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Enrofloxacin

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Identification
Molecular formula
C19H22FN3O3
CAS number
93106-60-6
IUPAC name
7-fluoro-8-(4-hydroxy-1-piperidyl)-12-methyl-4-oxo-1-azatricyclo[7.3.1.05,13]trideca-2,5,7,9(13)-tetraene-3-carboxylic acid
State
State

Enrofloxacin is a solid at room temperature, generally provided as a crystalline powder for veterinary applications.

Melting point (Celsius)
221.00
Melting point (Kelvin)
494.00
Boiling point (Celsius)
637.20
Boiling point (Kelvin)
910.40
General information
Molecular weight
359.40g/mol
Molar mass
359.4000g/mol
Density
1.6000g/cm3
Appearence

Enrofloxacin is a pale yellow solid. It typically appears as crystalline powder.

Comment on solubility

Solubility of 7-fluoro-8-(4-hydroxy-1-piperidyl)-12-methyl-4-oxo-1-azatricyclo[7.3.1.05,13]trideca-2,5,7,9(13)-tetraene-3-carboxylic acid

The solubility characteristics of the compound with the chemical formula C19H22FN3O3 can be quite fascinating. Generally, the solubility of a compound is influenced by several factors, including its molecular structure, polarity, and the presence of functional groups.

Key Factors Influencing Solubility:

  • Polarity: The more polar a compound, the more likely it is to dissolve in polar solvents, such as water.
  • Functional Groups: In this compound, the presence of the carboxylic acid functional group typically enhances solubility in water due to its ability to ionize and interact with water molecules.
  • Hydrophobic Regions: The tricyclic structure may provide hydrophobic regions that can limit solubility in polar solvents.

In particular, it’s important to note that:

  • This compound is expected to have moderate solubility in water due to the presence of the carboxylic acid and hydroxyl groups.
  • However, the overall solubility may be compromised by its large hydrophobic tricyclic structure.

It is likely that this compound exhibits better solubility in organic solvents compared to water, given the balance of hydrophilic and hydrophobic components in its molecular design. Understanding the solubility behavior of this molecule could lead to important insights, especially in fields such as pharmaceutical development and material science.

Interesting facts

Interesting Facts about 7-fluoro-8-(4-hydroxy-1-piperidyl)-12-methyl-4-oxo-1-azatricyclo[7.3.1.05,13]trideca-2,5,7,9(13)-tetraene-3-carboxylic acid

This compound, known for its complex structure, belongs to a class of chemical entities that exhibit remarkable biological activities. Here are some fascinating insights about it:

  • Fluorinated Component: The presence of a fluorine atom in its structure contributes to increased lipophilicity, potentially enhancing the compound's ability to cross biological membranes.
  • Piperidine Ring: The inclusion of a piperidine moiety can often improve pharmacological properties and is frequently utilized in medicinal chemistry to develop drugs with higher potency and selectivity.
  • Biological Relevance: Compounds of this nature may interact with various biological targets, which could lead to significant therapeutic effects, including analgesic or antipsychotic activities.
  • Complex Framework: Its intricate tricyclic structure not only showcases intricate synthetic challenges but also serves as a basis for the exploration of various analogs that may have improved efficacy.
  • Research Applications: This chemical may be a subject of research in fields such as neuropharmacology, where understanding its action mechanism can unveil insights into psychological disorders.

As you delve deeper into the world of this compound, keep in mind that each modification to its structure can lead to a new avenue of exploration, leading to innovative therapeutic advancements. The study of such compounds underlines the inherent beauty and complexity of organic chemistry.

