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6-Thioguanine

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Identification
Molecular formula
C5H5N5S·H2O
CAS number
154-42-7
IUPAC name
7H-purine-6-thiol;hydrate
State
State

At room temperature, 6-Thioguanine exists as a solid in the form of a hydrate. This indicates that it contains water molecules within its crystalline structure.

Melting point (Celsius)
338.00
Melting point (Kelvin)
611.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
167.20g/mol
Molar mass
167.1980g/mol
Density
1.9000g/cm3
Appearence

6-Thioguanine is typically observed as a fine, crystalline powder with a characteristic pale yellow color. As a hydrate, it may also exhibit some moisture-retention properties, which can slightly alter its appearance under certain conditions.

Comment on solubility

Solubility of 7H-purine-6-thiol;hydrate

7H-purine-6-thiol;hydrate is a compound that exhibits intriguing solubility characteristics. Generally, the solubility of thiol compounds in water can be affected by various factors including:

  • Polar and Nonpolar Interactions: Thiols tend to have a polar –SH (sulfhydryl) group, which can interact with water.
  • Hydration Properties: The presence of water molecules in the hydrate form can enhance solubility due to increased hydrogen bonding.
  • Temperature: Solubility may increase with temperature, particularly in organic solvents.

For 7H-purine-6-thiol;hydrate, the general expectation is:

  • Enhanced solubility in polar solvents like water due to hydration effects.
  • Potential limited solubility in nonpolar solvents due to its structure.

As a result, it can often be stated that “the solubility of this compound in water makes it suitable for various biological applications”. Understanding its solubility behavior is essential for practical applications in pharmaceuticals and biochemistry.

Interesting facts

Interesting Facts about 7H-Purine-6-thiol Hydrate

7H-Purine-6-thiol is a fascinating compound belonging to the purine family, which is critical in biological systems. Here are some interesting aspects about this compound:

  • Biological Significance: Purines are essential building blocks of nucleic acids. They play a vital role in the storage and transfer of genetic information through molecules like DNA and RNA.
  • Structure and Function: The unique structure of 7H-purine-6-thiol includes a thiol functional group (–SH), which can participate in various biochemical reactions, influencing protein structure and function.
  • Metabolic Role: This compound is part of various metabolic pathways, including the synthesis of nucleotides, which are necessary for cell division and energy transfer via ATP (adenosine triphosphate).
  • Potential Therapeutic Applications: Compounds like 7H-purine-6-thiol may have therapeutic implications in treating certain diseases by modulating nucleic acid metabolism, offering potential in anti-cancer and anti-viral therapies.
  • Research Interest: Ongoing studies focus on the role of thiol groups in redox biology, leading to insights about cellular environments and oxidative stress.

As noted by researchers, "Understanding the diverse roles of purines and their derivatives is crucial for navigating the complexities of cellular functions and disease mechanisms."
This emphasizes the importance of compounds like 7H-purine-6-thiol in both fundamental research and applied sciences.

In summary, 7H-purine-6-thiol hydrate serves as a notable example of how a simple molecular change can lead to profound biological implications. Its exploration opens doors to new discoveries in biochemistry and pharmacology.