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Diazepam

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Identification
Molecular formula
C16H13ClN2O2
CAS number
439-14-5
IUPAC name
7-chloro-N-methyl-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepine-3-carboxamide
State
State

At room temperature, Diazepam is a solid.

Melting point (Celsius)
131.00
Melting point (Kelvin)
404.15
Boiling point (Celsius)
350.00
Boiling point (Kelvin)
623.15
General information
Molecular weight
284.70g/mol
Molar mass
284.7040g/mol
Density
1.3000g/cm3
Appearence

Diazepam is typically seen as a white to off-white crystalline powder.

Comment on solubility

Solubility of 7-chloro-N-methyl-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepine-3-carboxamide

The solubility of 7-chloro-N-methyl-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepine-3-carboxamide can be influenced by various factors, making it an interesting compound to study in this regard.

Key Factors Affecting Solubility

  • Polarity: This compound contains both polar and nonpolar functional groups, which affects its interaction with solvents.
  • Temperature: Solubility generally increases with temperature, but the specific behavior of this compound may vary.
  • pH level: The carboxamide group can be ionized or non-ionized depending on the pH, significantly impacting solubility in aqueous solutions.

In general, the solubility of benzodiazepines tends to be variable:

  • Many are known to have moderate solubility in water.
  • Solubility may increase in organic solvents such as ethanol and dimethyl sulfoxide (DMSO).

Therefore, characterizing the solubility of this compound is crucial for its pharmaceutical applications, as poor solubility can lead to challenges in formulation and bioavailability. As the saying goes, "the solution to the drug's efficacy lies in its solubility."

Interesting facts

Interesting Facts about 7-Chloro-N-methyl-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepine-3-carboxamide

The compound 7-chloro-N-methyl-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepine-3-carboxamide belongs to a fascinating class of chemicals known as benzodiazepines. Here are some enlightening points to consider:

  • Pharmacological Importance: Benzodiazepines are widely recognized for their use as anxiolytics and sedatives. This specific compound exhibits properties that may assist in treating a variety of anxiety-related disorders.
  • Mechanism of Action: This compound functions primarily by enhancing the effect of the neurotransmitter GABA (gamma-aminobutyric acid). It binds to the GABAA receptor, thus increasing chloride ion influx and promoting a calming effect on the nervous system.
  • Structure-Activity Relationship: The modifications in the benzodiazepine structure, such as the chloro group at the 7-position, have significant implications for its biological activity. These structural changes can enhance potency, receptor affinity, and therapeutic effects.
  • Research Applications: This compound is often used in research settings to explore neuropharmacological mechanisms, as well as to develop new therapeutic agents that can leverage its unique properties.
  • Origin and Development: The development of benzodiazepines represents a milestone in medicinal chemistry, providing a safer alternative to barbiturates with reduced potential for addiction, making them pivotal in modern medicine.

As a potential subject of ongoing research, 7-chloro-N-methyl-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepine-3-carboxamide contributes to our understanding of sedative and anxiolytic drug development. Scientist continue to explore its full potential and implications in pharmacotherapy!

Synonyms
1-Methylcarbamoyldiazepam
5606-59-7
BRN 0690746
D-58M
1H-1,4-Benzodiazepine-3-carboxamide, 2,3-dihydro-7-chloro-N-methyl-2-oxo-5-phenyl-
7-Chloro-2,3-dihydro-N-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepine-3-carboxamide
SCHEMBL11834470
DTXSID30971436
7-Chloro-2-hydroxy-N-methyl-5-phenyl-3H-1,4-benzodiazepine-3-carboximidic acid