Synonyms
nadifloxacin
124858-35-1
jinofloxacin
Acuatim
OPC-7251
Nadifloxacine
Nadixa
Opc 7251
Nadifloxacino
S-Nadifloxacin
Nadifloxacinum
Nadifloxacine [INN-French]
Nadifloxacinum [INN-Latin]
Nadifloxacino [INN-Spanish]
CCRIS 4066
CHEBI:31889
6CL9Y5YZEQ
Acuatim (TN)
NSC-759622
Nadifloxacin [INN:BAN:JAN]
DTXSID5046483
MFCD00865081
NADIFLOXACIN [MI]
1H,5H-Benzo[ij]quinolizine-2-carboxylic acid, 9-fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-
NADIFLOXACIN [INN]
NADIFLOXACIN [JAN]
NADIFLOXACIN [MART.]
NADIFLOXACIN [WHO-DD]
DTXCID3026483
OPC7251
NSC 759622
9-fluoro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1,5,6,7-tetrahydropyrido[3,2,1-ij]quinoline-2-carboxylic acid
9-fluoro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid
NCGC00164620-01
Nadifloxacine (INN-French)
Nadifloxacinum (INN-Latin)
Nadifloxacino (INN-Spanish)
NADIFLOXACIN (MART.)
1H,5H-Benzo(ij)quinolizine-2-carboxylic acid, 9-fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-
7-fluoro-8-(4-hydroxypiperidin-1-yl)-12-methyl-4-oxo-1-azatricyclo[7.3.1.0^{5,13}]trideca-2,5(13),6,8-tetraene-3-carboxylic acid
7-fluoro-8-(4-hydroxypiperidin-1-yl)-12-methyl-4-oxo-1-azatricyclo[7.3.1.05,13]trideca-2,5,7,9(13)-tetraene-3-carboxylic acid
(+/-)-9-FLUORO-6,7-DIHYDRO-8-(4-HYDROXYPIPERIDINO)-5-METHYL-1-OXO-1H,5H-BENZO(IJ)QUINOLIZINE-2-CARBOXYLIC ACID
CAS-124858-35-1
S-NDFX
SR-05000001516
UNII-6CL9Y5YZEQ
Nadoxin
1H,5H-BENZO(IJ)QUINOLIZINE-2-CARBOXYLIC ACID, 9-FLUORO-6,7-DIHYDRO-8-(4-HYDROXY-1-PIPERIDINYL)-5-METHYL-1-OXO-, (+/-)-
1H,5H-Benzo[ij]quinolizine-2-carboxylic acid, 9-fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-, (+/-)-
7-fluoro-8-(4-hydroxypiperidin-1-yl)-12-methyl-4-oxo-1-azatricyclo(7.3.1.05,13)trideca-2,5,7,9(13)-tetraene-3-carboxylic acid
9-fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidyl)-5-methyl-1-oxo-1H,5H-benzo(i,j)quinolizine-2-carboxylic acid
9-fluoro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-6,7-dihydro-1H,5H-pyrido(3,2,1-ij)quinoline-2-carboxylic acid
NDFX
Nadifloxacin (JAN/INN)
SCHEMBL36593
1H,5H-Benzo(ij)quinolizine-2-carboxylic acid, 9-fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-, (+-)-
MLS002154166
CHEMBL363449
GTPL12919
D10AF05
HMS2090D11
HMS2098O22
HMS2233D22
HMS3373H17
HMS3651J22
HMS3715O22
Pharmakon1600-01502312
BCP05205
HY-B0506
Tox21_112239
BDBM50475222
NSC759622
s3105
AKOS015895271
Tox21_112239_1
AC-4283
AF26117
BCP9000975
CCG-213817
DB12447
KS-1210
SB17161
NCGC00164620-02
(+-)-9-Fluoro-6,7-dihydro-8-(4-hydroxypiperidino)-5-methyl-1-oxo-1H,5H-benzo(ij)quinolizine-2-carboxylic acid
SMR001233465
SY053145
SY343606
DB-041783
N0931
NS00002824
SW199586-2
D01147
AB00918517-07
AB00918517_08
AB00918517_09
Q426605
SR-05000001516-1
SR-05000001516-3
BRD-A24397426-001-09-6
BRD-A24397426-001-10-4
(S)-9-Fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidyl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic Acid
8-(4-hydroxy-1-piperidyl)-9-fluoro-5-methyl-6,7-dihydro-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid
9-Fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid;Jinofloxacin;OPC-7251
9-Fluoro-6,7-dihydro-8-(4-hydroxypiperidino)-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid
9-Fluoro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-1,5,6,7-tetrahydropyrido[3,2,1-ij]quinoline-2-carboxylic Acid
9-Fluoro-8-(4-hydroxy-1-piperidyl)-5-methyl-1-oxo-1,5,6,7-tetrahydropyrido[3,2,1-ij]quinoline-2-carboxylic Acid
9-fluoro-8-(4-hydroxy-1-piperidyl)-5-methyl-6,7-dihydro-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid
9-fluoro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1,5,6,7-tetrahydropyrido[3,2,1-ij]quinoline-2-carboxylicacid