Skip to main content

Clioquinol

ADVERTISEMENT
Identification
Molecular formula
C9H5ClINO
CAS number
130-26-7
IUPAC name
7-chloroquinolin-8-ol
State
State

At room temperature, clioquinol is a solid powder. It is stable under normal temperatures and pressures and is typically stored in a well-ventilated place away from moisture and incompatible substances.

Melting point (Celsius)
173.00
Melting point (Kelvin)
446.15
Boiling point (Celsius)
310.00
Boiling point (Kelvin)
583.15
General information
Molecular weight
305.50g/mol
Molar mass
305.5000g/mol
Density
1.5980g/cm3
Appearence

Clioquinol appears as a light yellow to pale orange crystalline powder. It is known for its slight odor and bitter taste. The compound is typically used in a variety of applications including as an antimicrobial agent.

Comment on solubility

Solubility of 7-chloroquinolin-8-ol

7-chloroquinolin-8-ol, often noted for its unique structural properties, exhibits a range of solubility characteristics that can impact its usage in various applications.

Solubility in Solvents

This compound is:

  • Soluble in organic solvents such as ethanol and methanol.
  • Less soluble in water, which could limit its bioavailability and effectiveness in aqueous environments.
  • Prone to form hydrogen bonds, which may influence solubility in polar solvents.

Factors Affecting Solubility

Several factors play a crucial role in determining the solubility of 7-chloroquinolin-8-ol:

  • Temperature: An increase in temperature generally enhances solubility, making it an essential consideration in practical applications.
  • pH Level: The compound's solubility can vary with changes in pH, often showing increased solubility in alkaline conditions due to deprotonation.

In summary, while 7-chloroquinolin-8-ol shows good solubility in organic solvents, its limited solubility in water poses challenges for certain formulations. Understanding these solubility properties is vital for optimizing its use in pharmaceutical and chemical synthesis applications.

Interesting facts

Interesting Facts about 7-Chloroquinolin-8-ol

7-Chloroquinolin-8-ol, also known as a derivative of quinoline, is a fascinating compound with numerous applications in the fields of chemistry and pharmacology. Here are some intriguing aspects that underscore its significance:

  • Antimicrobial Properties: This compound has been studied for its effectiveness against various bacterial and fungal pathogens, making it a potential candidate for developing new antibiotics.
  • Pharmaceutical Relevance: 7-chloroquinolin-8-ol is often utilized as an intermediate in the synthesis of various therapeutic agents. Its derivatives have shown promise in treating diseases such as malaria and certain types of cancers.
  • Chemical Versatility: The structure of this compound allows for multiple substitutions at different positions, leading to a diverse range of derivatives that can be tailored for specific applications.
  • Biological Mechanism: Researchers have been exploring how this compound interacts with biological systems, particularly its role in cell signaling and metabolic processes. Its mechanism of action often involves interacting with key enzymes or receptors.
  • Research and Development: Ongoing studies are focused on enhancing the pharmacological properties of 7-chloroquinolin-8-ol to increase its efficacy and reduce potential side effects in medicinal contexts.

As a chemistry student, delving into the studies surrounding 7-chloroquinolin-8-ol opens doors to understanding not only its chemical properties but also its potential impacts in medicine and biochemistry. As noted by researchers, "The exploration of quinoline derivatives has led to the discovery of numerous bioactive compounds that highlight the beauty of organic chemistry." This compound exemplifies the intersection of chemical innovation and practical application, showcasing how simple structures can lead to profound outcomes.

Synonyms
7-Chloroquinolin-8-ol
876-86-8
7-Chloro-8-quinolinol
NSC673451
K9AEQ8892Y
MFCD11870758
7-Chloro-8-hydroxyquinoline
UNII-K9AEQ8892Y
EINECS 212-882-6
SCHEMBL114706
CHEMBL141396
quinoline, 7-chloro-8-hydroxy-
RMJFNYXBFISIET-UHFFFAOYSA-
DTXSID90236513
RMJFNYXBFISIET-UHFFFAOYSA-N
SMSSF-0625259
AKOS016009079
AMS_CNC_ID-408616015
NSC-673451
SB67730
AS-50264
NCI60_026021
SY152261
CS-0155828
NS00039210
EN300-132918
O11652
Q27282126
InChI=1/C9H6ClNO/c10-7-4-3-6-2-1-5-11-8(6)9(7)12/h1-5,12H