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Loperamide hydrochloride

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Identification
Molecular formula
C29H33Cl2N2O
CAS number
34552-83-5
IUPAC name
[7-(dimethylammonio)-4-hydroxy-4-[2-(2-phenylethyl)phenyl]heptyl]-dimethyl-ammonium;dichloride
State
State

At room temperature, loperamide hydrochloride is in a solid state.

Melting point (Celsius)
222.00
Melting point (Kelvin)
495.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
513.51g/mol
Molar mass
513.5080g/mol
Density
0.0012g/cm3
Appearence

Loperamide hydrochloride usually appears as an odorless, white to off-white crystalline powder.

Comment on solubility

Solubility of [7-(dimethylammonio)-4-hydroxy-4-[2-(2-phenylethyl)phenyl]heptyl]-dimethyl-ammonium;dichloride

This compound, which includes a quaternary ammonium ion structure, exhibits interesting solubility characteristics influenced by its complex molecular structure. The presence of the dichloride moiety generally suggests good solubility in polar solvents due to ionic interactions. Here are some key aspects to consider regarding its solubility:

  • Polar Solvents: The ionic nature owing to the quaternary ammonium suggests that the compound is likely to be soluble in water and other polar solvents.
  • Non-Polar Solvents: Due to the large hydrophobic aromatic groups present, solubility in non-polar solvents may be limited.
  • Hydrophobic Effects: The presence of bulky groups could lead to decreased solubility as the hydrophobic interactions dominate.
  • Concentration Dependence: Solubility may vary widely with changes in temperature or concentration, necessitating careful consideration in experimental conditions.

In summary, while the ionic character indicates a tendency for solubility in aqueous environments, the overall structure with extensive hydrophobic regions plays a critical role. Therefore, it is essential to evaluate this compound's solubility in context, bringing together both its polar and non-polar attributes. As one might say, “solubility is a dance of competition between hydrophilic and hydrophobic forces,” making it an intriguing area of study for this compound.

Interesting facts

Interesting Facts about 7-(Dimethylammonio)-4-hydroxy-4-[2-(2-phenylethyl)phenyl]heptyl-dimethyl-ammonium;dichloride

This fascinating compound belongs to a unique class of quaternary ammonium compounds, which are known for their versatility and efficacy in various applications. Let’s explore some intriguing aspects of this compound:

  • Ammonium Structure: The presence of the dimethylammonio group is significant as it contributes to the compound's quaternary nature, allowing it to interact effectively with biological membranes.
  • Phenylethyl Groups: The two phenylethyl groups attached in the structure suggest potential applications in pharmaceuticals, particularly in the field of neurochemistry and drug design. The influence of aromatic structures can enhance the lipophilicity and biological activity of compounds.
  • Hydroxy Functionality: The hydroxy (-OH) group is a functional motif that can engage in hydrogen bonding, potentially increasing the compound's solubility and interaction with biomolecules.
  • Biological Implications: Quaternary ammonium compounds like this one are often studied for their antimicrobial properties. They can act as surfactants or active agents in formulations aimed at combating bacterial growth.
  • Research Potential: Compounds with similar structures are at the forefront of research in drug delivery systems, due to their ability to modulate drug release and improve bioavailability.

As a scientist exploring this compound, one might reflect that “the chemistry of life is written in the language of molecules.” The intricate arrangement of atoms within 7-(dimethylammonio)-4-hydroxy-4-[2-(2-phenylethyl)phenyl]heptyl-dimethyl-ammonium;dichloride not only influences its function but also illuminates pathways for future innovations in health and materials science.

Synonyms
4-HEPTANOL, 1,7-BIS(DIMETHYLAMINO)-4-(o-PHENETHYLPHENYL)-, DIHYDROCHLORIDE
1,7-Bis(dimethylamino)-4-(2-(2-phenylethyl)phenyl)heptan-4-ol dihydrochloride
5505-03-3