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Clonazepam

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Identification
Molecular formula
C15H10ClN3O2
CAS number
1622-61-3
IUPAC name
7-chloro-N-cyclopropyl-4-hydroxy-5-phenyl-3H-1,4-benzodiazepin-2-imine
State
State

At room temperature, clonazepam is a solid.

Melting point (Celsius)
239.00
Melting point (Kelvin)
512.00
Boiling point (Celsius)
352.70
Boiling point (Kelvin)
625.90
General information
Molecular weight
315.72g/mol
Molar mass
315.7150g/mol
Density
2.0040g/cm3
Appearence

Clonazepam typically appears as a white to light yellow crystalline powder. It is practically insoluble in water and sparingly soluble in ethanol.

Comment on solubility

Solubility Characteristics

The compound 7-chloro-N-cyclopropyl-4-hydroxy-5-phenyl-3H-1,4-benzodiazepin-2-imine exhibits interesting solubility properties that are worth exploring. Understanding its solubility can provide insights into its bioavailability and potential applications.

General Solubility Profile

When evaluating the solubility of this compound, it is important to consider the following factors:

  • Polarity: The presence of polar functional groups, such as the -OH (hydroxyl) group, often enhances solubility in polar solvents like water.
  • Hydrophobic Regions: The phenyl group and the cyclopropyl ring introduce hydrophobic characteristics, which can complicate solubility in aqueous environments.
  • Solvent Interaction: The solubility may vary significantly depending on the solvent used, with organic solvents likely providing better solubility due to the hydrophobic regions.

Specific Observations

It is often noted that:

  • The compound may show low solubility in water, in line with other benzodiazepine derivatives.
  • In contrast, it may dissolve well in non-polar organic solvents such as ethanol or dimethyl sulfoxide (DMSO).

Therefore, the overall solubility behavior can be summarized as being influenced by the delicate balance between hydrophilic and hydrophobic properties within its molecular structure.

Conclusion

In conclusion, understanding the solubility of 7-chloro-N-cyclopropyl-4-hydroxy-5-phenyl-3H-1,4-benzodiazepin-2-imine is crucial for its application in pharmaceuticals and related fields. As with many complex organic compounds, targeted studies and experiments are essential to fully characterize its solubility behavior.

Interesting facts

Interesting Facts About 7-Chloro-N-cyclopropyl-4-hydroxy-5-phenyl-3H-1,4-benzodiazepin-2-imine

This compound, part of the benzodiazepine family, features a complex structure that provides it with intriguing properties and potential applications. Here are some interesting aspects of this subclass of benzodiazepines:

  • Structure and Activity: The incorporation of a cyclopropyl group and chloro substitution significantly influences the pharmacological activity of the compound. These structural modifications can enhance binding affinity to specific receptors in the central nervous system.
  • Therapeutic Potential: Compounds of this class are often investigated for their anxiolytic, sedative, and anticonvulsant properties. The unique structure may offer new therapeutic avenues, particularly in managing anxiety disorders and epilepsy.
  • Research Interests: Due to their varied mechanisms of action, benzodiazepines like this compound continue to be a focus in medicinal chemistry. Scientists are exploring ways to develop derivatives that could lead to fewer side effects compared to traditional benzodiazepines.
  • Safety Concerns: While they can be highly effective, some benzodiazepines have been associated with dependency issues. This underscores the importance of ongoing research to create compounds that balance efficacy with safety.

As we delve deeper into the world of medicinal chemistry, the study of 7-chloro-N-cyclopropyl-4-hydroxy-5-phenyl-3H-1,4-benzodiazepin-2-imine and similar compounds is crucial in the quest for more effective and safer therapeutic agents. Understanding their mechanisms enables chemists to innovate new drugs that could transform patient care.

Synonyms
3H-1,4-BENZODIAZEPINE, 7-CHLORO-2-(CYCLOPROPYLAMINO)-5-PHENYL-, 4-OXIDE
3864-80-0
BRN 0690982
7-Chloro-2-(cyclopropylamino)-5-phenyl-3H-1,4-benzodiazepine-4-oxide