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Vinblastine

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Identification
Molecular formula
C46H58N4O9
CAS number
865-21-4
IUPAC name
[(7R,8S)-7-methoxy-12-methyl-10,13-dioxo-11-(pentylamino)-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate
State
State

At room temperature, vinblastine is typically found in solid form as a crystalline powder. When used for therapeutic purposes, it is often processed into a liquid injectable form.

Melting point (Celsius)
267.00
Melting point (Kelvin)
540.00
Boiling point (Celsius)
260.00
Boiling point (Kelvin)
533.00
General information
Molecular weight
909.04g/mol
Molar mass
909.0430g/mol
Density
1.3000g/cm3
Appearence

Vinblastine is typically provided as a white to off-white crystalline powder. Due to its use in pharmaceutical formulations, it is often found in the form of injections where it is presented as a clear solution.

Comment on solubility

Solubility of [(7R,8S)-7-methoxy-12-methyl-10,13-dioxo-11-(pentylamino)-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate

The solubility of the compound (7R,8S)-7-methoxy-12-methyl-10,13-dioxo-11-(pentylamino)-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl methyl carbamate can be quite intricate, influenced by various factors. The presence of both polar (e.g., the carbamate group) and non-polar (e.g., pentyl chain) fragments within its structure suggests that its solubility characteristics may vary significantly in different solvents.

Key Factors Affecting Solubility:

  • Polarity: The structure contains functional groups that can engage in hydrogen bonding, enhancing solubility in polar solvents like water.
  • Hydrophobic Regions: The pentyl group may resist solvation in polar environments, which could limit solubility in aqueous solutions.
  • Temperature: Increasing temperature typically increases solubility for many compounds; however, it's important to consider thermal stability.
  • pH Levels: The carbamate functionality might behave differently under varying pH conditions, influencing its solubility profile.

In summary, while the intricate balance of its functional groups offers potential for solubility in various environments, the presence of non-polar segments may hinder its overall solubility in entirely polar solvents. Understanding the solubility behavior of this compound is crucial for its application in both pharmaceutical formulations and chemical processes.

Interesting facts

Interesting Facts about [(7R,8S)-7-methoxy-12-methyl-10,13-dioxo-11-(pentylamino)-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate

This intricate compound boasts a highly complex molecular structure, showcasing the fascinating interplay between chemistry and nature. Here's what makes it stand out:

  • Versatile Applications: Compounds like this one often exhibit potential in fields such as pharmaceuticals and agrochemicals. They might serve as crucial intermediates in developing new medications or crop protection agents.
  • Stereochemistry: The designation of (7R,8S) indicates the compound's chiral centers, revealing how stereochemistry plays a critical role in biochemical activity and interaction with biological systems. This is pivotal when considering the *enantiomeric effects* on drug efficacy and safety.
  • Diversity in Structure: The tetracyclic framework of the compound presents a rare opportunity for the research community to explore unique conformations and reactivity, contributing to our broader understanding of complex organic compounds.
  • Mechanism of Action: While specific mechanisms are still under investigation, compounds with similar structures can exhibit various biological activities, from enzyme inhibition to receptor modulation, making it a target of interest in medicinal chemistry.
  • Research Potential: The compound's unusual configuration makes it a suitable candidate for further studies, potentially leading to discoveries of novel therapeutic pathways or enhanced agricultural practices.

As a scientist or chemistry student, delving into the complexities of such compounds fosters a deeper appreciation for the intricate tapestry of chemistry. Each compound not only contributes to the scientific literature but also inspires innovative approaches toward solving real-world problems.

Synonyms
DTXSID40933186
[8a-Methoxy-5-methyl-4,7-dioxo-6-(pentylamino)-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl]methyl hydrogen carbonimidate