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Amlexanox

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Identification
Molecular formula
C17H23Cl2N
CAS number
68302-57-8
IUPAC name
[7-(dimethylammonio)-4-[2-(2-phenylethyl)phenyl]hept-3-enyl]-dimethyl-ammonium;dichloride
State
State

Amlexanox is typically found in a solid state at room temperature. It is stable under normal conditions and is commonly used in its solid form for compounded topical treatments.

Melting point (Celsius)
143.00
Melting point (Kelvin)
416.15
Boiling point (Celsius)
433.15
Boiling point (Kelvin)
706.30
General information
Molecular weight
502.45g/mol
Molar mass
502.4520g/mol
Density
1.2300g/cm3
Appearence

Amlexanox, as the dichloride salt, typically appears as a white to off-white crystalline powder, suitable for use in pharmaceutical formulations. It is often formulated for topical administration and thus generally has a fine crystalline texture.

Comment on solubility

Solubility of [7-(dimethylammonio)-4-[2-(2-phenylethyl)phenyl]hept-3-enyl]-dimethyl-ammonium;dichloride

The compound [7-(dimethylammonio)-4-[2-(2-phenylethyl)phenyl]hept-3-enyl]-dimethyl-ammonium;dichloride is a quaternary ammonium salt, which generally influences its solubility characteristics significantly. When discussing the solubility of such compounds, several key points should be considered:

  • Nature of the Compound: Quaternary ammonium salts like this one tend to be soluble in polar solvents, such as water and alcohols, due to their ionic nature.
  • Influence of Chloride Ions: The presence of chloride ions can enhance solubility by stabilizing the ionic interactions in solution.
  • Hydrophobic Groups: The bulky phenylethyl groups attached to the ammonium moiety may introduce hydrophobic characteristics, which can affect solubility in various solvents.
  • pH Dependency: As with many ionic compounds, solubility can vary with pH, potentially leading to greater solubility in acidic conditions.

In summary, while [7-(dimethylammonio)-4-[2-(2-phenylethyl)phenyl]hept-3-enyl]-dimethyl-ammonium;dichloride is expected to be soluble in polar solvents, its overall solubility behavior will depend on multiple factors, including ionic interactions and the presence of hydrophobic substituents. Thus, experimental determination in various solvents is recommended for a comprehensive understanding of its solubility profile.

Interesting facts

Interesting Facts about [7-(dimethylammonio)-4-[2-(2-phenylethyl)phenyl]hept-3-enyl]-dimethyl-ammonium;dichloride

This compound, whose name reflects its complex structure, belongs to a fascinating class of quaternary ammonium compounds. These are known for their diverse applications in various fields, including medicine, biochemistry, and materials science. Here are some intriguing aspects to consider:

  • Structural Diversity: The compound features a distinct heptenyl chain, which plays a crucial role in its functional properties. This chain provides the ability to modify the compound's reactivity and solubility.
  • Biological Applications: Quaternary ammonium compounds, like this one, often exhibit antimicrobial properties. They are widely used in disinfectants, antiseptics, and even in drug formulations to enhance bioavailability.
  • Dimethylammonium Functionality: The presence of dimethylammonio groups contributes to the compound's cationic character, making it highly effective in binding to anionic surfaces, such as bacterial membranes.
  • Phenylethyl Substituent: The incorporation of a phenylethyl group adds another layer of complexity, leading to potential applications in pharmaceutical formulations targeting the central nervous system due to its structural similarity to neurotransmitters.
  • Gradient of Polarity: The varying polarity throughout the molecule supports its ability to interact with both hydrophilic and hydrophobic environments, making it a versatile candidate in formulation chemistry.

Overall, the intricacies of [7-(dimethylammonio)-4-[2-(2-phenylethyl)phenyl]hept-3-enyl]-dimethyl-ammonium;dichloride highlight the significant role of molecular structure in determining the functional properties of chemical compounds. As such, understanding its dynamics can lead to remarkable innovations in both industrial and therapeutic applications.