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Scopoletin

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Identification
Molecular formula
C10H8O4
CAS number
92-61-5
IUPAC name
7-methoxychromen-2-one
State
State

At room temperature, scopoletin is generally a solid. Its stability and form as a crystal make it suitable for various uses and studies in both laboratory and industrial settings.

Melting point (Celsius)
204.00
Melting point (Kelvin)
477.15
Boiling point (Celsius)
401.80
Boiling point (Kelvin)
674.95
General information
Molecular weight
192.17g/mol
Molar mass
192.1660g/mol
Density
1.3100g/cm3
Appearence

Scopoletin appears as a crystalline solid that can range from colorless to white. It is commonly found in nature as a constituent of various plants and exhibits fluorescence under ultraviolet light, which makes it visually distinctive in certain testing environments.

Comment on solubility

Solubility of 7-methoxychromen-2-one

7-methoxychromen-2-one, also known by its common name, is a compound that presents interesting solubility characteristics:

  • Solvent Dependence: The solubility of 7-methoxychromen-2-one significantly varies with different solvents. In general, it is found to be sparingly soluble in water, but exhibits greater solubility in organic solvents.
  • Organic Solvents: This compound demonstrates a notable solubility in solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO). This is largely due to its non-polar moiety, making it better suited for non-polar environments.
  • Temperature Influence: As with many organic compounds, the solubility of 7-methoxychromen-2-one can increase with temperature. Heating the solvent may enhance its ability to dissolve the compound.

In summary, while 7-methoxychromen-2-one has limited solubility in aqueous environments, it is readily soluble in many organic solvents, which can be an important consideration for its applications in various fields, including pharmaceuticals and biochemistry. This characteristic makes it versatile when formulating solutions or extracts where this compound is desired.

Interesting facts

Exploring 7-Methoxychromen-2-one

7-Methoxychromen-2-one, also known as 7-methoxyflavone, is a fascinating compound within the diverse family of flavonoids. These compounds are renowned for their wide array of biological activities and health benefits. Here are some intriguing aspects of 7-methoxychromen-2-one:

  • Natural Occurrence: This compound is predominantly found in several plant species, especially in those with traditional medicinal uses. Its presence in nature has led scientists to explore its potential therapeutic properties.
  • Biological Activity: 7-Methoxychromen-2-one is noted for its anti-inflammatory, antioxidant, and anticancer properties. Research has shown that flavonoids like 7-methoxychromen-2-one have the ability to scavenge free radicals, which can help in preventing oxidative stress-related diseases.
  • Potential in Medicine: Some studies have suggested that compounds like 7-methoxychromen-2-one may also possess neuroprotective effects, indicating potential applications in treating neurodegenerative diseases such as Alzheimer’s and Parkinson’s.
  • Chemical Versatility: The structural framework of 7-methoxychromen-2-one allows for various chemical modifications, making it a versatile candidate for synthetic chemists aiming to develop new derivatives with enhanced biological activity.
  • Flavor and Aroma: Interestingly, compounds derived from the chromenone family can contribute to the flavor and aroma profiles of certain foods and beverages, reflecting the intersection of chemistry with gastronomy.

In conclusion, 7-methoxychromen-2-one exemplifies how a single compound can open numerous avenues of scientific inquiry. Its presence in nature, coupled with its potential health benefits and versatility, underscores the importance of flavonoids in both medicinal chemistry and pharmacognosy. As research continues, we may unravel even more about this intriguing compound and its possible roles in health and disease management.

Synonyms
7-Methoxycoumarin
Herniarin
Ayapanin
Herniarine
7-Methoxy-2H-1-benzopyran-2-one
Coumarin, 7-methoxy-
METHOXYCOURMARIN, 7-
NSC 404559
7-(methyloxy)-2H-chromen-2-one
EINECS 208-513-3
UNII-DGK72G008A
BRN 0141728
CHEBI:5679
DGK72G008A
NSC-404559
METHOXYCOUMARIN, 7-
5-18-01-00387 (Beilstein Handbook Reference)
7-METHOXYCOUMARIN (CONSTITUENT OF CHAMOMILE)
208-513-3
531-59-9
7-Methoxy-2H-chromen-2-one
Methylumbelliferone
7-methoxychromen-2-one
2H-1-BENZOPYRAN-2-ONE, 7-METHOXY-
Methyl umbelliferyl ether
7-methoxy-chromen-2-one
7-methoxy-coumarin
MFCD00006876
7-Methoxy Coumarin
CHEMBL49732
7-Methoxycoumarin;Methyl umbelliferyl ether
7-Methyl ether derivative of Umbelliferone
7-Methoxycoumarin, >=98%
SMR000156201
Herniarin (6CI)
Umbelliferone methyl ether
Herniarin (standard)
Spectrum_000392
SpecPlus_000322
Spectrum2_000398
Spectrum3_000263
Spectrum4_001558
Spectrum5_000156
7-METHOXYCOURMARIN
Umbelliferone, methyl ether
SCHEMBL61221
BSPBio_001706
KBioGR_002056
KBioSS_000872
SPECTRUM210874
MLS000563125
MLS000574914
DivK1c_006418
SPBio_000615
7-methoxy-1-benzopyran-2-one
Coumarin, 7-methoxy- (8CI)
MEGxp0_000150
DTXSID5060196
ACon1_002037
HY-N1366A
KBio1_001362
KBio2_000872
KBio2_003440
KBio2_006008
KBio3_001206
7-Methoxy-2H-chromen-2-one #
HMS2271N13
Herniarin;Methyl umbelliferyl ether
HY-N1366
BDBM50303499
CCG-38669
NSC404559
STK374268
ZB1865
7-Methoxycoumarin, analytical standard
AKOS000277129
FM52331
SDCCGMLS-0066524.P001
NCGC00095528-01
NCGC00095528-02
NCGC00095528-03
NCGC00095528-05
NCGC00179069-01
NCGC00179069-02
7-Methoxy-2H-1-benzopyran-2-one, 9CI
AC-34354
AS-58718
SY048641
CS-0016775
M1723
NS00022307
S5163
C09268
EN300-399800
7-Methoxycoumarin 100 microg/mL in Acetonitrile
A829418
SR-01000712094
Herniarin, primary pharmaceutical reference standard
Q3408685
SR-01000712094-2
BRD-K81209159-001-02-9
Z53852417
7-METHOXYCOUMARIN (CONSTITUENT OF CHAMOMILE) [DSC]
7-Methoxycoumarin, suitable for fluorescence, >=98.0% (TLC)