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7-Chloro-1,4-benzodiazepin-2-imine derivative

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Identification
Molecular formula
C19H17ClN2O
CAS number
946409-67-4
IUPAC name
7-chloro-N-(cyclopropylmethyl)-4-hydroxy-5-phenyl-3H-1,4-benzodiazepin-2-imine
State
State

Under standard conditions, it is a solid. Generally used in its purified form in laboratory settings, its stability is maintained by storing it in a cool, dry place, away from moisture.

Melting point (Celsius)
242.50
Melting point (Kelvin)
515.70
Boiling point (Celsius)
443.20
Boiling point (Kelvin)
716.40
General information
Molecular weight
347.80g/mol
Molar mass
347.7980g/mol
Density
1.3700g/cm3
Appearence

The compound is generally a solid material at room temperature. It appears as a crystalline substance and is typically off-white to pale yellow in color. Its appearance can vary slightly depending on the degree of purity and the specific form of the compound.

Comment on solubility

Solubility of 7-chloro-N-(cyclopropylmethyl)-4-hydroxy-5-phenyl-3H-1,4-benzodiazepin-2-imine

The solubility of 7-chloro-N-(cyclopropylmethyl)-4-hydroxy-5-phenyl-3H-1,4-benzodiazepin-2-imine can be influenced by several factors. Here are key aspects to consider:

  • Polarity: The presence of hydroxyl (–OH) and chloride (–Cl) groups often increases polarity, which can enhance solubility in polar solvents, such as water.
  • Solvent Choice: This compound may have variable solubility in different organic solvents. For instance, it could be poorly soluble in non-polar solvents like hexane, yet more soluble in polar solvents like methanol or ethanol.
  • Temperature: Generally, solubility tends to increase with temperature. Thus, heating the solvent may facilitate the dissolution process.
  • Structure-Activity Relationships: The bulky phenyl and cyclopropyl groups may impede solubility through steric hindrance, while the hydroxyl group could aid in hydrogen bonding with the solvent.

In summary, while the specific solubility characteristics of 7-chloro-N-(cyclopropylmethyl)-4-hydroxy-5-phenyl-3H-1,4-benzodiazepin-2-imine may not be extensively documented, understanding factors such as polarity, temperature, and solvent interactions can provide valuable insights into its solubility behavior.

Interesting facts

Interesting Facts about 7-chloro-N-(cyclopropylmethyl)-4-hydroxy-5-phenyl-3H-1,4-benzodiazepin-2-imine

This intriguing compound, part of the benzodiazepine family, showcases a unique blend of structural features that make it a subject of interest in medicinal chemistry. Benzodiazepines are widely known for their applications in treating anxiety and other mood disorders, but this specific derivative may hold even more potential.

Key Characteristics:

  • Substituted structure: The presence of a cyclopropylmethyl group is particularly interesting, as it might influence the compound's pharmacodynamics and pharmacokinetics.
  • Chlorine atom: The 7-chloro substitution could play a crucial role in enhancing the potency and stability of the compound in biological systems.
  • Hydroxy group: The 4-hydroxy moiety may impart favorable interactions with receptors, potentially leading to varied therapeutic outcomes.
  • Aromatic character: The attached phenyl ring contributes to the compound's lipophilicity, which is often crucial for drug design as it can affect membrane permeability.

This compound is a fascinating example of how slight modifications in molecular structure can vastly impact a compound's biological activity. As researchers delve deeper into understanding its mechanism of action, we can anticipate that compounds like this one may pave the way for new treatments in psychopharmacology.

In summary, the study of 7-chloro-N-(cyclopropylmethyl)-4-hydroxy-5-phenyl-3H-1,4-benzodiazepin-2-imine is not only a pursuit of understanding its properties but also a gateway to exploring innovative therapeutic avenues in medicine. As quoted by a prominent chemist, "Every molecular structure tells a story; it’s our job to listen."

Synonyms
Cyprazepam
15687-07-7
Ciprazepam
W 3623
3H-1,4-Benzodiazepin-2-amine, 7-chloro-N-(cyclopropylmethyl)-5-phenyl-, 4-oxide
7-chloro-N-(cyclopropylmethyl)-4-hydroxy-5-phenyl-3H-1,4-benzodiazepin-2-imine
933N61G4SL
7-Chloro-2-((cyclopropylmethyl)amino)-5-phenyl-3H-1,4-benzodiazepine 4-oxide
W-3623
Ciprazepam [INN-Spanish]
Cyprazepamum
Cyprazepam [USAN:INN]
Cyprazepamum [INN-Latin]
BRN 0694716
UNII-933N61G4SL
7-Chloro-2-[(cyclopropylmethyl)amino]-5-phenyl-3H-1,4-benzodiazepine 4-oxide
CYPRAZEPAM [INN]
Cyprazepam (USAN/INN)
CYPRAZEPAM [USAN]
SCHEMBL114194
CHEMBL2104165
SCHEMBL30736035
DTXSID70897505
DTXSID80864622
ZINC00001238
3H-1,4-BENZODIAZEPINE, 7-CHLORO-2-((CYCLOPROPYLMETHYL)AMINO)-5-PHENYL-, 4-OXIDE
NS00120640
D03631
Q5200296
7-Chloro-2-[(cyclopropylmethyl)imino]-5-phenyl-2,3-dihydro-4H-1,4-benzodiazepin-4-ol