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7-(Hydroxymethyl)-2,3,5,8-tetrahydro-1H-pyrrolizin-1-ol

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Identification
Molecular formula
C8H13NO2
CAS number
141-77-9
IUPAC name
7-(hydroxymethyl)-2,3,5,8-tetrahydro-1H-pyrrolizin-1-ol
State
State

At room temperature, 7-(Hydroxymethyl)-2,3,5,8-tetrahydro-1H-pyrrolizin-1-ol is typically found in a solid state. The compound is usually stored in airtight containers to prevent moisture uptake due to its slightly hygroscopic nature.

Melting point (Celsius)
87.00
Melting point (Kelvin)
360.00
Boiling point (Celsius)
259.00
Boiling point (Kelvin)
532.00
General information
Molecular weight
141.20g/mol
Molar mass
141.1950g/mol
Density
1.1639g/cm3
Appearence

The compound typically appears as a colorless to light yellow crystalline solid. It may be slightly hygroscopic and should be handled in an environment with controlled moisture. It has a slight odor that can be somewhat reminiscent of aromatic heterocycles.

Comment on solubility

Solubility of 7-(hydroxymethyl)-2,3,5,8-tetrahydro-1H-pyrrolizin-1-ol

The solubility of 7-(hydroxymethyl)-2,3,5,8-tetrahydro-1H-pyrrolizin-1-ol is an important aspect to consider for its practical applications in various fields. This compound has both hydrophilic and hydrophobic characteristics due to the presence of hydroxymethyl groups and the cyclic structure of the pyrrolizin moiety.

Key Points on Solubility:

  • Water Solubility: The hydroxymethyl group is likely to enhance its solubility in water, making it soluble to a reasonable extent in aqueous solutions.
  • Organic Solvents: It may have good solubility in organic solvents such as ethanol and methanol, which could be beneficial for various chemical reactions and formulations.
  • Temperature Dependency: As with many organic compounds, its solubility may increase with rising temperatures.

In summary, while 7-(hydroxymethyl)-2,3,5,8-tetrahydro-1H-pyrrolizin-1-ol displays a degree of solubility in both water and organic solvents, the extent of solubility will depend significantly on the surrounding conditions, such as temperature and the solvent type. This dual solubility can open pathways for various applications and reactions in organic chemistry.

Interesting facts

Interesting Facts About 7-(Hydroxymethyl)-2,3,5,8-tetrahydro-1H-pyrrolizin-1-ol

7-(Hydroxymethyl)-2,3,5,8-tetrahydro-1H-pyrrolizin-1-ol is a fascinating compound that belongs to the class of pyrrolizidine alkaloids. These compounds often present intriguing characteristics that are the subject of extensive research. Here are some interesting aspects:

  • Biological Significance: This compound has been studied for its potential biological activities, including *antimicrobial* and *cytotoxic effects*. Such properties make it an interesting candidate for pharmaceutical applications, especially in the development of new drugs.
  • Natural Occurrence: Pyrrolizidine alkaloids are often found in various plants, particularly in the family *Boraginaceae*. Understanding the biosynthetic pathways of these compounds provides insight into plant metabolism and adaptation.
  • Regulatory Concerns: Some pyrrolizidine alkaloids are known to be toxic and pose health risks. Consequently, regulations have been established regarding their presence in food and herbal products, making safety studies essential.
  • Synthetic Accessibility: The ability to synthesize compounds such as this allows chemists to explore their derivatives and analogs. This synthetic route can contribute to a library of compounds for biological testing and lead to the discovery of novel pharmaceuticals.
  • Research Topics: Current research often focuses on the *mechanisms of action* and *metabolism* of pyrrolizidine alkaloids. This research can elucidate the pharmacological profile and potential therapeutic benefits of 7-(hydroxymethyl)-2,3,5,8-tetrahydro-1H-pyrrolizin-1-ol.

In summary, 7-(hydroxymethyl)-2,3,5,8-tetrahydro-1H-pyrrolizin-1-ol represents a prominent subject of investigation within the field of organic and medicinal chemistry. Its biological activities and natural abundance signal exciting prospects for further exploration in medicine and toxicology.

Synonyms
7-(hydroxymethyl)-2,3,5,8-tetrahydro-1H-pyrrolizin-1-ol
1H-Pyrrolizine-7-methanol, 2,3,5,7a-tetrahydro-1-hydroxy-, (1S-cis)-
SCHEMBL10761428
DTXSID40871670
NSC124684
AKOS040734804
WLN: T55 AN CUTJ D1Q FQ -IS-CIS
7-(Hydroxymethyl)-2,3,5,7a-tetrahydro-1H-pyrrolizin-1-ol
1H-Pyrrolizine-7-methanol,3,5,7a-tetrahydro-1-hydroxy-, (1S-cis)-