863
NCI60_000671
RP-12278
1,4-BIS(2-(7-CHLORO-4-QUINOLYLAMINO)PROPYL)PIPERAZINE
BIS((CHLORO-7''-QUINOLYL-4'')AMINO-2'-PROPYL)-1,4-PIPERAZINE DICHLORQUINAZINE
N,N'-[Piperazine-1,4-diyldi(propane-1,2-diyl)]bis(7-chloroquinolin-4-amine)
1,4-PIPERAZINEDIETHANAMINE, N1,N4-BIS(7-CHLORO-4-QUINOLINYL)-.ALPHA.1,.ALPHA.4-DIMETHYL-
7-Chloro-N-(2-(4-(2-((7-chloro-4-quinolinyl)amino)propyl)-1-piperazinyl)-1-methylethyl)-4-quinolinamine
7-chloro-N-[2-[4-[2-[(7-chloro-4-quinolyl)amino]propyl]piperazin-1-yl]-1-methyl-ethyl]quinolin-4-amine
N-(7-Chloro-4-quinolinyl)-N-(2-(4-(2-((7-chloro-4-quinolinyl)amino)propyl)-1-piperazinyl)-1-methylethyl)amine