Skip to main content

Colchicine Tartrate

ADVERTISEMENT
Identification
Molecular formula
C22H25NO6 · C4H6O6
CAS number
64-86-8; 87-69-4 for L-tartaric acid
IUPAC name
(7S)-7-amino-1,2,3,10-tetramethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one;2,3-dihydroxybutanedioic acid
State
State

Colchicine tartrate is in a solid state at room temperature, typically appearing as a fine, crystalline powder.

Melting point (Celsius)
153.00
Melting point (Kelvin)
426.15
Boiling point (Celsius)
346.00
Boiling point (Kelvin)
619.15
General information
Molecular weight
600.66g/mol
Molar mass
600.6600g/mol
Density
1.6600g/cm3
Appearence

Colchicine tartrate is typically a fine, crystalline powder. It is white to off-white in color and may appear as a lump-free, powdery substance when viewed closely.

Comment on solubility

Solubility of (7S)-7-amino-1,2,3,10-tetramethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one; 2,3-dihydroxybutanedioic acid

The solubility of the compound (7S)-7-amino-1,2,3,10-tetramethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one; 2,3-dihydroxybutanedioic acid can be quite intriguing due to the presence of both hydrophobic and hydrophilic components. To better understand its solubility characteristics, consider the following points:

  • Hydrophobic Nature: The benzo[a]heptalen core suggests a nonpolar character, which can lead to limited solubility in polar solvents like water.
  • Hydrophilic Functional Groups: The presence of multiple methoxy groups and the dihydroxybutanedioic acid component introduces polar functionalities, enhancing solubility in polar solvents.
  • Solvent Effects: Generally, increased polarity in the molecular structure tends to increase solubility in polar solvents; thus, this compound may display better solubility in solvents like ethanol or methanol compared to water.
  • Selective Solubility: It is likely to exhibit selective solubility depending upon the pH and nature of the solvent, with potential solubility variations due to ionization at different pH levels.

Overall, the solubility of this compound is a balance between its hydrophobic and hydrophilic regions, making it essential to consider solvent choice and environmental conditions when assessing its solubility behavior. As with many complex organic compounds, detailed experimental solubility data is invaluable for precise applications.

Interesting facts

Interesting Facts about (7S)-7-amino-1,2,3,10-tetramethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one and 2,3-dihydroxybutanedioic acid

This intriguing compound is a combination of two distinct molecular entities that can carry a wealth of interesting properties and applications. Here are some notable points that highlight their significance:

1. Structural Complexity

  • The compound features a multi-ring structure, typical of aromatic hydrocarbons, which suggests interesting electronic properties and potential reactivity.
  • With its unique 7-amino group and multiple methoxy substituents, the compound can exhibit remarkable interactions with biological receptors or enzymes.

2. Biological Applications

  • The amino substituent contributes to its potential as a pharmaceutical agent; amino-derivatives are often linked to various therapeutic effects.
  • 2,3-dihydroxybutanedioic acid, also known as tartaric acid, is noteworthy for its role in biological systems, particularly in the metabolism of carbohydrates.
  • Such compounds may also have applications in chiral syntheses and catalysis due to the presence of asymmetric carbon centers.

3. Impacts on Research

Researchers are continually fascinated by the versatility of compounds like this one. As noted in various studies, “The unique structural attributes allow for a wide range of biological activities and potential roles in drug design.” Thus, they are pivotal in advancing medicinal chemistry.

4. Synthesis Challenges

  • The synthesis of such complex molecules often presents challenges, requiring innovative methodologies and careful control over reaction conditions.
  • Methods may include multi-step organic reactions, where each step must be optimized for yield and purity, illustrating the profound skill involved in synthetic organic chemistry.

In summary, the exploration of (7S)-7-amino-1,2,3,10-tetramethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one and 2,3-dihydroxybutanedioic acid not only emphasizes the richness of organic chemistry but also their potential to impact diverse scientific fields from pharmaceutical sciences to materials development. The ongoing research into their properties and applications continues to inspire chemists around the world.

Synonyms
Colchicine, N-deacetyl-, tartrate
Trimethylcolchicinic acid methyl ether D-tartrate
RefChem:1082110
N-Deacetylcolchicine tartrate
NSC 36354
27963-65-1
COLCHICINE, N-DEACETYL-, d-TARTRATE
CHEMBL2062293
SCHEMBL29392275
DTXSID70950649
JLRWNBXMQCGSEJ-UQKRIMTDSA-N
2,3-Dihydroxybutanedioic acid--7-amino-1,2,3,10-tetramethoxy-6,7-dihydrobenzo[a]heptalen-9(5H)-one (1/1)