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Irinotecan

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Identification
Molecular formula
C33H38N4O6
CAS number
97682-44-5
IUPAC name
[(7R,8S)-11-(butylamino)-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate
State
State
Irinotecan is typically found as a crystalline solid at room temperature. It is often handled in a dry, powdered form for ease of storage and use in pharmaceutical formulations, especially as an injectable form for medical therapies.
Melting point (Celsius)
256.50
Melting point (Kelvin)
529.65
Boiling point (Celsius)
265.00
Boiling point (Kelvin)
538.00
General information
Molecular weight
586.68g/mol
Molar mass
586.6780g/mol
Density
1.5280g/cm3
Appearence
Irinotecan typically appears as a pale yellow to yellow crystalline powder. Its appearance is consistent with many pharmaceutical compounds and is used primarily in medical applications.
Comment on solubility

Solubility of [(7R,8S)-11-(butylamino)-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate

The solubility of the compound [(7R,8S)-11-(butylamino)-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate is influenced by a variety of factors, including its molecular structure and functional groups. Here are some key considerations:

  • Polarity: The presence of polar functional groups such as the carbamate may enhance solubility in polar solvents, such as water.
  • Hydrophobic regions: The butylamino group contributes a hydrophobic aspect, which could limit solubility in water but increase solubility in organic solvents.
  • Temperature: Solubility can also be affected by temperature, with many compounds becoming more soluble at elevated temperatures.
  • pH levels: The compound's solubility might vary with changes in pH, particularly due to potential ionization of the functional groups.

In general, for complex organic compounds like this, predicting solubility entails considering both the micro-level interactions and the environmental context. It is often stated, “like dissolves like,” reinforcing the notion that compounds will show greater solubility in solvents with similar polarities. Thus, solubility studies are essential for any practical applications involving this compound.

Interesting facts

Fascinating Insights into [(7R,8S)-11-(butylamino)-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate

This compound intrigues scientists and researchers due to its complex structure and potential applications in various fields. Here are some noteworthy facts:

  • Unique Structure: The compound belongs to a class of chemicals known as tetracyclic compounds, which are recognized for their intricate arrangements and distinctive properties.
  • Biological Significance: Tetracyclic compounds often exhibit a range of biological activities. This specific compound has garnered attention for its potential in pharmacology and medicinal chemistry, where it may serve roles in drug development.
  • Functional Groups: The presence of various functional groups, such as butylamino and methoxy, implies diverse interactions within biological systems. These functionalities can affect the compound's solubility, reactivity, and overall efficacy.
  • Stereochemistry: The specified stereochemistry (7R, 8S) is crucial. Stereocenters can significantly influence a compound's biological effects, making stereochemical considerations essential in the development of pharmaceuticals.
  • Natural Product Chemistry: Many compounds with similar frameworks are derived from natural sources, inspiring synthetic chemists to explore this compound's origin and its analogs in nature.

As research progresses, the compound's unique attributes may lead to innovative applications in medicine and beyond, allowing scientists to harness its properties in ways that could benefit society.

Ultimately, compounds like this one remind us of the beautiful complexity found in chemistry, merging creativity with precision to expand our understanding of the molecular world.

Synonyms
BRN 1182835
NSC 134716
Azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione, 1,1a,2,8,8a,8b-hexahydro-6-(butylamino)-8-(hydroxymethyl)-8a-methoxy-5-methyl-, carbamate (ester)
14769-01-8