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Everolimus

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Identification
Molecular formula
C53H83NO14
CAS number
159351-69-6
IUPAC name
[(7S,11S,12R,13S,14R,15R,16R,17S,18S)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[[(4-methylpiperazin-1-yl)amino]methylene]-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,24,27-octaen-13-yl] acetate
State
State
Everolimus is in a solid state at room temperature, usually appearing as a fine powder.
Melting point (Celsius)
179.50
Melting point (Kelvin)
452.70
Boiling point (Celsius)
276.50
Boiling point (Kelvin)
549.70
General information
Molecular weight
958.22g/mol
Molar mass
958.2240g/mol
Density
1.1500g/cm3
Appearence
Everolimus typically appears as a white to faintly yellow powder.
Comment on solubility

Solubility of the Compound

The solubility of the compound with the complex structure of [(7S,11S,12R,13S,14R,15R,16R,17S,18S)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[[(4-methylpiperazin-1-yl)amino]methylene]-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,24,27-octaen-13-yl] acetate can exhibit a range of behaviors depending on several factors.

  • Polarity: The presence of multiple hydroxyl (-OH) groups often enhances solubility in polar solvents such as water, while the methoxy and acetate groups may also contribute to its polarity.
  • Hydrophilicity vs. Hydrophobicity: Despite its polar -OH groups, the large hydrophobic hydrocarbon framework could hinder its overall solubility, especially in aqueous environments.
  • Interactions: The amino groups can form hydrogen bonds with solvents, potentially increasing solubility in certain organic solvents.

It is essential to note that the solubility may vary greatly under different conditions:

  • Temperature: Higher temperatures often increase solubility for many organic compounds.
  • pH Levels: The ionization of functional groups in different pH conditions can significantly influence solubility.
  • Presence of Other Solutes: Solubility can be affected by the presence of other compounds, which may stabilize or destabilize interactions.

Overall, while the complexity of this compound suggests challenges in understanding its solubility profile, careful examination of its molecular interactions with solvents can provide insightful conclusions.

Interesting facts

Interesting Facts about the Compound

This complex compound is a fascinating example of how intricate the world of chemistry can be. Known for its significant biological and pharmaceutical implications, it offers a rich tapestry of interactions and properties that are worthy of exploration.

Structural Complexity

One of the most striking features of this compound is its multi-layered structure, which incorporates numerous functional groups, including:

  • Hydroxyl groups - contributing to solubility and reactivity.
  • Methoxy group - enhancing its chemical stability and influencing biological activity.
  • Amide linkage - important for the compound's interaction with biological targets.

These functional groups facilitate a variety of reactions and interactions, making the compound a versatile candidate for drug design.

Biological Significance

This compound's unique configuration and functional groups allow it to interact specifically with various biological targets. Some of its potential applications include:

  • Antitumor agents - by targeting specific pathways linked to cancer cell proliferation.
  • Neuroactive compounds - with potential applications in treating neurological disorders.
  • Antimicrobial properties - fighting bacterial and fungal infections.

These features underscore the importance of exploring the structure-activity relationship (SAR) for derivatives of this compound.

Chemical Studies and Synthesis

Synthesizing such a compound is no small feat; the strategies often involve:

  • Multistep synthesis - each step must be carefully controlled and optimized.
  • Use of protecting groups - to ensure selective reactions occur without unwanted side products.
  • Advanced purification techniques - such as chromatography, to isolate the desired product efficiently.

The complexity of its synthesis reflects the innovative approaches chemists use to create compounds with significant therapeutic potential.

In conclusion, this compound illustrates the incredible potential of chemical compounds in addressing various health challenges. As chemistry continues to evolve, so too does our understanding and ability to manipulate such complex structures for beneficial purposes.