Skip to main content

Norethisterone

ADVERTISEMENT
Identification
Molecular formula
C20H26O2
CAS number
68-22-4
IUPAC name
(7R,9S,14S,17R)-17-ethynyl-17-hydroxy-7,13-dimethyl-1,2,4,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
State
State

At room temperature, norethisterone is in the solid state, appearing as a crystalline powder.

Melting point (Celsius)
203.00
Melting point (Kelvin)
476.00
Boiling point (Celsius)
487.90
Boiling point (Kelvin)
761.10
General information
Molecular weight
298.43g/mol
Molar mass
298.4300g/mol
Density
1.2000g/cm3
Appearence

Norethisterone is typically a white to off-white crystalline powder. It is odorless or may have a faint characteristic odor.

Comment on solubility

Solubility of (7R,9S,14S,17R)-17-ethynyl-17-hydroxy-7,13-dimethyl-1,2,4,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one

The solubility of this complex organic compound can be influenced by several key factors, including polarity, molecular structure, and the presence of functional groups. For this particular compound, we can anticipate the following:

  • Polarity: The presence of hydroxyl (–OH) and ethynyl (–C≡C–) groups may contribute to its polarity, which typically increases solubility in polar solvents such as water and alcohol.
  • Hydrophobic regions: The extensive dodecahydrocyclopenta[a]phenanthrene structure likely contains significant hydrocarbon character, which could lead to limited solubility in highly polar solvents, preferring nonpolar or weakly polar solvents instead.
  • Solvent interactions: This compound may exhibit favorable interactions with solvents that can hydrogen bond or interact with its functional groups—making solvents like ethanol or acetone potential candidates.

Overall, it can be suggested that while the compound may have some solubility in polar solvents, its large hydrophobic character is likely to render it less soluble in water. As such, “like dissolves like” becomes an important principle to consider when evaluating its solubility in various applications.

Further empirical data should be utilized to provide precise solubility values in different solvents and under varied conditions.

Interesting facts

Interesting Facts about (7R,9S,14S,17R)-17-ethynyl-17-hydroxy-7,13-dimethyl-1,2,4,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one

This compound is a fascinating example of a synthetic steroid, often used in the realm of biochemistry and pharmacology. Here are some intriguing facts about it:

  • Structure Complexity: The compound's intricate structure includes multiple chiral centers and a unique cyclopenta[a]phenanthrene framework, which is rare and contributes to its biological activity.
  • Significance in Medicine: Compounds similar to this one are often researched for their potential therapeutic effects, including hormone replacement and anti-inflammatory properties.
  • Mechanism of Action: Steroidal compounds like this can interact with steroid hormone receptors, which mediate various physiological processes including metabolism, immune function, and reproductive health.
  • Synthesis Routes: The synthesis of such complex molecules presents significant challenges. It often involves multi-step organic synthesis, utilizing strategies such as stereochemistry and functional group transformations.
  • Regulatory Considerations: Due to their hormonal nature, research on this compound must navigate various regulatory frameworks, particularly when considering its use in human health.

As noted by experts in the field, “The ability to modify steroids at specific positions can lead to compounds with enhanced activity or reduced side effects.” This highlights the importance of understanding structure-activity relationships in drug development.

In summary, the study of (7R,9S,14S,17R)-17-ethynyl-17-hydroxy-7,13-dimethyl-1,2,4,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one not only enriches our understanding of steroid chemistry but also opens doors to advancements in pharmaceutical applications.