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Ertapenem

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Identification
Molecular formula
C22H25N3O7
CAS number
153832-46-3
IUPAC name
[(7R,8S)-11-amino-7-methoxy-12-methyl-10,13-dioxo-5-pentanoyl-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate
State
State

Ertapenem is typically found in a solid state as a dry powder that is reconstituted for parenteral administration.

Melting point (Celsius)
147.00
Melting point (Kelvin)
420.20
Boiling point (Celsius)
196.70
Boiling point (Kelvin)
469.90
General information
Molecular weight
476.53g/mol
Molar mass
476.5290g/mol
Density
1.5000g/cm3
Appearence

Ertapenem appears as a white to off-white powder. It is very hygroscopic and is supplied as a sodium salt for injections.

Comment on solubility

Solubility Characteristics

The compound [(7R,8S)-11-amino-7-methoxy-12-methyl-10,13-dioxo-5-pentanoyl-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate exhibits unique solubility properties that can be explored further. Understanding its solubility is crucial for applications in pharmaceuticals, where the efficacy of the compound may depend significantly on its ability to dissolve in various solvents.

Key Factors Influencing Solubility

  • Polarity: The presence of functional groups such as amino and methoxy can impact the polarity of the molecule, influencing its solubility in polar or non-polar solvents.
  • Intermolecular Interactions: Hydrogen bonding potential may enhance solubility in aqueous media, while hydrophobic interactions may favor solubility in organic solvents.
  • pH Sensitivity: The ionization state of the amino group can vary with pH, potentially altering solubility in different pH environments.

In general, compounds with similar functional groups tend to display certain trends in solubility:

  1. **Ammonium salts** are often soluble in water.
  2. **Esters** and **ethers** may exhibit variable solubility, often depending on their molecular weight.
  3. **Complex structures** may show limited solubility, necessitating careful solvent selection for applications.

As a conclusion, determining the solubility profile of this compound can provide valuable insights for its practical applications, emphasizing the importance of conducting thorough solubility studies. Such knowledge will aid in optimizing formulations and enhancing the compound's usefulness in various fields.

Interesting facts

Interesting Facts about [(7R,8S)-11-amino-7-methoxy-12-methyl-10,13-dioxo-5-pentanoyl-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate

This intriguing compound belongs to a class of chemical structures known for their complex frameworks and diverse biological activities. Here are some notable points regarding its characteristics and significance:

  • Structural Complexity: The compound features a unique tetracyclic structure, which can often lead to interesting three-dimensional conformations that may significantly influence its reactivity and interactions with biological systems.
  • Biological Relevance: Many compounds with similar structures are studied for their potential therapeutic properties. They might exhibit activities including antimicrobial, antifungal, and anticancer properties, making them attractive candidates for pharmaceutical development.
  • Mechanisms of Action: Due to its amino and dioxo functional groups, the compound may interact with specific biological targets, potentially affecting metabolic pathways or inhibiting enzyme functionality, which is crucial in drug discovery.
  • Synthetic Challenges: The synthesis of such complex molecules often presents a variety of challenges, including control over stereochemistry and functional group transformations. This complexity is a rich area for research in synthetic organic chemistry.
  • Potential Applications: With continued research, compounds like this have the potential to be developed into drugs or agrochemicals, highlighting the importance of academic and industrial collaborations.

In summary, the compound's intricate structure and potential biological implications make it a fascinating subject for ongoing scientific investigation. Its ability to serve various purposes underscores the importance of studying complex molecules in greater detail to uncover their full potential in science and medicine.

Synonyms
DTXSID10937590
(6-Amino-8a-methoxy-5-methyl-4,7-dioxo-1-pentanoyl-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl)methyl hydrogen carbonimidate