Nitrazepam | Solubility of Things

Identification

Molecular formula

C₁₅H₁₁N₃O₃

CAS number

146-22-5

IUPAC name

7-nitro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one

State

At room temperature, Nitrazepam is a solid. It is stable under normal conditions but should be stored in a cool, dry place to maintain its efficacy and longevity.

Melting point (Celsius)

227.00

Melting point (Kelvin)

500.15

Boiling point (Celsius)

315.00

Boiling point (Kelvin)

588.15

General information

Molecular weight

281.27g/mol

Molar mass

281.2730g/mol

Density

1.4980g/cm³

Appearence

Nitrazepam appears as a crystalline solid. It is typically off-white to pale yellow in color, depending on the purity and specific formulation of the compound.

Comment on solubility

Solubility of 7-nitro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one

The solubility of 7-nitro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one (C₁₅H₁₁N₃O₃) can be characterized as follows:

Solvent Dependency: The compound exhibits varying solubility in different solvents. Generally, organic compounds like this benzodiazepine derivative tend to dissolve well in organic solvents but may show limited solubility in water.
Polarity Influence: Given its structure, the presence of a nitro group may enhance interactions with polar solvents, potentially leading to moderate solubility.
Hydrophobic Components: The aromatic phenyl ring contributes to hydrophobicity, further complicating the solubility profile in aqueous environments.

In most practical scenarios, it's noted that:

General Solubility: The compound is expected to be soluble in organic solutions such as ethanol, methanol, or dimethyl sulfoxide (DMSO).
Limited Aqueous Solubility: Water solubility is likely to be low, which is common for many benzodiazepine derivatives.
Temperature Effects: Solubility can also be influenced by temperature, with increased temperatures often enhancing solubility in non-polar solvents.

In conclusion, while 7-nitro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one demonstrates specific solubility characteristics dictated by its chemical structure, the behavior in various solvents highlights the complexity of predicting solubility purely based on molecular composition.

Interesting facts

Interesting Facts about 7-nitro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one

7-nitro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one, commonly known for its role in various chemical and biological applications, is a notable compound within the benzodiazepine family. Here are some intriguing aspects to consider:

Pharmacological Significance: Compounds in the benzodiazepine class are well-known for their anxiolytic, sedative, and muscle relaxant properties. Research into this specific compound may unveil potential therapeutic applications.
Synthetic Pathways: The synthesis of such compounds often involves intricate organic reactions, showcasing the creativity and complexity inherent in synthetic organic chemistry. Understanding the synthetic routes can provide insights into various reaction mechanisms.
Role of Nitro Groups: The presence of the nitro group in this compound enhances its electronic properties, which can significantly influence its biological activity. Nitro groups often serve as pharmacophores, contributing to the compound's overall reactivity.
Research Potential: Investigation into derivatives of this compound may lead to the discovery of new drugs with improved efficacy and reduced side effects. The exploration of structure-activity relationships is crucial in drug development.
Interdisciplinary Connections: The study of benzodiazepines like this one intersects fields such as medicinal chemistry, pharmacology, and toxicology, illustrating the compound's multifaceted relevance in science.

In summary, 7-nitro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one is not just a mere chemical structure; it embodies a wealth of possibilities waiting to be explored, making it an exciting subject for chemists and researchers alike.

Synonyms

nitrazepam

Benzalin

146-22-5

Mogadon

Neozepam

Imeson

Remnos

Eunoctin

Neuchlonic

Nitrados

Radedorm

Trazenin

Apodorm

Calsmin

Hipnax

Hipsal

Imesont

Nelmat

Sonebon

Surem

Epibenzalin

Epinelbon

Nitrenpax

Unisomnia

Dumolid

Paxisyn

Somitran

Sonnolin

Nelbon

Pelson

Relact

N-Desmethylnimetazepam

Persopit

Cerson

Gerson

Ibrovek

Eatan

Dormo-Puren

Nitrazepamum

Mitidin

Dormin-5

Eatan N

Somnite

1,3-Dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one

Ro 4-5360

Nitrazepamum [INN-Latin]

