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Colchicine

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Identification
Molecular formula
C22H25NO6
CAS number
64-86-8
IUPAC name
[(7R,8S)-7-methoxy-12-methyl-11-(methylamino)-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate
State
State

Colchicine is typically found as a solid at room temperature.

Melting point (Celsius)
157.00
Melting point (Kelvin)
430.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
399.44g/mol
Molar mass
399.4360g/mol
Density
1.2200g/cm3
Appearence

Colchicine is a white to pale yellow crystalline powder.

Comment on solubility

Solubility of [(7R,8S)-7-methoxy-12-methyl-11-(methylamino)-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate

The solubility of the compound [(7R,8S)-7-methoxy-12-methyl-11-(methylamino)-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate is influenced by several factors:

  • Polarity: Given its complex structure, including multiple functional groups like methoxy (-OCH3) and carbamate (-NCO2), the compound exhibits varying degrees of polarity. This can affect its solubility in different solvents.
  • Solvent Type: The solubility profile may change depending on whether the solvent is polar or nonpolar. Typically, polar solvents such as water may dissolve more polar compounds better.
  • Presence of Functional Groups: The structural elements of the compound can lead to hydrogen bonding, enhancing its solubility in polar solvents.
  • Concentration: As with many compounds, the solubility can vary with concentration. Higher concentrations might lead to precipitation.

In summary, while the solubility can be characterized as variable, it is essential to consider these influencing factors to predict the compound's behavior in solution effectively. This nuanced understanding is critical for practical applications, such as drug formulation and chemical synthesis.

Interesting facts

Interesting Facts about [(7R,8S)-7-methoxy-12-methyl-11-(methylamino)-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate

This compound, known for its complex structure and unique functional groups, belongs to a fascinating class of chemicals that showcase the intricate nature of organic chemistry. Here are some noteworthy points:

  • Structure Complexity: The tetracyclic framework of this compound allows for diverse interactions, potentially influencing its biological activity. Chemists are often intrigued by how such structures can exhibit myriad pharmacological properties.
  • Biological Relevance: Compounds featuring modifications like a methylamino group and carbamate moiety are often explored in medicinal chemistry for their potential therapeutic effects, particularly as enzyme inhibitors or in drug design.
  • Synthetic Pathways: The synthesis of such a complex organic molecule often involves multiple reaction steps, drawing on techniques such as coupling reactions, functional group transformations, and possibly even ring closures. This poses a fascinating challenge for synthetic chemists!
  • Chirality: The specification of (7R,8S) indicates that this compound has chiral centers. The presence of chirality in molecules significantly affects how they interact with biological systems, making the study of their optically active forms essential.

In essence, this compound serves as a prime example of the rich and diverse chemistry that characterizes the field. It embodies the *endless possibilities* presented by organic synthesis and the continuous quest for new compounds in medicinal chemistry. As one scientist put it, "Chemistry is not just a science; it is an art that shapes the very fabric of our existence." Keep exploring, as every compound has a story to tell!