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Colchicine

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Identification
Molecular formula
C22H25NO6S
CAS number
64-86-8
IUPAC name
(7S)-7-amino-1,2,3-trimethoxy-10-methylsulfanyl-6,7-dihydro-5H-benzo[a]heptalen-9-one
State
State

Colchicine is in a solid state at room temperature, often in the form of crystals or crystalline powder.

Melting point (Celsius)
157.00
Melting point (Kelvin)
430.15
Boiling point (Celsius)
455.20
Boiling point (Kelvin)
728.35
General information
Molecular weight
399.44g/mol
Molar mass
399.4370g/mol
Density
1.5400g/cm3
Appearence

Colchicine is typically found as a pale yellow, crystalline powder.

Comment on solubility

Solubility of (7S)-7-amino-1,2,3-trimethoxy-10-methylsulfanyl-6,7-dihydro-5H-benzo[a]heptalen-9-one

The solubility of (7S)-7-amino-1,2,3-trimethoxy-10-methylsulfanyl-6,7-dihydro-5H-benzo[a]heptalen-9-one is influenced by several factors due to its complex structure. Understanding its solubility is crucial for various applications, especially in pharmacology and chemical synthesis.

  • Polarity: The presence of multiple methoxy groups contributes to a relatively polar character, which may enhance solubility in polar solvents such as water and methanol.
  • Functional Groups: The amino and methylsulfanyl groups could also facilitate interactions with solvents, potentially affecting the overall solubility.
  • Hydrophobicity: On the other hand, the benzo[a]heptalen core may introduce hydrophobic characteristics, which can limit solubility in aqueous solutions.

Overall, one can anticipate a moderate solubility behavior for this compound across different solvents:

  1. Soluble in polar solvents.
  2. Less soluble in non-polar solvents.

To effectively explore the solubility of (7S)-7-amino-1,2,3-trimethoxy-10-methylsulfanyl-6,7-dihydro-5H-benzo[a]heptalen-9-one, it is advised to perform solubility tests under various conditions to determine optimal solvent choices.

Interesting facts

Interesting Facts about (7S)-7-amino-1,2,3-trimethoxy-10-methylsulfanyl-6,7-dihydro-5H-benzo[a]heptalen-9-one

(7S)-7-amino-1,2,3-trimethoxy-10-methylsulfanyl-6,7-dihydro-5H-benzo heptalen-9-one is a fascinating compound that captures the interest of chemists due to its complex structure and potential applications. Here are some points that make this compound stand out:

  • Chiral Center: The designation of (7S) indicates a chiral center, which is crucial in the study of stereochemistry. Chirality can influence the biological activity of compounds, leading to differing effects based on their orientation.
  • Sulfur Substitution: The presence of a methylsulfanyl group adds a unique dimension to the compound, as sulfur tends to enhance reactivity and can influence the compound’s interaction with biological systems.
  • Trimethoxy Functional Groups: With three methoxy groups, this compound exhibits significant electron-donating ability, which can enhance its reactivity and stability in various chemical environments.
  • Potential Bioactivity: Compounds with complex structures, such as (7S)-7-amino-1,2,3-trimethoxy-10-methylsulfanyl-6,7-dihydro-5H-benzo heptalen-9-one, could potentially display interesting bioactivity, making it a candidate for pharmaceutical exploration.

This compound also exemplifies the beauty of organic synthesis where intricate structures can lead to important discoveries in medicinal chemistry, agriculture, and even materials science. The study of (7S)-7-amino-1,2,3-trimethoxy-10-methylsulfanyl-6,7-dihydro-5H-benzo heptalen-9-one offers a glimpse into the complexity and diversity of chemical compounds that continue to inspire scientific research.

Synonyms
N-Deacetylthiocolchicine
2731-16-0
Thiolcolciran
COLCHICINE, N-DEACETYL-10-THIO-
N-Desacetylthiocolchicine
Corps R. 261
N-Deacetylmethylthiocolchicine
Deacetylthiocolchicine
Desacetyl thiocolchicine
Colchicine, N-deacetyl-thio-
N-Desacetyl thiocolchicine
NSC 9170
BRN 2822164
R 261
Benzo(a)heptalen-9(5H)-one, 7-amino-6,7-dihydro-1,2,3-trimethoxy-10-(methylthio)-, (S)-
N-Deacetyl-10-demethoxy-10-methylthiocolchicine
Colchicine, N-deacetyl-10-demethoxy-10-methylthio-
DTXSID90181756
(7S)-7-Amino-6,7-dihydro-1,2,3-trimethoxy-10-(methylthio)benzo(a)heptalen-9(5H)-one
(7S)-7-Amino-6,7-dihydro-1,2,3-trimethoxy-10-(methylthio)benzo[a]heptalen-9(5H)-one
DTXCID30104247
630-576-4
Benzo(a)heptalen-9(5H)-one, 7-amino-6,7-dihydro-1,2,3-trimethoxy-10-(methylthio)-, (S)-(9CI)
Thio-colciran
Thiocolciran
NSC9170
(7S)-7-amino-1,2,3-trimethoxy-10-methylsulfanyl-6,7-dihydro-5H-benzo[a]heptalen-9-one
CHEMBL298240
(S)-7-Amino-1,2,3-trimethoxy-10-(methylthio)-6,7-dihydrobenzo[a]heptalen-9(5H)-one
MLS002702975
N-desacetyl-thiocolchicine
N-Deacetyl-10-thiocolchicine
cid_426728
SCHEMBL5434553
PKH 147
NUNCOHUMTCDISK-AWEZNQCLSA-N
NSC-9170
BDBM50014875
AKOS040751238
NCI60_042026
PD119243
CS-0104812
D76467
WLN: L B677 MV&T&J CO1 DO1 EO1 JZ NS1
(S)-7-Amino-1,2,3-trimethoxy-10-methylsulfanyl-6,7-dihydro-5H-benzo[a]heptalen-9-one
7-Amino-1,2,3-trimethoxy-10-methylsulfanyl-6,7-dihydro-5H-benzo[a]heptalen-9-one
Benzo[a]heptalen-9(5H)-one, 7-amino-6,7-dihydro-1,2,3-trimethoxy-10-(methylthio)-, (7S)-