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Nifuroxazide

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Identification
Molecular formula
C15H14ClNO4
CAS number
965-52-6
IUPAC name
(7-methoxy-3-methyl-4-oxo-2-phenyl-chromen-8-yl)methyl-dimethyl-ammonium;chloride
State
State

At room temperature, nifuroxazide is a solid. It is a crystalline powder that is stable under normal conditions but should be stored in a dry, cool place away from sunlight.

Melting point (Celsius)
210.00
Melting point (Kelvin)
483.15
Boiling point (Celsius)
135.00
Boiling point (Kelvin)
408.15
General information
Molecular weight
275.70g/mol
Molar mass
275.6980g/mol
Density
1.2200g/cm3
Appearence

Nifuroxazide typically appears as a yellow-odorless crystalline powder.

Comment on solubility

Solubility of (7-methoxy-3-methyl-4-oxo-2-phenyl-chromen-8-yl)methyl-dimethyl-ammonium;chloride

The solubility of (7-methoxy-3-methyl-4-oxo-2-phenyl-chromen-8-yl)methyl-dimethyl-ammonium;chloride can be categorized based on various factors that influence its interaction with solvents:

  • Polarity: The presence of the quaternary ammonium group contributes to the overall polarity of the compound, which typically enhances its solubility in polar solvents like water.
  • Solvent Compatibility: This compound is more likely to be soluble in polar aprotic solvents, such as dimethyl sulfoxide (DMSO) or acetonitrile, due to the ionic nature imparted by the chloride ion.
  • Concentration Effect: Like many salts, (7-methoxy-3-methyl-4-oxo-2-phenyl-chromen-8-yl)methyl-dimethyl-ammonium;chloride may exhibit higher solubility at increased temperatures, enhancing its dispersion in solutions.
  • Structural Influences: The bulky terrylene unit may create steric hindrances, potentially affecting how freely the compound interacts with solvent molecules.

In summary, the solubility of this compound is influenced by its ionic nature and structural characteristics, making it generally soluble in polar solvents but necessitating specific conditions to optimize solubility.

Interesting facts

Exploring (7-methoxy-3-methyl-4-oxo-2-phenyl-chromen-8-yl)methyl-dimethyl-ammonium;chloride

This fascinating compound belongs to the class of quaternary ammonium compounds, and its unique structure contributes to its intriguing chemical behavior and potential applications. Here are some of the noteworthy aspects of this compound:

  • Bioactive Properties: Many chromene derivatives, including this compound, exhibit a range of biological activities, such as anti-inflammatory, anticancer, and antimicrobial effects. The presence of the methoxy and methyl groups plays a significant role in enhancing these properties.
  • Photochemical Applications: The chromene backbone is known for its ability to undergo various photochemical reactions. This property makes it a candidate for use in materials that require light sensitivity, such as in photovoltaics or light-activated therapeutics.
  • Quaternary Ammonium Feature: As a quaternary ammonium compound, it exhibits cationic properties, which can lead to increased solubility in water and can influence its interactions in biological systems.
  • Versatile Synthesis: The synthesis of this compound can be accomplished through diverse reaction pathways, allowing scientists to explore modifications that may optimize its physical and chemical properties for specific applications.
  • Research Interest: This compound has caught the attention of researchers in medicinal chemistry, as they explore the potential of chromene-based structures for drug development. The versatility of the chromene core offers a promising scaffold for further functionalization.

In summary, the compound (7-methoxy-3-methyl-4-oxo-2-phenyl-chromen-8-yl)methyl-dimethyl-ammonium;chloride is a remarkable example of how synthetic chemistry can create molecular structures with diverse and beneficial properties. Its ongoing exploration has the potential to uncover new avenues in both scientific research and practical applications.

Synonyms
H0XB4R74ID
(7-methoxy-3-methyl-4-oxo-2-phenylchromen-8-yl)methyl-dimethylazanium;chloride
NSC114650
4H-1-Benzopyran-4-one, 8-((dimethylamino)methyl)-7-methoxy-3-methyl-2-phenyl-, hydrochloride
Remefline
Dimefline hydrochloride [USAN:JAN]
EINECS 220-366-7
NSC 114650
UNII-H0XB4R74ID
3-Methyl-7-methoxy-8-(dimethylamino-methyl)-flavone hydrochloride
FLAVONE, 8-((DIMETHYLAMINO)METHYL)-7-METHOXY-3-METHYL-, HYDROCHLORIDE
REC 7-0267