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Ingenol mebutate

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Identification
Molecular formula
C25H34O6
CAS number
75567-37-2
IUPAC name
[(7S)-7-hydroxy-5,6,7,8-tetrahydro-3H-pyrrolizin-1-yl]methyl 2-hydroxy-2-(1-hydroxyethyl)-3-methyl-butanoate
State
State

At room temperature, Ingenol mebutate is typically in a liquid form, as it is often formulated with solvents or carriers that allow its application in various dermatological treatments.

Melting point (Celsius)
110.50
Melting point (Kelvin)
383.65
Boiling point (Celsius)
362.30
Boiling point (Kelvin)
635.45
General information
Molecular weight
416.52g/mol
Molar mass
416.5170g/mol
Density
0.8697g/cm3
Appearence

The compound typically appears as a colorless to yellowish liquid. It is generally viscous and may have a characteristic odor depending on its purity and formulation.

Comment on solubility

Solubility of [(7S)-7-hydroxy-5,6,7,8-tetrahydro-3H-pyrrolizin-1-yl]methyl 2-hydroxy-2-(1-hydroxyethyl)-3-methyl-butanoate

When considering the solubility of the compound [(7S)-7-hydroxy-5,6,7,8-tetrahydro-3H-pyrrolizin-1-yl]methyl 2-hydroxy-2-(1-hydroxyethyl)-3-methyl-butanoate, several factors come into play:

  • Polarity: The presence of multiple hydroxyl groups suggests that this compound may be relatively polar, which could enhance its solubility in polar solvents such as water.
  • Hydrogen Bonding: The hydroxyl functional groups (–OH) can engage in hydrogen bonding, facilitating interactions with solvent molecules.
  • Molecular Structure: The complex structure may lead to variations in solubility based on the conformation and arrangement of functional groups.
  • Solvent Dependency: While the compound may show good solubility in polar solvents, it could be poorly soluble in non-polar solvents.

As a result of these factors, it is anticipated that the solubility of this compound will be moderate to high in polar solvents, with specific conditions varying based on the solvent system used. Experimentation might provide definitive insights into its solubility behavior.

Interesting facts

Interesting Facts about [(7S)-7-hydroxy-5,6,7,8-tetrahydro-3H-pyrrolizin-1-yl]methyl 2-hydroxy-2-(1-hydroxyethyl)-3-methyl-butanoate

This compound exhibits fascinating characteristics that make it an interesting subject in the field of chemistry and pharmacology. Here are some noteworthy facts:

  • Complex Structure: The compound features a multi-ring structure that includes pyrrolizine, which is a bicyclic compound. This complexity is not only intriguing for synthetic chemistry but also for understanding biological mechanisms.
  • Potential Biological Activity: Compounds with similar structures are often studied for their potential pharmacological applications, including antioxidant and anticancer properties. The presence of hydroxy groups may enhance their activity.
  • Stereochemistry: The specific stereochemistry indicated by (7S) suggests that this compound may exhibit specific interactions with biological targets, leading to unique pharmacokinetic profiles.
  • Synthesis Challenges: The synthesis of such complex molecules can be challenging and may require multiple steps and techniques. This highlights the advancements chemists have made in organic synthesis strategies.
  • Natural Sources: Compounds related to this structure are often found in nature, hinting at their evolutionary significance in various biological pathways.

As quoted by renowned chemist Linus Pauling, “The best way to have a good idea is to have lots of ideas.”
The structural intricacies and potential applications of [(7S)-7-hydroxy-5,6,7,8-tetrahydro-3H-pyrrolizin-1-yl]methyl 2-hydroxy-2-(1-hydroxyethyl)-3-methyl-butanoate exemplify the rich tapestry of creativity and innovation in the realms of both synthetic chemistry and natural product research.