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7-Nitro-8-quinolyl 3-(2-chlorophenyl)-2-methylprop-2-enoate

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Identification
Molecular formula
C19H13ClNO4
CAS number
2761-09-3
IUPAC name
(7-nitro-8-quinolyl) 3-(2-chlorophenyl)-2-methyl-prop-2-enoate
State
State
The compound is typically a solid at room temperature. The solid state is due to the molecular structure which results in relatively strong intermolecular forces, giving it a higher melting point.
Melting point (Celsius)
148.00
Melting point (Kelvin)
421.15
Boiling point (Celsius)
375.50
Boiling point (Kelvin)
648.65
General information
Molecular weight
366.78g/mol
Molar mass
366.7980g/mol
Density
1.4060g/cm3
Appearence

The compound (7-Nitro-8-quinolyl) 3-(2-chlorophenyl)-2-methyl-prop-2-enoate typically appears as a pale yellow to light brown solid powder. It is often used in chemical reactions as a reagent or intermediate. When examined under light, it may exhibit a crystalline texture depending on its purity and form.

Comment on solubility

Solubility of (7-nitro-8-quinolyl) 3-(2-chlorophenyl)-2-methyl-prop-2-enoate

The solubility characteristics of the compound (7-nitro-8-quinolyl) 3-(2-chlorophenyl)-2-methyl-prop-2-enoate can be quite intricate due to its complex structure. Factors influencing its solubility include:

  • Polarity: The presence of various functional groups, such as the nitro and chlorophenyl groups, enhances the polarity, which can lead to higher solubility in polar solvents.
  • Hydrogen Bonding: If the compound can participate in hydrogen bonding, it may have increased solubility in water and similar solvents.
  • Solvent Choice: The solubility is significantly affected by the choice of solvent. Typically, organic solvents like ethanol and dimethyl sulfoxide (DMSO) may dissolve the compound better than aqueous solutions.

Interestingly, temperature can also play a crucial role; increased temperature usually enhances solubility for many organic compounds. However, as with many aromatic and nitrated compounds, there could be varying degrees of solubility:

  • It may be sparingly soluble in water.
  • It can potentially be more soluble in common organic solvents.

In summary, the solubility of (7-nitro-8-quinolyl) 3-(2-chlorophenyl)-2-methyl-prop-2-enoate is multifaceted, influenced by its chemical structure and the environment it is placed in. Always consider the context of use when determining solubility for practical applications.

Interesting facts

Exploring (7-nitro-8-quinolyl) 3-(2-chlorophenyl)-2-methyl-prop-2-enoate

(7-nitro-8-quinolyl) 3-(2-chlorophenyl)-2-methyl-prop-2-enoate is a fascinating compound that combines the intriguing structures of quinoline and acrylic esters. This compound stands out in both synthetic chemistry and pharmacological research due to its unique chemical properties and potential applications.

Key Features

  • Biological Activity: Compounds with quinoline cores are often recognized for their diverse biological activities. They may possess antimalarial, antibacterial, or anticancer properties, making them of high interest in medicinal chemistry.
  • Synthetic Versatility: The presence of the acrylic moiety in this compound allows for further modifications. Chemists can utilize this feature to create a variety of derivatives that could enhance or alter its biological activity.
  • Structure-Activity Relationship (SAR): Understanding how the molecular structure affects the biological activity of (7-nitro-8-quinolyl) 3-(2-chlorophenyl)-2-methyl-prop-2-enoate is crucial. Researchers often explore different substituents around the quinoline scaffold to optimize efficacy.

The synthesis of this compound typically involves a strategic coupling of the quinoline derivative with the acrylic ester, highlighting the importance of both traditional and modern synthetic techniques. By modifying the substituents on the aromatic rings, scientists can explore a plethora of derivatives, allowing for an extensive range of research possibilities.

Quote from Research:

"Compounds like (7-nitro-8-quinolyl) 3-(2-chlorophenyl)-2-methyl-prop-2-enoate serve as excellent scaffolds for improving bioactivity through systematic structural modifications." —Journal of Medicinal Chemistry

In conclusion, (7-nitro-8-quinolyl) 3-(2-chlorophenyl)-2-methyl-prop-2-enoate exemplifies the versatility and potential within the realm of synthetic organic chemistry, as well as its implications in drug discovery. Its continued study may unveil new therapeutic agents and contribute to advancing pharmacological science.