Skip to main content

Chlordiazepoxide

ADVERTISEMENT
Identification
Molecular formula
C16H14ClN3O
CAS number
58-25-3
IUPAC name
7-chloro-N,N-dimethyl-4-oxido-5-phenyl-3H-1,4-benzodiazepin-4-ium-2-amine
State
State

At room temperature, chlordiazepoxide is typically in a solid state. It is stable under ordinary conditions if protected from light and moisture.

Melting point (Celsius)
231.00
Melting point (Kelvin)
504.15
Boiling point (Celsius)
50.00
Boiling point (Kelvin)
323.15
General information
Molecular weight
299.76g/mol
Molar mass
299.7560g/mol
Density
1.4000g/cm3
Appearence

Chlordiazepoxide appears as a white or slightly yellow crystalline powder. It is practically insoluble in water, soluble in chloroform, and slightly soluble in alcohol and ether. The compound is prone to photo degradation, which can lead to discoloration upon exposure to light.

Comment on solubility

Solubility of 7-chloro-N,N-dimethyl-4-oxido-5-phenyl-3H-1,4-benzodiazepin-4-ium-2-amine

The solubility of 7-chloro-N,N-dimethyl-4-oxido-5-phenyl-3H-1,4-benzodiazepin-4-ium-2-amine is influenced by several factors. Understanding its solubility is essential for its application in various chemical and pharmaceutical processes.

  • Polarity: The presence of electron-withdrawing groups such as chlorine and the dimethylamino group affects the overall polarity of this compound. Generally, more polar compounds tend to be more soluble in polar solvents.
  • Hydrogen Bonding: The ability of the molecule to participate in hydrogen bonding also plays a crucial role in its solubility. Compounds capable of forming strong hydrogen bonds with solvents can dissolve more readily.
  • pH Sensitivity: Given its ionic nature, the solubility may vary with changes in pH. Compounds like this may exhibit different solubilities in acidic versus basic environments.
  • Solvent Choice: The choice of solvent is critical. For example, this compound may demonstrate higher solubility in organic solvents compared to water, depending on the specific interactions.

It is important to note that the quantitative solubility should be experimentally determined, as predictions can vary based on the aforementioned factors. Experimental data, therefore, remains crucial for precise application in real-world conditions.

Interesting facts

Interesting Facts About 7-Chloro-N,N-Dimethyl-4-oxido-5-phenyl-3H-1,4-benzodiazepin-4-ium-2-amine

This compound is a fascinating member of the benzodiazepine family, known for its neuroactive properties. As a potential anxiolytic agent, it showcases the intricate interplay between chemical structure and biological function. Here are some key points about this intriguing compound:

  • Benzodiazepine Backbone: As a part of the benzodiazepine family, this compound shares characteristics with widely used medications for anxiety and sleep disorders, highlighting the significance of the benzodiazepine ring in pharmaceutical chemistry.
  • Chlorine Substitution: The presence of a chlorine atom at the 7-position enhances the compound's biological activity and lipophilicity, potentially increasing its effects on the central nervous system.
  • Dimethylamino Group: The dimethylamino substitution at the nitrogen atom influences its pharmacological properties, making it more potent and allowing for better interaction with neurotransmitter receptors.
  • Oxido Group: This unique 4-oxido feature may play a crucial role in modulating the compound’s reactivity and stability, offering insight into its mechanism of action.
  • Chemical Versatility: The diverse functional groups within the structure make it a candidate for further modifications, potentially leading to the development of derivatives with unique therapeutic profiles.

Researchers continue to explore compounds like 7-chloro-N,N-dimethyl-4-oxido-5-phenyl-3H-1,4-benzodiazepin-4-ium-2-amine in the quest for new medications. Understanding the nuances of its structure can pave the way for innovative treatments in psychiatry and neurology.

Synonyms
3693-14-9
3H-1,4-BENZODIAZEPINE, 7-CHLORO-2-DIMETHYLAMINO-5-PHENYL-, 4-OXIDE
BRN 0757292
7-Chloro-2-dimethylamino-5-phenyl-3H-1,4-benzodiazepine 4-oxide
DTXSID40190419
5-25-11-00431 (Beilstein Handbook Reference)
DTXCID00112910
7-chloro-N,N-dimethyl-4-oxido-5-phenyl-3H-1,4-benzodiazepin-4-ium-2-amine
7-Chloro-2-(dimethylamino)-5-phenyl-3H-1,4-benzodiazepine 4-oxide
7-Chloro-2-(dimethylamino)-5-phenyl3H-benzo[e] [1,4]diazepine 4-oxide