Ro 5-3059

Mogadone

Magadon

Megadon

Mogadan

Pacisyn

NSC-58775

7-Nitro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one

Dormicum (anticonvulsant)

LA 1

7-Nitro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one

7-nitro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one

Nitrazepam (TN)

Benzalin (TN)

2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-nitro-5-phenyl-

S 2000

Nitrazepam [USAN:INN:BAN:JAN]

CCRIS 1931

2,3-Dihydro-7-nitro-5-phenyl-1H-1,4-benzodiazepin-2-on

7-Nitro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one

EINECS 205-665-2

9CLV70W7HS

NSC 58775

BRN 0757185

CHEBI:7581

DTXSID5023372

N05CD02

NITRAZEPAM [MI]

NSC58775

NITRAZEPAM [INN]

NITRAZEPAM [JAN]

Nitrazadon

Nitrodiazepam

NITRAZEPAM [USAN]

Ro-45360

Ro-53059

NITRAZEPAM [MART.]

NITRAZEPAM [WHO-DD]

NITRAZEPAM [WHO-IP]

CHEMBL13209

RO-4-5360

RO-5-3059

DTXCID803372

2,3-dihydro-7-nitro-5-phenyl-1H-1,4-benzodiazepin-2-one

NITRAZEPAM [EP MONOGRAPH]

5-24-04-00344 (Beilstein Handbook Reference)

NITRAZEPAMUM [WHO-IP LATIN]

NCGC00159358-02

1, 3-Dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one

Calsamin

Eunoktin

Ipersed

Nitravet

Nitrempax

Noctesed

Somnased

Somnibel

Nitrazepamum (INN-Latin)

NITRAZEPAM (MART.)

LA 1 (VAN)

NITRAZEPAM (EP MONOGRAPH)

7-Nitro-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

Nitrazepam (100?g/ml in Acetonitrile)

CAS-146-22-5

Nitrazepam (1.0 mg/mL in Acetonitrile)

SMR000058302

UNII-9CLV70W7HS

Nitrosun

Ormodon

Paxadorm

Insoma

DEA No. 2834

ISOPROPYLACETATE/NITRAZEPAM

Ro 53-60

ChemDiv1_022312

Oprea1_476234

SCHEMBL35202

MLS001304053

MLS001424061

Nitrazepam (JP18/USAN/INN)

HMS650G04

KJONHKAYOJNZEC-UHFFFAOYSA-

HMS2051F19

HMS2272G03

HMS3393F19

7-Nitro-1,4-benzodiazepin-2-one

LFA76545

Nitrazepam, 1mg/ml in Acetonitrile

Tox21_111601

BDBM50020856

PDSP1_000120

PDSP2_000120

STK806322

AKOS002254707

Nitrazepam 0.1 mg/ml in Acetonitrile

Nitrazepam 1.0 mg/ml in Acetonitrile

Tox21_111601_1

WLN: T67 GMV JN IHJ CNW KR

AB02342

AC-4537

CCG-100977

DB01595

FN59698

NC00227

NCGC00159358-03

2H-1, 1,3-dihydro-7-nitro-5-phenyl-

7-Nitro-5-phenyl-2,4-benzodiazepin-2-one

DB-042832

NS00000041

C07487

D00531

A808471

Q410078

7-nitro-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one

Nitrazepam, British Pharmacopoeia (BP) Reference Standard

Nitrazepam, European Pharmacopoeia (EP) Reference Standard

(Z)-7-nitro-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one

1,3-Dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepine-2-one

7-Nitro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one #

205-665-2

InChI=1/C15H11N3O3/c19-14-9-16-15(10-4-2-1-3-5-10)12-8-11(18(20)21)6-7-13(12)17-14/h1-8H,9H2,(H,17,19)