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7-Nitro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepine-3-carboxylic acid

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Identification
Molecular formula
C16H11N3O5
CAS number
89269-64-7
IUPAC name
7-nitro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepine-3-carboxylic acid
State
State

The compound is in a solid state at room temperature.

Melting point (Celsius)
215.00
Melting point (Kelvin)
488.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
309.32g/mol
Molar mass
359.3000g/mol
Density
1.4000g/cm3
Appearence

The compound typically appears as a yellow crystalline powder. It may be solid at room temperature, displaying a uniform texture with a slightly granular consistency that is typical of many organic compounds used in chemical syntheses.

Comment on solubility

Solubility of 7-nitro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepine-3-carboxylic acid

The solubility of 7-nitro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepine-3-carboxylic acid is influenced by a variety of factors, making it an interesting compound in the realm of chemical science. Here are some key points to consider:

  • Polarity: Given the presence of both a carboxylic acid group and a benzodiazepine structure, this compound exhibits polar characteristics which can affect its solubility in various solvents.
  • Solvent Compatibility: It tends to show better solubility in polar solvents such as water and ethanol compared to non-polar solvents. As a rule of thumb, “like dissolves like” is an important guideline to assess its solubility.
  • pH Dependence: The solubility may vary with pH; higher solubility is often observed at more acidic or more alkaline conditions due to the ionization of the carboxylic acid group.
  • Temperature Effects: Generally, increasing temperature can enhance solubility for many organic compounds; thus, heating the solvent might increase the solubility of this compound.

Researchers often state that "assessing solubility can provide insights into a compound's bioavailability and reactivity." Therefore, the solubility profile of 7-nitro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepine-3-carboxylic acid not only aids in understanding its transport within biological systems but can also inform its potential applications in medicinal chemistry.

Interesting facts

7-Nitro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepine-3-carboxylic acid

This intriguing compound belongs to the class of benzodiazepines, which are well-known for their psychoactive properties. Benzodiazepines are widely used in medicine, particularly for their anxiolytic, hypnotic, and muscle relaxant effects. The presence of a nitro group in this compound enhances its reactivity and biological activity, opening up avenues for further research.

Key Features:

  • Structure: Its unique molecular structure features a phenyl group, which contributes to its interaction with biological receptors.
  • Biological Significance: Compounds structurally related to this compound are often studied for their therapeutic potential, particularly in treating conditions such as anxiety and epilepsy.
  • Synthesis: The synthesis of this compound often involves multi-step reactions, showcasing the complexity of producing benzodiazepines and similar derivatives.
  • Research Potential: Ongoing studies aim to explore its effects on neurotransmitter systems, particularly GABAA receptors, which are crucial for inhibitory neurotransmission in the brain.

Quotes from leading researchers emphasize its importance: "Understanding the mechanisms of benzodiazepines can lead to better therapeutic agents with fewer side effects." In the world of medicinal chemistry, compounds such as 7-nitro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepine-3-carboxylic acid serve as critical points of exploration, driving innovation in pharmacology and therapeutic development. Given its potential, this compound not only represents a significant piece of the benzodiazepine puzzle but also a gateway to future discoveries in related fields.


Synonyms
60676-80-4
Nitrazepate
2,3-Dihydro-7-nitro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-3-carboxylic acid
7-nitro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepine-3-carboxylic acid
EINECS 262-372-2
UNII-1HPA15G63C
CHEMBL2110637
SCHEMBL11833501
DTXSID90863560
JPEUYYKTUFRADV-UHFFFAOYSA-N
DB-313045
NS00055649