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Daptomycin

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Identification
Molecular formula
C72H101N17O26
CAS number
103060-53-3
IUPAC name
[(7R,8S)-7-methoxy-12-methyl-10,13-dioxo-11-(propylamino)-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate
State
State

At room temperature, Daptomycin is in a solid state. It is provided as a lyophilized powder for intravenous injection after reconstitution.

Melting point (Celsius)
145.00
Melting point (Kelvin)
418.00
Boiling point (Celsius)
278.00
Boiling point (Kelvin)
551.00
General information
Molecular weight
1620.67g/mol
Molar mass
1 620.6700g/mol
Density
1.3000g/cm3
Appearence

Daptomycin appears as a pale yellow to light brown, amorphous powder. It is typically used in its crystalline powder form.

Comment on solubility

Solubility of [(7R,8S)-7-methoxy-12-methyl-10,13-dioxo-11-(propylamino)-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate

The solubility of this complex compound is influenced by several factors including its molecular structure and polarity. Understanding its solubility can provide insights into its potential applications and behavior in different environments. Here are some key points to consider:

  • Polarity: The presence of functional groups, particularly the methoxy (–OCH3) and carbamate (–NHCOO-) functionalities, contributes to the overall polarity of the molecule. Generally, polar compounds tend to have higher solubility in polar solvents, such as water.
  • Hydrogen Bonding: The ability of this compound to form hydrogen bonds enhances its interactions with solvents. Compounds capable of hydrogen bonding often exhibit better solubility in polar solvents.
  • Methods of Testing: To accurately determine the solubility, various methods such as equilibrium solubility tests or dynamic solubility assessments can be employed. These methods can reveal how the compound behaves in different solvent systems.
  • Prediction and Applications: The solubility data is essential for drug formulation and development, where solubility influences factors like bioavailability and therapeutic effectiveness. The solubility predictions may help guide the synthesis and application of this compound in pharmaceutical contexts.

In summary, the solubility of [(7R,8S)-7-methoxy-12-methyl-10,13-dioxo-11-(propylamino)-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate may vary significantly depending on the medium and conditions. Understanding these characteristics is vital for harnessing the full potential of this chemical compound.

Interesting facts

Exploring the Unique Compound: Carbamate Derivative

The compound with the complex name (7R,8S)-7-methoxy-12-methyl-10,13-dioxo-11-(propylamino)-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl methyl carbamate is a fascinating entry in the realm of organic chemistry. Its intricate structure and functional groups provide a glimpse into the potential therapeutic roles that such compounds may play in medicinal chemistry.

Key Features and Insights

  • Tetracyclic Framework: The compound is characterized by a complex tetracyclic structure, which is integral to its biological activity. This arrangement can enhance interaction with biological targets, making it a candidate for drug development.
  • Functional Groups: With multiple functional groups, including methoxy, dioxo, and carbamate, this compound showcases a diverse array of chemical reactivity, contributing to its versatility.
  • Potential Therapeutic Applications: Compounds with such intricate structures often display significant pharmacological properties, including anti-inflammatory and antimicrobial effects. Research into similar structures has yielded compounds employed for treating various diseases.
  • Stereochemistry: The specific stereochemical configuration (7R, 8S) is crucial for the biological activity of the compound. Stereochemistry influences how molecules interact with enzymes and receptors in the body.
  • Research Interest: Ongoing research into carbamate derivatives emphasizes their potential as inhibitors for specific enzymes, showcasing a vibrant area of inquiry in medicinal chemistry.

As scientists continue to unravel the complexities of structures like this one, the implications for drug discovery and design remain immense. These compounds exemplify the interplay between intricate structure and biological function, paving the way for innovative solutions in pharmacotherapy.

Synonyms
DTXSID80936277
16032-94-3
[8a-Methoxy-5-methyl-4,7-dioxo-6-(propylamino)-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl]methyl hydrogen carbonimidate