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7-Chloro-2-aminoacridine

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Identification
Molecular formula
C13H9ClN2
CAS number
86-45-3
IUPAC name
7-chloroacridin-2-amine
State
State

At room temperature, 7-Chloro-2-aminoacridine is in a solid state. The compound usually exists as crystalline powder or shards.

Melting point (Celsius)
226.00
Melting point (Kelvin)
499.15
Boiling point (Celsius)
335.00
Boiling point (Kelvin)
608.15
General information
Molecular weight
216.68g/mol
Molar mass
216.6750g/mol
Density
1.4245g/cm3
Appearence

7-Chloro-2-aminoacridine appears as a yellow to reddish-brown crystalline solid. It has a distinctive appearance, often forming as lustrous crystals.

Comment on solubility

Solubility of 7-chloroacridin-2-amine

The solubility of 7-chloroacridin-2-amine, a compound featuring a unique arrangement of nitrogen and chlorine atoms, can be influenced by several factors including temperature, pH, and the solvent used. Generally, it is important to consider the following points regarding its solubility:

  • Polarity: 7-chloroacridin-2-amine exhibits a polar structure due to the presence of the amino group, which can enhance its solubility in polar solvents like water and alcohols.
  • Solvent Effects: While it may dissolve well in certain organic solvents, its solubility in non-polar solvents is expected to be limited, making them ineffective for dissolution.
  • Temperature Influence: An increase in temperature often enhances solubility; thus, heating may aid in obtaining a more concentrated solution of 7-chloroacridin-2-amine.
  • pH Sensitivity: The solubility can also vary with changes in pH levels. In acidic conditions, 7-chloroacridin-2-amine may form salts that improve its solubility in aqueous solutions.

In summary, the solubility of 7-chloroacridin-2-amine is a multifaceted topic influenced by various environmental conditions. Understanding these factors is crucial for effectively utilizing this compound in both laboratory and industrial applications.

Interesting facts

Interesting Facts about 7-Chloroacridin-2-amine

7-Chloroacridin-2-amine is a fascinating compound that belongs to the acridine family, a group of nitrogen-containing heterocycles known for their diverse biological and chemical properties. Here are some intriguing aspects of this compound:

  • Biological Activity: Compounds in the acridine class have demonstrated a variety of biological activities, making them pivotal in medicinal chemistry. Many acridine derivatives, including 7-chloroacridin-2-amine, exhibit antimalarial, antibacterial, and anticancer properties.
  • Applications in Research: Researchers are investigating 7-chloroacridin-2-amine due to its potential as a lead compound for developing pharmaceuticals. Its unique structure allows it to interact with biological targets effectively.
  • Photophysical Properties: The electronic characteristics of the acridine framework enable these compounds to absorb light efficiently, which is a significant property in developing fluorescent probes and sensors.
  • Historical Significance: The study of acridine derivatives began in the late 19th century, and their roles in biological systems have been elucidated over the years. 7-Chloroacridin-2-amine fits into this historical narrative as scientists continue to explore its mechanisms of action.
  • Structure-Activity Relationship (SAR): Understanding the relationship between the structure of 7-chloroacridin-2-amine and its biological activity is crucial. Small modifications in its structure can lead to significant changes in efficacy, toxicity, and pharmacokinetics.

In conclusion, 7-chloroacridin-2-amine not only embodies the complexity and beauty of organic chemistry but also serves as a bridge between synthetic chemistry and medicinal applications. As researchers continue to uncover more about this compound, who knows what exciting discoveries await in its molecular composition!

Synonyms
23045-20-7
7-chloroacridin-2-amine
ACRIDINE, 2-AMINO-7-CHLORO-
7-Chloro-2-acridinamine
BRN 0165764
2-Amino-7-chloroacridine (European)
starbld0045640
Acridine 2-amino-7-chloro-
orb1986613
SCHEMBL17423275
DTXSID40177609
AKOS040750117