Skip to main content

Doxorubicin

ADVERTISEMENT
Identification
Molecular formula
C27H29N1O11
CAS number
23214-92-8
IUPAC name
[(7R,8S)-7-hydroxy-5,12-dimethyl-11-(methylamino)-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate
State
State

Doxorubicin is typically a solid at room temperature. It is usually handled as a powder or in the form of its hydrochloride salt for medical and research purposes.

Melting point (Celsius)
205.00
Melting point (Kelvin)
478.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
543.52g/mol
Molar mass
543.5240g/mol
Density
1.6009g/cm3
Appearence

Doxorubicin is an orange-red, crystalline powder. It is known for its intense coloration, which is due to its chromophore structure, allowing the compound to absorb visible light efficiently. This distinctive color is characteristic of anthracycline antibiotics.

Comment on solubility

Solubility Overview

The compound [(7R,8S)-7-hydroxy-5,12-dimethyl-11-(methylamino)-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate exhibits interesting solubility characteristics that can be influenced by several factors. Understanding its solubility is crucial for applications in pharmaceutical formulations and chemical synthesis.


Key Solubility Characteristics

  • Polar vs. Nonpolar Solvents: The presence of functional groups such as hydroxyl and carbamate suggests that this compound may be more soluble in polar solvents like water, while potentially showing lower solubility in nonpolar environments.
  • Temperature Dependence: Solubility can vary with temperature. As temperature increases, compounds often dissolve better due to enhanced molecular motion.
  • pH Dependence: Since the compound contains an amino group, its solubility may be affected by the pH of the solution, as it could become protonated or deprotonated.

In summary, while this compound possesses certain features that could enhance its solubility in specific contexts, the overall solubility behavior will ultimately depend on environmental conditions and the chosen solvent. As the adage goes, "like dissolves like," emphasizing the importance of matching polarities when predicting solubility outcomes.

Interesting facts

Interesting Facts about [(7R,8S)-7-hydroxy-5,12-dimethyl-11-(methylamino)-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate

This complex compound, often referred to by its systematic name, belongs to a class of chemicals known for their unique structural arrangements and biological activities. Here are some intriguing insights:

  • Structural Intricacy: The compound's tetracyclic backbone indicates a highly complex molecular architecture, which contributes to its potential activity in various biochemical pathways.
  • Biological Relevance: With multiple functional groups, particularly the hydroxyl and amino substituents, it may exhibit intriguing interactions with biological macromolecules, which could be valuable in drug design.
  • Potential Applications: Due to its diverse functional groups, this compound could serve as a template for the development of therapeutics aimed at a range of conditions, perhaps particularly in the realm of cancer or neurological disorders.
  • Synthetic Challenges: The synthesis of such a multi-faceted structure often requires sophisticated methodologies, including multi-step reactions and careful stereochemical control to achieve the desired chirality.
  • Avenue for Research: The exploration of this compound can pave the way for developing novel scaffolds in medicinal chemistry, possibly leading to new discoveries in pharmacology.

In conclusion, the compound's intricate structure and functional diversity position it as a promising candidate for further scientific exploration. As chemists continue to unveil the potential applications, this compound could play a vital role in advancing pharmaceutical research and development.