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Lorlatinib

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Identification
Molecular formula
C21H19ClN6O3
CAS number
1454846-35-5
IUPAC name
[(7R,8S)-11-amino-5-(2-chlorobenzoyl)-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate
State
State

At room temperature, Lorlatinib is a solid.

Melting point (Celsius)
183.00
Melting point (Kelvin)
456.00
Boiling point (Celsius)
308.00
Boiling point (Kelvin)
581.00
General information
Molecular weight
406.86g/mol
Molar mass
406.4790g/mol
Density
1.3000g/cm3
Appearence

Lorlatinib typically appears as a white to off-white, amorphous or crystalline powder.

Comment on solubility

Solubility of [(7R,8S)-11-amino-5-(2-chlorobenzoyl)-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate

The solubility of the compound [(7R,8S)-11-amino-5-(2-chlorobenzoyl)-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate can be influenced by several key factors:

  • Polarity: The presence of the amino group and carbamate functionality often indicates solubility in polar solvents, such as water.
  • Substituents: The 2-chlorobenzoyl and methoxy groups may affect the overall polarity, potentially reducing aqueous solubility due to hydrophobic interactions.
  • pH Sensitivity: The solubility may vary depending on pH, especially due to the amino group, which can be protonated or deprotonated, impacting solubility in different environments.
  • Temperature Effects: Increased temperature may enhance solubility, particularly for compounds with significant hydrophobic characteristics.

In general, the solubility characteristics of such complex organic molecules can lead to unpredictable behaviors in aqueous environments. It is encouraging to conduct empirical solubility tests to determine the most accurate solubility profile, taking into account the interaction of the compound with solvents and surrounding functional groups.

Interesting facts

Interesting Facts about [(7R,8S)-11-amino-5-(2-chlorobenzoyl)-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate

This complex chemical compound belongs to a unique class of synthetic organic compounds that has captured the interest of researchers and scientists alike due to its intriguing structure and potential applications. Here are some fascinating insights:

  • Structural Diversity: The presence of a tetracyclic structure in this compound enhances its molecular diversity, making it an excellent candidate for various chemical reactions and biological interactions.
  • Pharmacological Potential: Compounds like this often display a range of bioactivities, which may include antimicrobial, anticancer, or anti-inflammatory properties. Researchers are actively exploring its therapeutic effects.
  • Chirality and Stereochemistry: The specific stereochemistry of this compound, indicated by its (7R,8S) configuration, implies that it may exhibit different biological activities based on its orientation. This aspect is crucial in drug design, as stereoisomers can have vastly different properties.
  • Functional Groups: The presence of amino and methoxy functional groups contributes to the compound's potential interactions with biological systems, influencing solubility and reactivity.
  • Research Significance: Due in part to its unique scaffold, this compound might serve as a lead compound for the development of new drugs, making it a focal point for medicinal chemistry studies.

In conclusion, the intriguing structure and potential applications of this compound highlight the vast possibilities within organic chemistry and pharmacology. As scientists continue to unravel the intricate chemistry behind such compounds, we may uncover new pathways for therapeutic discovery.

Synonyms
BRN 0871109
16962-75-7
Azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione, 1,1a,2,8,8a,8b-hexahydro-6-amino-1-(o-chlorobenzoyl)-8-(hydroxymethyl)-8a-methoxy-5-methyl-, carbamate
DTXSID50937655
[6-Amino-1-(2-chlorobenzoyl)-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl]methyl hydrogen carbonimidate